The serine protease HTRA1 targets tau fibrils and provides a proteolytic barrier against pathogenic protein conformations
丝氨酸蛋白酶HTRA1靶向tau蛋白原纤维,并提供一道蛋白水解屏障,抵御致病性蛋白构象的形成。
期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1016/j.jbc.2025.110729
Hagemeier, Birte; Ripkens, Kamilla; Schulze, Nina; Bluemke, Anika; Strzala, Michal; Koci, Michelle; Kaschani, Farnusch; Kaiser, Markus; Erkelenz, Michael; Schluecker, Sebastian; Merdanovic, Melisa; Poepsel, Simon; Hellerschmied, Doris; Burston, Steven G; Ehrmann, Michael