日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

TGF-α/EGFR-mediated lymphatic metastasis reveals a repositionable therapeutic target in breast cancer.

TGF-α/EGFR介导的淋巴转移揭示了乳腺癌中一个可重新定位的治疗靶点。

Shi Wenyang, Pan Yueyun, Rathod Bhavik, Wang Yuhan, Wang Zhi, Shen Jianyu, Gatto Francesca, Liu Mingzhi, Sun Yizhe, Wilhelm Margareta, Helleday Thomas, Ulvmar Maria H, Windahl Sara H, Karlsson Mikael C I, Fuxe Jonas

A monofunctional-like mutant of DNA glycosylase NTHL1 changes the dynamics of DNA repair during acute oxidative stress

DNA糖基化酶NTHL1的单功能样突变体改变了急性氧化应激期间DNA修复的动态过程。

Haslam, James; Rudolfova, Natalie; Zhou, Kaixin; Homan, Evert; Jemth, Ann-Sofie; Michel, Maurice; Helleday, Thomas; Mortusewicz, Oliver

Nucleobase catalysts for the enzymatic activation of 8-oxoguanine DNA glycosylase 1

核碱基催化剂用于8-氧鸟嘌呤DNA糖基化酶1的酶促活化

Hank, Emily C; D'Arcy-Evans, Nicholas D; Scaletti, Emma Rose; Benítez-Buelga, Carlos; Wallner, Olov; Ortis, Florian; Zhou, Kaixin; Meng, Liuzhen; Del Prado, Alicia; Calvo, Patricia; Almlöf, Ingrid; Wiita, Elisée; Nierlin, Karen; Košenina, Sara; Krämer, Andreas; Eddershaw, Alice; Kehler, Mario; Long, Maeve; Jemth, Ann-Sofie; Dawson, Holly; Stewart, Josephine; Dickey, Adam; Astorga, Mikhael E; Varga, Marek; Homan, Evert J; Scobie, Martin; Knapp, Stefan; Sastre, Leandro; Stenmark, Pål; de Vega, Miguel; Helleday, Thomas; Michel, Maurice

Virtual fragment screening for DNA repair inhibitors in vast chemical space.

在广阔的化学空间中对DNA修复抑制剂进行虚拟片段筛选

Luttens Andreas, Vo Duc Duy, Scaletti Emma R, Wiita Elisée, Almlöf Ingrid, Wallner Olov, Davies Jonathan, Košenina Sara, Meng Liuzhen, Long Maeve, Mortusewicz Oliver, Masuyer Geoffrey, Ballante Flavio, Michel Maurice, Homan Evert, Scobie Martin, Kalderén Christina, Warpman Berglund Ulrika, Tarnovskiy Andrii V, Radchenko Dmytro S, Moroz Yurii S, Kihlberg Jan, Stenmark Pål, Helleday Thomas, Carlsson Jens

Mitotic MTH1 inhibitor karonudib kills epithelial ovarian cancer independent of platinum sensitivity

有丝分裂抑制剂MTH1 karonudib 可杀死上皮性卵巢癌细胞,且该作用与铂类药物敏感性无关。

Hurley, Rachel M; Wagner, Jill M; Kanakkanthara, Arun; Venkatachalam, Annapoorna; Deisinger, Aaron M; Correia, Cristina; Schneider, Paula A; Peterson, Kevin L; Macon, Elaine P; Heinzen, Ethan P; Sanjiv, Kumar; Hou, Xiaonan; Becker, Marc A; Maurer, Matthew J; Larson, Melissa C; Swisher, Elizabeth M; Li, Hu; Oberg, Ann L; Weroha, S John; Berglund, Ulrika Warpman; Helleday, Thomas; Kaufmann, Scott H; Hendrickson, Andrea E Wahner

Giving an Enzyme Scissors: Serotonin Derivatives as Potent Organocatalytic Switches for DNA Repair Enzyme OGG1

赋予酶剪刀:血清素衍生物作为DNA修复酶OGG1的强效有机催化开关

Varga, Marek; Ortis, Florian; Del Prado, Alicia; Eddershaw, Alice; Scaletti Hutchinson, Emma; Hank, Emily C; Zhou, Kaixin; Rudolfová, Natálie; Dodaro, Alessia; Wiita, Elisée; Almlöf, Ingrid; Karsten, Stella; Mamonov, Kirill; Ahmed, Sara H; Bentley, Kirsty; Wallner, Olov; Homan, Evert J; Scobie, Martin; Helleday, Thomas; Prejanò, Mario; Stenmark, Pål; de Vega, Miguel; Watson, Allan J B; Michel, Maurice

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

合成代谢类固醇司坦唑醇是人类 MutT 同源物 1 的强效抑制剂。

Scaletti Hutchinson, Emma; Gustafsson Westergren, Robert; Almlöf, Ingrid; Jemth, Ann-Sofie; Scobie, Martin; Warpman Berglund, Ulrika; Helleday, Thomas; Stenmark, Pål

Targeting OGG1 and PARG radiosensitises head and neck cancer cells to high-LET protons through complex DNA damage persistence

靶向 OGG1 和 PARG 放射可通过复杂的 DNA 损伤持久性使头颈癌细胞对高 LET 质子敏感

Maria Rita Fabbrizi, Catherine M Nickson, Jonathan R Hughes, Emily A Robinson, Karthik Vaidya, Carlos P Rubbi, Andrzej Kacperek, Helen E Bryant, Thomas Helleday, Jason L Parsons

Mitotic MTH1 inhibitor TH1579 induces PD-L1 expression and inflammatory response through the cGAS-STING pathway

有丝分裂 MTH1 抑制剂 TH1579 通过 cGAS-STING 通路诱导 PD-L1 表达和炎症反应

Jianyu Shen, Emilio Guillén Mancina, Shenyu Chen, Theodora Manolakou, Helge Gad, Ulrika Warpman Berglund, Kumar Sanjiv, Thomas Helleday

The one-carbon metabolic enzyme MTHFD2 promotes resection and homologous recombination after ionizing radiation

一碳代谢酶MTHFD2促进电离辐射后的切除和同源重组

Petra Marttila, Nadilly Bonagas, Christina Chalkiadaki, Hannah Stigsdotter, Korbinian Schelzig, Jianyu Shen, Crystal M Farhat, Amber Hondema, Julian Albers, Elisée Wiita, Azita Rasti, Ulrika Warpman Berglund, Ana Slipicevic, Oliver Mortusewicz, Thomas Helleday