日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A qualitative exploration of the experiences of adults with cystic fibrosis unable to benefit from triple combination therapy

对无法从三联疗法中获益的囊性纤维化成年患者的经历进行定性探索

Mwelwa, Mulongwe; Hobson, Christopher; Stirk, Steven; Lewis, Heledd; Samuel, Victoria

The fast-evolving FIKK kinase family of Plasmodium falciparum can be inhibited by a single compound.

恶性疟原虫快速进化的 FIKK 激酶家族可被单一化合物抑制

Belda Hugo, Bradley David, Christodoulou Evangelos, Nofal Stephanie D, Broncel Malgorzata, Jones David, Davies Heledd, Bertran M Teresa, Purkiss Andrew G, Ogrodowicz Roksana W, Joshi Dhira, O'Reilly Nicola, Walport Louise, Powell Andrew, House David, Kjaer Svend, Claessens Antoine, Landry Christian R, Treeck Moritz

Synaptic changes contribute to persistent extra-motor behaviour deficits in amyotrophic lateral sclerosis.

突触变化是肌萎缩侧索硬化症患者持续存在运动外行为缺陷的原因之一。

Luan Wei, San Gil Rebecca, Madrid San Martin Lidia, Cao Maize C, Vassallu Florencia, Venturato Juliana, West Phillip K, Brown-Wright Heledd, Bademosi Adekunle T, Chye Yi Jia, Wu Hao Yu, Harutyunyan Anna, Robinson Katherine J, Chang Mu Sheen, Blizzard Catherine A, Scotter Emma L, Igaz Lionel M, Walker Adam K

Drug resistance-associated mutations in Plasmodium UBP-1 disrupt its essential deubiquitinating activity

疟原虫UBP-1中与耐药性相关的突变会破坏其必需的去泛素化活性。

Smith, Cameron J; Eavis, Heledd; Briggs, Carla; Henrici, Ryan; Karpiyevich, Maryia; Ansbro, Megan R; Hoshizaki, Johanna; van der Heden van Noort, Gerbrand J; Ascher, David B; Sutherland, Colin J; Lee, Marcus C S; Artavanis-Tsakonas, Katerina

FACS-based detection of extracellular ASC specks from NLRP3 inflammasomes in inflammatory diseases.

基于 FACS 检测炎症性疾病中 NLRP3 炎症小体的细胞外 ASC 斑点

Topping Joanne, Lara-Reyna Samuel, Ibbotson Alice, Jarosz-Griffiths Heledd, Chang Leon, Poulter James, Peckham Daniel, McDermott Michael F, Savic Sinisa

Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance.

恶性疟原虫体外系统进化揭示了耐药性的关键决定因素

Luth Madeline R, Godinez-Macias Karla P, Chen Daisy, Okombo John, Thathy Vandana, Cheng Xiu, Daggupati Sindhu, Davies Heledd, Dhingra Satish K, Economy Jan M, Edgar Rebecca C S, Gomez-Lorenzo Maria G, Istvan Eva S, Jado Juan Carlos, LaMonte Gregory M, Melillo Bruno, Mok Sachel, Narwal Sunil K, Ndiaye Tolla, Ottilie Sabine, Palomo Diaz Sara, Park Heekuk, Peña Stella, Rocamora Frances, Sakata-Kato Tomoyo, Small-Saunders Jennifer L, Summers Robert L, Tumwebaze Patrick K, Vanaerschot Manu, Xia Guoqin, Yeo Tomas, You Ashley, Gamo Francisco-Javier, Goldberg Daniel E, Lee Marcus C S, McNamara Case W, Ndiaye Daouda, Rosenthal Philip J, Schreiber Stuart L, Serra Gloria, De Siqueira-Neto Jair Lage, Skinner-Adams Tina S, Uhlemann Anne-Catrin, Kato Nobutaka, Lukens Amanda K, Wirth Dyann F, Fidock David A, Winzeler Elizabeth A

A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration

瞬时蛋白质折叠反应靶向 TDP-43 介导的神经退行性疾病早期阶段的聚集

Rebecca San Gil, Dana Pascovici, Juliana Venturato, Heledd Brown-Wright, Prachi Mehta, Lidia Madrid San Martin, Jemma Wu, Wei Luan, Yi Kit Chui, Adekunle T Bademosi, Shilpa Swaminathan, Serey Naidoo, Britt A Berning, Amanda L Wright, Sean S Keating, Maurice A Curtis, Richard L M Faull, John D Lee, S

PfHDAC1 is an essential regulator of P. falciparum asexual proliferation and host cell invasion genes with a dynamic genomic occupancy responsive to artemisinin stress

PfHDAC1 是恶性疟原虫无性增殖和宿主细胞侵袭基因的重要调节因子,具有对青蒿素应激作出反应的动态基因组占有率

Abhishek Kanyal, Bhagyashree Deshmukh, Heledd Davies, D V Mamatharani, Dilsha Farheen, Moritz Treeck, Krishanpal Karmodiya

Prognostic factors of poor outcomes in pneumonia in older adults: aspiration or frailty?

老年人肺炎预后不良的预后因素:吸入性肺炎还是体弱?

Yoshimatsu, Yuki; Thomas, Heledd; Thompson, Trevor; Smithard, David G

Virtual consultations: the experience of oncology and palliative care healthcare professionals

虚拟会诊:肿瘤科和姑息治疗医护人员的经验

Lewis, Heledd; Taubert, Mark; Nelson, Annmarie