日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Expanding the payload scope in antibody-drug conjugates by delivery of hydroxy-containing drugs through self-immolative phosphoramidates

通过自裂解磷酰胺递送含羟基药物，扩大抗体药物偶联物的有效载荷范围

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-026-68605-y
Ochtrop, Philipp; Jagtap, Anil P; Felber, Jan G; Vogt, Simon; Herterich, Sarah; Mai, Isabelle; Cyprys, Philipp; Schmitt, Saskia; Payer, Sarah; Kitowski, Annabel; Wunder, Swetlana; Machui, Paul; Brandmeier, Julia; Leonardi, Natascia; Poliak, Elizaveta; Hackenberger, Christian P R; Marcq, Olivier; Schumacher, Dominik; Helma, Jonas; Vogl, Annette M; Kasper, Marc-André
发表日期：2026
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Orthogonal Site-Specific Dual Bioconjugation of Aryl and Alkyl Thiols

芳基硫醇和烷基硫醇的正交位点特异性双重生物偶联

期刊:Journal of the American Chemical Society
影响因子:15.6
doi:10.1021/jacs.5c02981
de Geus, Mark A R; Stieger, Christian E; Arafiles, Jan Vincent V; Lotthé, Jean-Romain P J; Schmieder, Peter; Kemnitz-Hassanin, Kristin; Kindt, Beate; Leonhardt, Heinrich; Schmitt, Saskia; Gerlach, Marcus; Schumacher, Dominik; Helma, Jonas; Kasper, Marc-André; Hackenberger, Christian P R
发表日期：2025
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Effective eradication of acute myeloid leukemia stem cells with FLT3-directed antibody-drug conjugates

利用FLT3靶向抗体药物偶联物有效根除急性髓系白血病干细胞

期刊:Leukemia
影响因子:13.4
doi:10.1038/s41375-024-02510-5
Able, Marina; Kasper, Marc-André; Vick, Binje; Schwach, Jonathan; Gao, Xiang; Schmitt, Saskia; Tizazu, Belay; Fischer, Amrei; Künzl, Sarah; Leilich, Marit; Mai, Isabelle; Ochtrop, Philipp; Stengl, Andreas; de Geus, Mark A R; von Bergwelt-Baildon, Michael; Schumacher, Dominik; Helma, Jonas; Hackenberger, Christian P R; Götze, Katharina S; Jeremias, Irmela; Leonhardt, Heinrich; Feuring, Michaela; Spiekermann, Karsten
发育与干细胞
FLT3
白血病
干细胞
细胞生物学
发表日期：2025
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TUB-040, a Homogeneous and Hydrophilic NaPi2b-Targeting ADC with Stably Linked Exatecan, Exhibits Long-lasting Antitumor Activity and a Well-Tolerated Safety Profile.

TUB-040 是一种均质亲水性 NaPi2b 靶向 ADC，其稳定连接了依沙替康，具有持久的抗肿瘤活性和良好的耐受性安全性。

期刊:Molecular Cancer Therapeutics
影响因子:5.5
doi:10.1158/1535-7163.MCT-25-0254
Vogl Annette M, Schmitt Saskia, Mai Isabelle, Machui Paul, Herterich Sarah, Leonardi Natascia, Cyprys Philipp, Hauswald Danila, Ochtrop Philipp, Kozlowska Izabela, Kitowski Annabel, Gerlach Marcus, Waldmann Florian, Marcq Olivier, Trail Pamela A, Schumacher Dominik, Fingerle-Rowson Günter R, Hock Björn, Kasper Marc-André, Helma Jonas
肿瘤
发表日期：2025
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Design and Evaluation of Phosphonamidate-Linked Exatecan Constructs for Highly Loaded, Stable, and Efficacious Antibody-Drug Conjugates

膦酰胺连接的依沙替康构建体的设计与评价及其在高载药量、稳定性和高效抗体-药物偶联物中的应用

期刊:Molecular Cancer Therapeutics
影响因子:5.5
doi:10.1158/1535-7163.MCT-23-0359
Schmitt, Saskia; Machui, Paul; Mai, Isabelle; Herterich, Sarah; Wunder, Swetlana; Cyprys, Philipp; Gerlach, Marcus; Ochtrop, Philipp; Hackenberger, Christian P R; Schumacher, Dominik; Helma, Jonas; Vogl, Annette M; Kasper, Marc-André
发表日期：2024
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Compact hydrophilic electrophiles enable highly efficacious high DAR ADCs with excellent in vivo PK profile

结构紧凑的亲水性亲电试剂能够制备高效、高药物抗体比（DAR）且具有优异体内药代动力学特征的抗体药物偶联物（ADC）。

期刊:Chemical Science
影响因子:7.4
doi:10.1039/d2sc05678j
Ochtrop, Philipp; Jahzerah, Jahaziel; Machui, Paul; Mai, Isabelle; Schumacher, Dominik; Helma, Jonas; Kasper, Marc-André; Hackenberger, Christian P R
发表日期：2023
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Site-Specific Antibody Fragment Conjugates for Reversible Staining in Fluorescence Microscopy

用于荧光显微镜可逆染色的位点特异性抗体片段偶联物

期刊:Chembiochem
影响因子:2.8
doi:10.1002/cbic.202000727
Schwach, Jonathan; Kolobynina, Ksenia; Brandstetter, Katharina; Gerlach, Marcus; Ochtrop, Philipp; Helma, Jonas; Hackenberger, Christian P R; Harz, Hartmann; Cardoso, M Cristina; Leonhardt, Heinrich; Stengl, Andreas
IF
发表日期：2021
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N-Hydroxysuccinimide-Modified Ethynylphosphonamidates Enable the Synthesis of Configurationally Defined Protein Conjugates

N-羟基琥珀酰亚胺修饰的乙炔基膦酰胺酯能够合成构型明确的蛋白质缀合物

期刊:Chembiochem
影响因子:2.8
doi:10.1002/cbic.201900587
Kasper, Marc-André; Gerlach, Marcus; Schneider, Anselm F L; Groneberg, Christiane; Ochtrop, Philipp; Boldt, Stefanie; Schumacher, Dominik; Helma, Jonas; Leonhardt, Heinrich; Christmann, Mathias; Hackenberger, Christian P R
发表日期：2020
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Ethynylphosphonamidates for the Rapid and Cysteine-Selective Generation of Efficacious Antibody-Drug Conjugates

乙炔基膦酰胺用于快速、半胱氨酸选择性地生成高效抗体-药物偶联物

期刊:Angewandte Chemie-International Edition
影响因子:16.9
doi:10.1002/anie.201904193
Kasper, Marc-André; Stengl, Andreas; Ochtrop, Philipp; Gerlach, Marcus; Stoschek, Tina; Schumacher, Dominik; Helma, Jonas; Penkert, Martin; Krause, Eberhard; Leonhardt, Heinrich; Hackenberger, Christian P R
发表日期：2019
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Nanobodies: Chemical Functionalization Strategies and Intracellular Applications

纳米抗体：化学功能化策略和细胞内应用

期刊:Angewandte Chemie-International Edition
影响因子:16.9
doi:10.1002/anie.201708459
Schumacher, Dominik; Helma, Jonas; Schneider, Anselm F L; Leonhardt, Heinrich; Hackenberger, Christian P R
细胞生物学
发表日期：2018
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