日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mutant induced neurons and humanized mice enable identification of Niemann-Pick type C1 proteostatic therapies

突变诱导的神经元和人源化小鼠能够识别尼曼匹克 C1 型蛋白质抑制剂疗法

Ruth D Azaria, Adele B Correia, Kylie J Schache, Manuela Zapata, Koralege C Pathmasiri, Varshasnata Mohanty, Dharma T Nannapaneni, Brandon L Ashfeld, Paul Helquist, Olaf Wiest, Kenji Ohgane, Qingqing Li, Ross A Fredenburg, Brian Sj Blagg, Stephanie M Cologna, Mark L Schultz, Andrew P Lieberman

Synthesis of Caged HMG-CoA Reductase Substrates for the Elucidation of Cellular Pathways

合成笼状HMG-CoA还原酶底物以阐明细胞通路

O'Connell, Ryan J; Dolphin, Nicholas J; Ferraudi, Guillermo; Lee, Mijoon; Stauffacher, Cynthia V; Helquist, Paul; Wiest, Olaf

pH-dependent reaction triggering in PmHMGR crystals for time-resolved crystallography

利用pH依赖性反应触发PmHMGR晶体进行时间分辨晶体学研究

Purohit, Vatsal; Steussy, Calvin N; Rosales, Anthony R; Critchelow, Chandra J; Schmidt, Tim; Helquist, Paul; Wiest, Olaf; Mesecar, Andrew; Cohen, Aina E; Stauffacher, Cynthia V

Computational Study of Base-Catalyzed Thiohemiacetal Decomposition in Pseudomonas mevalonii HMG-CoA Reductase

假单胞菌HMG-CoA还原酶中碱催化硫代半缩醛分解的计算研究

Patel, Himani N; Haines, Brandon E; Stauffacher, Cynthia V; Helquist, Paul; Wiest, Olaf

Automated fitting of transition state force fields for biomolecular simulations

生物分子模拟中过渡态力场的自动拟合

Quinn, Taylor R; Patel, Himani N; Koh, Kevin H; Haines, Brandon E; Norrby, Per-Ola; Helquist, Paul; Wiest, Olaf

Biocompatible, Multi-Mode, Fluorescent, T2 MRI Contrast Magnetoelectric-Silica Nanoparticles (MagSiNs), for On-Demand Doxorubicin Delivery to Metastatic Cancer Cells

生物相容性、多模式、荧光、T2 MRI 对比磁电二氧化硅纳米粒子 (MagSiNs),用于按需向转移性癌细胞输送阿霉素

Margo Waters, Juliane Hopf, Emma Tam, Stephanie Wallace, Jordan Chang, Zach Bennett, Hadrian Aquino, Ryan K Roeder, Paul Helquist, M Sharon Stack, Prakash D Nallathamby

Microsecond timescale MD simulations at the transition state of PmHMGR predict remote allosteric residues

在PmHMGR过渡态下进行的微秒级分子动力学模拟预测了远端变构残基

Quinn, Taylor R; Steussy, Calvin N; Haines, Brandon E; Lei, Jinping; Wang, Wei; Sheong, Fu Kit; Stauffacher, Cynthia V; Huang, Xuhui; Norrby, Per-Ola; Helquist, Paul; Wiest, Olaf

HSP90 inhibitors reduce cholesterol storage in Niemann-Pick type C1 mutant fibroblasts

HSP90 抑制剂可减少尼曼匹克 C1 型突变成纤维细胞中的胆固醇储存

Nina H Pipalia, Syed Z Saad, Kanagaraj Subramanian, Abigail Cross, Aisha Al-Motawa, Kunal Garg, Brian S J Blagg, Len Neckers, Paul Helquist, Olaf Wiest, Daniel S Ory, Frederick R Maxfield

Inhibition of Histone Deacetylases 1, 2, and 3 Enhances Clearance of Cholesterol Accumulation in Niemann-Pick C1 Fibroblasts

抑制组蛋白去乙酰化酶 1、2 和 3 可增强尼曼-匹克 C1 成纤维细胞中胆固醇积累的清除

Dana L Cruz, Nina Pipalia, Shu Mao, Deepti Gadi, Gang Liu, Michael Grigalunas, Matthew O'Neill, Taylor R Quinn, Andi Kipper, Andreas Ekebergh, Alexander Dimmling, Carlos Gartner, Bruce J Melancon, Florence F Wagner, Edward Holson, Paul Helquist, Olaf Wiest, Frederick R Maxfield

Stereoselectivity Predictions for the Pd-Catalyzed 1,4-Conjugate Addition Using Quantum-Guided Molecular Mechanics

利用量子力学方法预测钯催化1,4-共轭加成反应的立体选择性

Wahlers, Jessica; Maloney, Michael; Salahi, Farbod; Rosales, Anthony R; Helquist, Paul; Norrby, Per-Ola; Wiest, Olaf