日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

GABAergic interneurons contribute to the fatal seizure phenotype of CLN2 disease mice

GABA能中间神经元与CLN2疾病小鼠的致命性癫痫表型有关。

Takahashi, Keigo; Rensing, Nicholas R; Eultgen, Elizabeth M; Williams, Letitia L; Wang, Sophie H; Nelvagal, Hemanth R; Le, Steven Q; Roberts, Marie S; Doray, Balraj; Han, Edward B; Dickson, Patricia I; Wong, Michael; Sands, Mark S; Cooper, Jonathan D

Limited therapeutic efficacy of N-acetyl-L-leucine in a mouse model of CLN1 disease

N-乙酰-L-亮氨酸在CLN1疾病小鼠模型中的治疗效果有限

Ziółkowska, Ewa A; Pagán Torres, Nicole A; Chen, Hsintsung; Williams, Letitia L; Eultgen, Elizabeth M; Nowacka, Agnieszka; Dearborn, Joshua T; Nelvagal, Hemanth R; Whiteman, Ineka T; Platt, Frances M; Cooper, Jonathan D

Neuronal deletion of the circadian clock gene Bmal1 induces cell-autonomous dopaminergic neurodegeneration

神经元缺失昼夜节律基因 Bmal1 可诱发细胞自主性多巴胺能神经变性

Michael F Kanan, Patrick W Sheehan, Jessica N Haines, Pedro G Gomez, Adya Dhuler, Collin J Nadarajah, Zachary M Wargel, Brittany M Freeberg, Hemanth R Nelvagal, Mariko Izumo, Joseph S Takahashi, Jonathan D Cooper, Albert A Davis, Erik S Musiek

Different dietary branched-chain amino acid ratios, crude protein levels, and protein sources can affect the growth performance and meat yield in broilers

不同的日粮支链氨基酸比例、粗蛋白水平和蛋白质来源会影响肉鸡的生长性能和产肉量

Doyun Goo, Amit K Singh, Janghan Choi, Milan K Sharma, Deependra Paneru, Jihwan Lee, Hemanth R Katha, Hong Zhuang, Byungwhi Kong, Brian Bowker, Woo Kyun Kim

Comparison of different promoters to improve AAV vector-mediated gene therapy for neuronopathic Gaucher disease

比较不同启动子对AAV载体介导的神经性戈谢病基因治疗的效果

Giulia Massaro, Amy F Geard, Hemanth R Nelvagal, Katrina Gore, Nadine K Clemo, Simon N Waddington, Ahad A Rahim

Gene therapy ameliorates spontaneous seizures associated with cortical neuron loss in a Cln2R207X mouse model

基因疗法可改善Cln2R207X小鼠模型中与皮质神经元丢失相关的自发性癫痫发作

Takahashi, Keigo; Eultgen, Elizabeth M; Wang, Sophie H; Rensing, Nicholas R; Nelvagal, Hemanth R; Dearborn, Joshua T; Danos, Olivier; Buss, Nicholas; Sands, Mark S; Wong, Michael; Cooper, Jonathan D

Cross-species efficacy of enzyme replacement therapy for CLN1 disease in mice and sheep

酶替代疗法治疗小鼠和绵羊CLN1疾病的跨物种疗效

Nelvagal, Hemanth R; Eaton, Samantha L; Wang, Sophie H; Eultgen, Elizabeth M; Takahashi, Keigo; Le, Steven Q; Nesbitt, Rachel; Dearborn, Joshua T; Siano, Nicholas; Puhl, Ana C; Dickson, Patricia I; Thompson, Gerard; Murdoch, Fraser; Brennan, Paul M; Gray, Mark; Greenhalgh, Stephen N; Tennant, Peter; Gregson, Rachael; Clutton, Eddie; Nixon, James; Proudfoot, Chris; Guido, Stefano; Lillico, Simon G; Whitelaw, C Bruce A; Lu, Jui-Yun; Hofmann, Sandra L; Ekins, Sean; Sands, Mark S; Wishart, Thomas M; Cooper, Jonathan D

Effects of chronic cannabidiol in a mouse model of naturally occurring neuroinflammation, neurodegeneration, and spontaneous seizures

慢性大麻二酚对自然发生的神经炎症、神经退行性病变和自发性癫痫的小鼠模型的影响

Joshua T Dearborn, Hemanth R Nelvagal, Nicholas R Rensing, Keigo Takahashi, Stephanie M Hughes, Thomas M Wishart, Jonathan D Cooper, Michael Wong, Mark S Sands

Tralesinidase Alfa Enzyme Replacement Therapy Prevents Disease Manifestations in a Canine Model of Mucopolysaccharidosis Type IIIB

曲莱西尼酶阿法酶替代疗法可预防犬粘多糖贮积症 IIIB 型模型的疾病表现

N Matthew Ellinwood, Bethann N Valentine, Andrew S Hess, Jackie K Jens, Elizabeth M Snella, Maryam Jamil, Shannon J Hostetter, Nicholas D Jeffery, Jodi D Smith, Suzanne T Millman, Rebecca L Parsons, Mark T Butt, Sundeep Chandra, Martin T Egeland, Ana B Assis, Hemanth R Nelvagal, Jonathan D Cooper, I

Glial Dysfunction and Its Contribution to the Pathogenesis of the Neuronal Ceroid Lipofuscinoses

神经胶质功能障碍及其对神经元蜡样脂褐质沉积症发病机制的影响

Takahashi, Keigo; Nelvagal, Hemanth R; Lange, Jenny; Cooper, Jonathan D