日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mechanistic machine learning enables interpretable and generalizable prediction of prime editing outcomes

机制机器学习能够对主要编辑结果进行可解释且可推广的预测。

Hsu, Alvin; Chen, Peter J; Li, Angus H; Hemez, Colin F; Gao, Xin D; Terrey, Markus; Nelson, Charlie; Selvam, Vijay; Cristian, Ana; McElroy, Amber N; Steinbeck, Benjamin J; Mahadeshwar, Gandhar K; Pandey, Smriti; Barsdale, Zachary; Chen, Paul Z; Sousa, Alexander A; Sakai, Holt A; Silverstein, Rachel A; Morad, Ilias; Krueger, Ryan K; Shen, Max W; Kleinstiver, Benjamin P; Lutz, Cathleen M; Tolar, Jakub; Blazar, Bruce R; Osborn, Mark J; Liu, David R

Engineering a genomically recoded organism with one stop codon

构建一个基因组重编码生物体,使其带有一个终止密码子

Grome, Michael W; Nguyen, Michael T A; Moonan, Daniel W; Mohler, Kyle; Gurara, Kebron; Wang, Shenqi; Hemez, Colin; Stenton, Benjamin J; Cao, Yunteng; Radford, Felix; Kornaj, Maya; Patel, Jaymin; Prome, Maisha; Rogulina, Svetlana; Sozanski, David; Tordoff, Jesse; Rinehart, Jesse; Isaacs, Farren J

Systematic optimization of prime editing for the efficient functional correction of CFTR F508del in human airway epithelial cells

系统优化主编辑策略,以实现人呼吸道上皮细胞中CFTR F508del突变的有效功能性矫正

Sousa, Alexander A; Hemez, Colin; Lei, Lei; Traore, Soumba; Kulhankova, Katarina; Newby, Gregory A; Doman, Jordan L; Oye, Keyede; Pandey, Smriti; Karp, Philip H; McCray, Paul B Jr; Liu, David R

Amphiphilic shuttle peptide delivers base editor ribonucleoprotein to correct the CFTR R553X mutation in well-differentiated airway epithelial cells.

两亲性穿梭肽将碱基编辑器核糖核蛋白递送至分化良好的气道上皮细胞,以纠正 CFTR R553X 突变

Kulhankova Katarina, Cheng Anna X, Traore Soumba, Auger Maud, Pelletier Mia, Hervault Maxime, Wells Kevin D, Green Jonathan A, Byrne Addison, Nelson Benjamin, Sponchiado Mariana, Boosani Chandra, Heffner Caleb S, Snow Kathy J, Murray Stephen A, Villacreses Raul A, Rector Michael V, Gansemer Nicholas D, Stoltz David A, Allamargot Chantal, Couture Frédéric, Hemez Colin, Hallée Stéphanie, Barbeau Xavier, Harvey Mario, Lauvaux Coraline, Gaillet Bruno, Newby Gregory A, Liu David R, McCray Paul B Jr, Guay David

New developments on vermifiltration as a bio-ecological wastewater treatment technology: Mechanism, application, performance, modelling, optimization, and sustainability

蚯蚓过滤作为一种生物生态废水处理技术的新进展:机理、应用、性能、建模、优化和可持续性

Y Saapi, Sidesse S; Andrianisa, Harinaivo A; Zorom, Malicki; Mounirou, Lawani A; Kouassi, Hemez Ange Aurélien; Ahossouhe, Mahugnon Samuel

Genomically recoded Escherichia coli with optimized functional phenotypes

具有优化功能表型的基因组重新编码大肠杆菌

Colin Hemez, Kyle Mohler, Felix Radford, Jack Moen, Jesse Rinehart, Farren J Isaacs

Sustainability of facilities built under the Community-Led Total Sanitation (CLTS) implementation: Moving from basic to safe facilities on the sanitation ladder

社区主导型全面卫生(CLTS)实施下所建设施的可持续性:从基本设施迈向安全设施的卫生阶梯

Kouassi, Hemez Ange Aurélien; Andrianisa, Harinaivo Anderson; Sossou, Seyram Kossi; Traoré, Maïmouna Bologo; Nguematio, Rikyelle Momo

Mechanisms of antibiotic action shape the fitness landscapes of resistance mutations

抗生素的作用机制塑造了耐药突变的适应性格局。

Hemez, Colin; Clarelli, Fabrizio; Palmer, Adam C; Bleis, Christina; Abel, Sören; Chindelevitch, Leonid; Cohen, Theodore; Abel Zur Wiesch, Pia

Classifying organisms and artefacts by their outline shapes

根据轮廓形状对生物体和人造物进行分类

Shutt, D P; Goodsman, D W; Martinez, K; Hemez, Z J L; Conrad, J R; Xu, C; Osthus, D; Russell, C; Hyman, J M; Manore, C A; Salili-James, Arianna; Mackay, Anne; Rodriguez-Alvarez, Emilio; Rodriguez-Perez, Diana; Mannack, Thomas; Rawlings, Timothy A; Palmer, A Richard; Todd, Jonathan; Riutta, Terhi E; Macinnis-Ng, Cate; Han, Zhitong; Davies, Megan; Thorpe, Zinnia; Marsland, Stephen; Leroi, Armand M

Disulfide-compatible phage-assisted continuous evolution in the periplasmic space

二硫键相容的噬菌体辅助在周质空间中持续进化

Mary S Morrison, Tina Wang, Aditya Raguram, Colin Hemez, David R Liu