IL-36γ armored CAR T cells reprogram neutrophils to induce endogenous antitumor immunity.
IL-36α 装甲 CAR T 细胞可重编程中性粒细胞,诱导内源性抗肿瘤免疫。
期刊:Cancer Cell
影响因子:44.5
doi:10.1016/j.ccell.2025.11.007
Zuo Yihan, Vohwinkel David J, Dong Bowen, McDowell James R, Guzman Brandon V, Manickavel Pandian Tharuna Sri, Chattopadhyay Saborni, McGray A J R, Olejniczak Scott H, Ohm Joyce, Wang Jianmin, Long Mark D, Gomez Eduardo Cortes, Purdon Terence J, Luo Wei, Mohammadpour Hemn, Hackett Christopher S, Cherkassky Leonid, Davila Marco, Abrams Scott I, Brentjens Renier J
肿瘤
IL-3
T细胞
肿瘤免疫
中性粒细胞
粒细胞
细胞生物学
免疫/内分泌