日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Implementing a trilineage differentiation in the ReproTracker assay for improved teratogenicity assessment

在ReproTracker检测中实施三系分化以改进致畸性评估

Horcas-Nieto, José M; Hartvelt, Sabine; Flatt, Luke; Fang, Jing; Lam, Esther; Zhang, Gaonan; Van Vliet, Romy; Feliksik, Marleen; Zwetsloot, Tom; Philippo, Connor; Hendriks, Giel; Jamalpoor, Amer

Understanding the cellular uptake and genotoxic potential of industrial relevant nanomaterials utilizing electron microscopy and the ToxTracker assay in vitro

利用体外电子显微镜和ToxTracker检测方法,了解工业相关纳米材料的细胞摄取和遗传毒性潜力。

Evans, Stephen J; Moelijker, Nynke; Brandsma, Inger; Burgum, Michael J; Elespuru, Rosalie; Hendriks, Giel; Doak, Shareen H

Animal-free assessment of developmental toxicity: Combining PBPK modeling with the ReproTracker assay

无动物实验评估发育毒性:将PBPK模型与ReproTracker检测相结合

Moreau, Marjory; Jamalpoor, Amer; Hall, John Carter; Fisher, Jeffrey; Hartvelt, Sabine; Hendriks, Giel; Nong, Andy

AOP report: Development of an adverse outcome pathway for oxidative DNA damage leading to mutations and chromosomal aberrations

AOP报告:氧化性DNA损伤导致突变和染色体畸变的不良结局通路的研究

Cho, Eunnara; Allemang, Ashley; Audebert, Marc; Chauhan, Vinita; Dertinger, Stephen; Hendriks, Giel; Luijten, Mirjam; Marchetti, Francesco; Minocherhomji, Sheroy; Pfuhler, Stefan; Roberts, Daniel J; Trenz, Kristina; Yauk, Carole L

ToxTracker Reporter Cell Lines as a Tool for Mechanism-Based (geno)Toxicity Screening of Nanoparticles-Metals, Oxides and Quantum Dots

ToxTracker报告基因细胞系作为基于机制的纳米颗粒(金属、氧化物和量子点)毒性(基因)筛选的工具

McCarrick, Sarah; Cappellini, Francesca; Kessler, Amanda; Moelijker, Nynke; Derr, Remco; Hedberg, Jonas; Wold, Susanna; Blomberg, Eva; Odnevall Wallinder, Inger; Hendriks, Giel; Karlsson, Hanna L

The functional impact of variants of uncertain significance in BRCA2.

BRCA2 中意义未明变异的功能影响

Mesman Romy L S, Calléja Fabienne M G R, Hendriks Giel, Morolli Bruno, Misovic Branislav, Devilee Peter, van Asperen Christi J, Vrieling Harry, Vreeswijk Maaike P G

Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474

基于活性的蛋白质谱分析揭示了FAAH抑制剂BIA 10-2474的脱靶蛋白

van Esbroeck, Annelot C M; Janssen, Antonius P A; Cognetta, Armand B 3rd; Ogasawara, Daisuke; Shpak, Guy; van der Kroeg, Mark; Kantae, Vasudev; Baggelaar, Marc P; de Vrij, Femke M S; Deng, Hui; Allarà, Marco; Fezza, Filomena; Lin, Zhanmin; van der Wel, Tom; Soethoudt, Marjolein; Mock, Elliot D; den Dulk, Hans; Baak, Ilse L; Florea, Bogdan I; Hendriks, Giel; De Petrocellis, Luciano; Overkleeft, Herman S; Hankemeier, Thomas; De Zeeuw, Chris I; Di Marzo, Vincenzo; Maccarrone, Mauro; Cravatt, Benjamin F; Kushner, Steven A; van der Stelt, Mario

Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-κB activation and sensitizes toward TNFα-induced cytotoxicity

内源性肝毒性药物激活Nrf2反应与NF-κB激活抑制相关,并增强对TNFα诱导的细胞毒性的敏感性。

Herpers, Bram; Wink, Steven; Fredriksson, Lisa; Di, Zi; Hendriks, Giel; Vrieling, Harry; de Bont, Hans; van de Water, Bob

The Extended ToxTracker Assay Discriminates Between Induction of DNA Damage, Oxidative Stress, and Protein Misfolding

扩展型 ToxTracker 检测可区分 DNA 损伤、氧化应激和蛋白质错误折叠的诱导

Hendriks, Giel; Derr, Remco S; Misovic, Branislav; Morolli, Bruno; Calléja, Fabienne M G R; Vrieling, Harry

An efficient pipeline for the generation and functional analysis of human BRCA2 variants of uncertain significance

一种用于生成和功能分析人类 BRCA2 意义未明变异的高效流程

Hendriks, Giel; Morolli, Bruno; Calléja, Fabienne M G R; Plomp, Anouk; Mesman, Romy L S; Meijers, Matty; Sharan, Shyam K; Vreeswijk, Maaike P G; Vrieling, Harry