日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Conformational equilibria in the activation of cystine-knot hormone receptors

胱氨酸结激素受体激活过程中的构象平衡

Gong, Zhen; Hendrickson, Wayne A

The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC

强效CD4模拟物对HIV-1 Env的不对称打开作用,使得抗辅助受体结合位点抗体能够介导抗体依赖性细胞毒性作用(ADCC)。

Richard, Jonathan; Grunst, Michael W; Niu, Ling; Díaz-Salinas, Marco A; Zhu, Li; Tolbert, William D; Marchitto, Lorie; Zhou, Fei; Bourassa, Catherine; Kim, Hongil; Boodapati, Sri Lakshmi Tejaswi; Yang, Derek; Chiu, Ta Jung; Chen, Hung-Ching; Benlarbi, Mehdi; Beaudoin-Bussières, Guillaume; Gottumukkala, Suneetha; Li, Wenwei; Dionne, Katrina; Bélanger, Étienne; Chatterjee, Debashree; Medjahed, Halima; Hendrickson, Wayne A; Sodroski, Joseph; Lang, Zabrina C; Morton, Abraham J; Huang, Rick K; Matthies, Doreen; Smith, Amos B 3rd; Kumar, Priti; Mothes, Walther; Munro, James B; Pazgier, Marzena; Finzi, Andrés

Structure of an LGR dimer, an evolutionary predecessor of glycoprotein hormone receptors

LGR二聚体的结构,它是糖蛋白激素受体的进化前体

Gong, Zhen; Chen, Shuobing; Fu, Ziao; Kloss, Brian; Wang, Chi; Kim, Jonathan; Clarke, Oliver B; Fan, Qing R; Hendrickson, Wayne A

Cholesterol-dependent enzyme activity of human TSPO1

人TSPO1的胆固醇依赖性酶活性

Qiu, Weihua; Trinh, Thi Kim Hoang; Catalano, Claudio; Mehta, Akul; Desai, Umesh R; Kellogg, Glen E; Hendrickson, Wayne A; Guo, Youzhong

AlphaFold-guided molecular replacement for solving challenging crystal structures

利用 AlphaFold 指导的分子置换法解析复杂的晶体结构

Wang, Wei; Gong, Zhen; Hendrickson, Wayne A

Small molecule inhibitor of PPARγ acetylation promotes insulin sensitization and browning of white adipose tissue with improved safety.

PPARγ乙酰化小分子抑制剂可促进胰岛素敏感性和白色脂肪组织褐变,且安全性更高。

Wu Dan, Gong Zhen, He Ying, Kumar Sandeep, Eeda Venkateswararao, Wan Qianfen, Herlea-Pana Oana, Lim Hui-Ying, Hendrickson Wayne A, Qiang Li, Wang Weidong

Promiscuous G-protein activation by the calcium-sensing receptor

钙敏感受体对G蛋白的非特异性激活

Zuo, Hao; Park, Jinseo; Frangaj, Aurel; Ye, Jianxiang; Lu, Guanqi; Manning, Jamie J; Asher, Wesley B; Lu, Zhengyuan; Hu, Guo-Bin; Wang, Liguo; Mendez, Joshua; Eng, Edward; Zhang, Zhening; Lin, Xin; Grassucci, Robert; Hendrickson, Wayne A; Clarke, Oliver B; Javitch, Jonathan A; Conigrave, Arthur D; Fan, Qing R

Mechanistic insights into phosphoactivation of SLAC1 in guard cell signaling

SLAC1磷酸化激活在保卫细胞信号传导中的机制研究

Qin, Li; Deng, Ya-Nan; Zhang, Xiang-Yun; Tang, Ling-Hui; Zhang, Chun-Rui; Xu, Shi-Min; Wang, Ke; Wang, Mei-Hua; Zhang, Xian-Hui; Su, Min; Xie, Qi; Hendrickson, Wayne A; Chen, Yu-Hang

Structural identification of the RY12 domain of RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantrolene

通过结构鉴定,确定 RyR1 的 RY12 结构域为 ADP 传感器,并且是恶性高热疗法药物丹曲林的靶点。

Kim, Kookjoo; Li, Huan; Yuan, Qi; Melville, Zephan; Zalk, Ran; des Georges, Amédée; Frank, Joachim; Hendrickson, Wayne A; Marks, Andrew R; Clarke, Oliver B

Facing the phase problem

面对相位问题

Hendrickson, Wayne A