日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

KRAS4a and KRAS4b show distinct lipid-dependent regulation of RAS-RAF membrane dynamics

KRAS4a 和 KRAS4b 对 RAS-RAF 膜动力学表现出不同的脂质依赖性调控作用

Georgouli, Konstantia; Tempkin, Jeremy O B; Stanton, Liam G; Oppelstrup, Tomas; Shrestha, Rebika; Carpenter, Timothy S; Aydin, Fikret; Zhang, Xiaohua; Bhatia, Harsh; Yang, Yue; Van, Que N; Bonilla, Pedro Andrade; Gulten, Gulcin; Goswami, Debanjan; Di Natale, Francesco; Chavez, Joseph R; Moon, Joseph Y; Dharuman, Gautham; Hengartner, Nicolas W; Simanshu, Dhirendra K; Tran, Timothy H; Nguyen, Kien; Stanley, Christopher B; Van Essen, Brian; Bremer, Peer-Timo; Lightstone, Felice C; Stephen, Andrew G; Glosli, James N; Gnanakaran, Sandrasegaram; Turbyville, Thomas J; McCormick, Frank; Nissley, Dwight V; Streitz, Frederick H; Ingólfsson, Helgi I

Dynamics and lipid membrane coupling of the RAS-RAF complex revealed via multiscale simulations

通过多尺度模拟揭示RAS-RAF复合物的动力学和脂质膜耦合

Carpenter, Timothy S; Aydin, Fikret; Neale, Chris; Van, Que N; Zhang, Xiaohua; Bhatia, Harsh; Sidabras, Jason W; Frank, Peter H; Georgouli, Konstantia; Tempkin, Jeremy O B; Casamayor, Violeta Burns; Gulten, Gulcin; Shrestha, Rebika; Goswami, Debanjan; Di Natale, Francesco; Chavez, Joseph R; Moody, Adam; Moon, Joseph Y; Oppelstrup, Tomas; Glosli, James N; Dharuman, Gautham; Wong, Sergio; Liu, Shusen; Hengartner, Nicolas W; López, Cesar A; Nguyen, Kien; Stanley, Christopher B; Stanton, Liam G; Patel, Lara; Reddy, Tyler; Turbyville, Thomas J; Van Essen, Brian; Bremer, Peer-Timo; Lightstone, Felice C; Stephen, Andrew G; Gnanakaran, Sandrasegaram; McCormick, Frank; Nissley, Dwight V; Streitz, Frederick H; Ingólfsson, Helgi I

The Martini 3 Lipidome: Expanded and Refined Parameters Improve Lipid Phase Behavior

Martini 3 脂质组:扩展和改进的参数改善了脂质相行为

Pedersen, Kasper B; Ingólfsson, Helgi I; Ramirez-Echemendia, Daniel P; Borges-Araújo, Luís; Andreasen, Mikkel D; Empereur-Mot, Charly; Melcr, Josef; Ozturk, Tugba N; Bennett, W F Drew; Kjølbye, Lisbeth R; Brasnett, Christopher; Corradi, Valentina; Khan, Hanif M; Cino, Elio A; Crowley, Jackson; Kim, Hyuntae; Fábián, Balázs; Borges-Araújo, Ana C; Pavan, Giovanni M; Launay, Guillaume; Lolicato, Fabio; Wassenaar, Tsjerk A; Melo, Manuel N; Thallmair, Sebastian; Carpenter, Timothy S; Monticelli, Luca; Tieleman, D Peter; Schiøtt, Birgit; Souza, Paulo C T; Marrink, Siewert J

An in vitro BRAF activation assay elucidates molecular mechanisms driving disassembly of the autoinhibited BRAF state

体外BRAF激活实验阐明了驱动BRAF自身抑制状态解体的分子机制

Ritt, Daniel A; Durrant, David E; Drew, Matthew R; Sandin, Suzanne I; Martinez Fiesco, Juliana A; Zhang, Xiaohua; Aydin, Fikret; Carpenter, Timothy S; Scheidemantle, Grace M; D'Ippolito, Robert A; Sohn, Alexandria L; DeHart, Caroline J; Shrestha, Rebika; Snead, Kelly; Hull, Jenna; Tempkin, Jeremy O B; Yang, Yue; Lightstone, Felice C; Streitz, Frederick H; Zhang, Ping; Turbyville, Thomas J; Stephen, Andrew G; Esposito, Dominic; Ingólfsson, Helgi I; Nissley, Dwight V; Morrison, Deborah K

Integrating Ultra-Coarse-Grained Protein Models into Accessible Workflows for Multiscale Molecular Dynamics

将超粗粒化蛋白质模型集成到易于使用的多尺度分子动力学工作流程中

Chi, Bryce Tu; Fulcar, Stephanie; Ipe, Jonathan; Schleifer, Olivia; Subramanian, Rohan; Vlases, Claire; Matasci, Naim; Georgouli, Konstantia; Pottier, Loïc; Hsu, Tim; Carpenter, Timothy S; Nissley, Dwight V; Lightstone, Felice C; Streitz, Frederick H; Ingólfsson, Helgi I; Aydin, Fikret

Highly tail-asymmetric lipids interdigitate and cause bidirectional ordering

尾部高度不对称的脂质相互交错,导致双向有序排列。

Ozturk, Tugba N; Ferron, Thomas J; He, Wei; Schwarz, Benjamin; Weiss, Thomas M; Fischer, Nicholas O; Rasley, Amy; Carpenter, Timothy S; Bosio, Catharine M; Ingólfsson, Helgi I

Enhanced Exploration of Protein Conformational Space through Integration of Ultra-Coarse-Grained Models to Multiscale Workflows

通过将超粗粒化模型集成到多尺度工作流程中,增强对蛋白质构象空间的探索

Aydin, Fikret; Georgouli, Konstantia; Pottier, Loïc; Oppelstrup, Tomas; Carpenter, Timothy S; Tempkin, Jeremy O B; Bremer, Peer-Timo; Nissley, Dwight V; Streitz, Frederick H; Lightstone, Felice C; Ingólfsson, Helgi I

Free energy and flexibility analysis of autoinhibited human BRAF

对自身抑制的人类BRAF进行自由能和柔性分析

Tempkin, Jeremy O B; Aydin, Fikret; Essiz, Sebnem; Yang, Yue; Carpenter, Timothy S; Durrant, David E; Morrison, Deborah K; Ingólfsson, Helgi I; Streitz, Frederick H; Nissely, Dwight V; Lightstone, Felice C; Zhang, Xiaohua

Generating Protein Structures for Pathway Discovery Using Deep Learning

利用深度学习生成蛋白质结构以进行通路发现

Georgouli, Konstantia; Stephany, Robert R; Tempkin, Jeremy O B; Santiago, Claudio; Aydin, Fikret; Heimann, Mark A; Pottier, Loïc; Zhang, Xiaohua; Carpenter, Timothy S; Hsu, Tim; Nissley, Dwight V; Streitz, Frederick H; Lightstone, Felice C; Ingolfsson, Helgi I; Bremer, Peer-Timo

Author Correction: Membrane lipids drive formation of KRAS4b-RAF1 RBDCRD nanoclusters on the membrane

作者更正:膜脂驱动膜上KRAS4b-RAF1 RBDCRD纳米簇的形成

Shrestha, Rebika; Carpenter, Timothy S; Van, Que N; Agamasu, Constance; Tonelli, Marco; Aydin, Fikret; Chen, De; Gulten, Gulcin; Glosli, James N; López, Cesar A; Oppelstrup, Tomas; Neale, Chris; Gnanakaran, Sandrasegaram; Gillette, William K; Ingólfsson, Helgi I; Lightstone, Felice C; Stephen, Andrew G; Streitz, Frederick H; Nissley, Dwight V; Turbyville, Thomas J