日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Anti-inflammatory effects of elexacaftor/tezacaftor/ivacaftor in adults with cystic fibrosis heterozygous for F508del

elexacaftor/tezacaftor/ivacaftor 对 F508del 杂合子囊性纤维化成人患者的抗炎作用

Jarosz-Griffiths, Heledd H; Gillgrass, Lindsey; Caley, Laura R; Spoletini, Giulia; Clifton, Ian J; Etherington, Christine; Savic, Sinisa; McDermott, Michael F; Peckham, Daniel

Neurodegenerative Disease and the NLRP3 Inflammasome

神经退行性疾病与NLRP3炎症小体

Holbrook, Jonathan A; Jarosz-Griffiths, Heledd H; Caseley, Emily; Lara-Reyna, Samuel; Poulter, James A; Williams-Gray, Caroline H; Peckham, Daniel; McDermott, Michael F

Different CFTR modulator combinations downregulate inflammation differently in cystic fibrosis

不同的 CFTR 调节剂组合对囊性纤维化炎症的下调作用不同

Heledd H Jarosz-Griffiths #, Thomas Scambler #, Chi H Wong, Samuel Lara-Reyna, Jonathan Holbrook, Fabio Martinon, Sinisa Savic, Paul Whitaker, Christine Etherington, Giulia Spoletini, Ian Clifton, Anil Mehta, Michael F McDermott, Daniel Peckham

ENaC-mediated sodium influx exacerbates NLRP3-dependent inflammation in cystic fibrosis

ENaC介导的钠离子内流加剧囊性纤维化中的NLRP3依赖性炎症

Thomas Scambler # ,Heledd H Jarosz-Griffiths # ,Samuel Lara-Reyna ,Shelly Pathak ,Chi Wong ,Jonathan Holbrook ,Fabio Martinon ,Sinisa Savic ,Daniel Peckham # ,Michael F McDermott #

Metabolic Reprograming of Cystic Fibrosis Macrophages via the IRE1α Arm of the Unfolded Protein Response Results in Exacerbated Inflammation

囊性纤维化巨噬细胞通过未折叠蛋白反应的IRE1α通路进行代谢重编程,导致炎症加剧

Samuel Lara-Reyna ,Thomas Scambler ,Jonathan Holbrook ,Chi Wong ,Heledd H Jarosz-Griffiths ,Fabio Martinon ,Sinisa Savic ,Daniel Peckham ,Michael F McDermott

Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-β oligomers

通过激活金属肽酶 ADAM10 水解脱落朊病毒蛋白,可降低淀粉样β寡聚体的细胞结合力和毒性

Heledd H Jarosz-Griffiths, Nicola J Corbett, Helen A Rowland, Kate Fisher, Alys C Jones, Jennifer Baron, Gareth J Howell, Sally A Cowley, Satyan Chintawar, M Zameel Cader, Katherine A B Kellett, Nigel M Hooper

Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil

淀粉样蛋白 β 突触毒性依赖于 Wnt-PCP,可被法舒地尔阻断

Katherine J Sellers, Christina Elliott, Joshua Jackson, Anshua Ghosh, Elena Ribe, Ana I Rojo, Heledd H Jarosz-Griffiths, Iain A Watson, Weiming Xia, Mikhail Semenov, Peter Morin, Nigel M Hooper, Rod Porter, Jane Preston, Raya Al-Shawi, George Baillie, Simon Lovestone, Antonio Cuadrado, Michael Harte

Amyloid-β Receptors: The Good, the Bad, and the Prion Protein

β-淀粉样蛋白受体:好、坏与朊病毒蛋白

Jarosz-Griffiths, Heledd H; Noble, Elizabeth; Rushworth, Jo V; Hooper, Nigel M

Lipid rafts: linking prion protein to zinc transport and amyloid-β toxicity in Alzheimer's disease

脂筏:将朊病毒蛋白与阿尔茨海默病中的锌转运和β-淀粉样蛋白毒性联系起来

Watt, Nicole T; Griffiths, Heledd H; Hooper, Nigel M

Prion protein-mediated toxicity of amyloid-β oligomers requires lipid rafts and the transmembrane LRP1

朊病毒蛋白介导的β-淀粉样蛋白寡聚体的毒性需要脂筏和跨膜LRP1。

Rushworth, Jo V; Griffiths, Heledd H; Watt, Nicole T; Hooper, Nigel M