日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A subcutaneous cellular implant for passive immunization against amyloid-β reduces brain amyloid and tau pathologies

用于对抗淀粉样β蛋白的被动免疫的皮下细胞植入物可减少脑淀粉样蛋白和tau病理

Aurélien Lathuilière, Vanessa Laversenne, Alberto Astolfo, Erhard Kopetzki, Helmut Jacobsen, Marco Stampanoni, Bernd Bohrmann, Bernard L Schneider, Patrick Aebischer

Cargo Delivery into the Brain by in vivo identified Transport Peptides

通过体内识别的运输肽将货物运送到大脑

Eduard Urich, Roland Schmucki, Nadine Ruderisch, Eric Kitas, Ulrich Certa, Helmut Jacobsen, Christophe Schweitzer, Alessandra Bergadano, Martin Ebeling, Hansruedi Loetscher, Per-Ola Freskgård

Preclinical profile of a potent gamma-secretase inhibitor targeting notch signaling with in vivo efficacy and pharmacodynamic properties

针对 Notch 信号的强效 γ-分泌酶抑制剂的临床前概况,具有体内功效和药效学特性

Leopoldo Luistro, Wei He, Melissa Smith, Kathryn Packman, Maria Vilenchik, Daisy Carvajal, John Roberts, James Cai, Windy Berkofsky-Fessler, Holly Hilton, Michael Linn, Alexander Flohr, Roland Jakob-Røtne, Helmut Jacobsen, Kelli Glenn, David Heimbrook, John F Boylan

Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation

Abeta38 和 Abeta42 的生成受到家族性阿尔茨海默病相关早老素突变和 γ-分泌酶调节的独立且不同的影响

Richard M Page, Karlheinz Baumann, Masanori Tomioka, Blanca I Pérez-Revuelta, Akio Fukumori, Helmut Jacobsen, Alexander Flohr, Thomas Luebbers, Laurence Ozmen, Harald Steiner, Christian Haass