日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mechanistic machine learning enables interpretable and generalizable prediction of prime editing outcomes

机制机器学习能够对主要编辑结果进行可解释且可推广的预测。

Hsu, Alvin; Chen, Peter J; Li, Angus H; Hemez, Colin F; Gao, Xin D; Terrey, Markus; Nelson, Charlie; Selvam, Vijay; Cristian, Ana; McElroy, Amber N; Steinbeck, Benjamin J; Mahadeshwar, Gandhar K; Pandey, Smriti; Barsdale, Zachary; Chen, Paul Z; Sousa, Alexander A; Sakai, Holt A; Silverstein, Rachel A; Morad, Ilias; Krueger, Ryan K; Shen, Max W; Kleinstiver, Benjamin P; Lutz, Cathleen M; Tolar, Jakub; Blazar, Bruce R; Osborn, Mark J; Liu, David R

Engineering a genomically recoded organism with one stop codon

构建一个基因组重编码生物体,使其带有一个终止密码子

Grome, Michael W; Nguyen, Michael T A; Moonan, Daniel W; Mohler, Kyle; Gurara, Kebron; Wang, Shenqi; Hemez, Colin; Stenton, Benjamin J; Cao, Yunteng; Radford, Felix; Kornaj, Maya; Patel, Jaymin; Prome, Maisha; Rogulina, Svetlana; Sozanski, David; Tordoff, Jesse; Rinehart, Jesse; Isaacs, Farren J

Systematic optimization of prime editing for the efficient functional correction of CFTR F508del in human airway epithelial cells

系统优化主编辑策略,以实现人呼吸道上皮细胞中CFTR F508del突变的有效功能性矫正

Sousa, Alexander A; Hemez, Colin; Lei, Lei; Traore, Soumba; Kulhankova, Katarina; Newby, Gregory A; Doman, Jordan L; Oye, Keyede; Pandey, Smriti; Karp, Philip H; McCray, Paul B Jr; Liu, David R

Amphiphilic shuttle peptide delivers base editor ribonucleoprotein to correct the CFTR R553X mutation in well-differentiated airway epithelial cells.

两亲性穿梭肽将碱基编辑器核糖核蛋白递送至分化良好的气道上皮细胞,以纠正 CFTR R553X 突变

Kulhankova Katarina, Cheng Anna X, Traore Soumba, Auger Maud, Pelletier Mia, Hervault Maxime, Wells Kevin D, Green Jonathan A, Byrne Addison, Nelson Benjamin, Sponchiado Mariana, Boosani Chandra, Heffner Caleb S, Snow Kathy J, Murray Stephen A, Villacreses Raul A, Rector Michael V, Gansemer Nicholas D, Stoltz David A, Allamargot Chantal, Couture Frédéric, Hemez Colin, Hallée Stéphanie, Barbeau Xavier, Harvey Mario, Lauvaux Coraline, Gaillet Bruno, Newby Gregory A, Liu David R, McCray Paul B Jr, Guay David

Mechanisms of antibiotic action shape the fitness landscapes of resistance mutations

抗生素的作用机制塑造了耐药突变的适应性格局。

Hemez, Colin; Clarelli, Fabrizio; Palmer, Adam C; Bleis, Christina; Abel, Sören; Chindelevitch, Leonid; Cohen, Theodore; Abel Zur Wiesch, Pia