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Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infections.

先天免疫引起的骨髓中性粒细胞耗竭会加重全身性细菌感染

期刊:Proceedings of the National Academy of Sciences of the United States of America

Navarini Alexander A, Lang Karl S, Verschoor Admar, Recher Mike, Zinkernagel Annelies S, Nizet Victor, Odermatt Bernhard, Hengartner Hans, Zinkernagel Rolf M

细胞生物学

发表日期：2009

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Early antibodies specific for the neutralizing epitope on the receptor binding subunit of the lymphocytic choriomeningitis virus glycoprotein fail to neutralize the virus

早期针对淋巴细胞性脉络丛脑膜炎病毒糖蛋白受体结合亚基上中和表位的特异性抗体无法中和病毒。

期刊:Journal of Virology

影响因子:3.8

doi:10.1128/JVI.00955-07

Eschli, Bruno; Zellweger, Raphaël M; Wepf, Alexander; Lang, Karl S; Quirin, Katharina; Weber, Jacqueline; Zinkernagel, Rolf M; Hengartner, Hans

Microchimerism maintains deletion of the donor cell-specific CD8+ T cell repertoire

微嵌合体维持了供体细胞特异性 CD8+ T 细胞库的缺失

期刊:Journal of Clinical Investigation

影响因子:13.6

doi:10.1172/JCI26565

Bonilla, Weldy V; Geuking, Markus B; Aichele, Peter; Ludewig, Burkhard; Hengartner, Hans; Zinkernagel, Rolf M

Nonneutralizing antibodies binding to the surface glycoprotein of lymphocytic choriomeningitis virus reduce early virus spread

与淋巴细胞性脉络丛脑膜炎病毒表面糖蛋白结合的非中和抗体可减少病毒早期传播。

期刊:Journal of Experimental Medicine

影响因子:10.6

doi:10.1084/jem.20051557

Hangartner, Lars; Zellweger, Raphaël M; Giobbi, Mattia; Weber, Jacqueline; Eschli, Bruno; McCoy, Kathy D; Harris, Nicola; Recher, Mike; Zinkernagel, Rolf M; Hengartner, Hans

Increased susceptibility to bacterial superinfection as a consequence of innate antiviral responses.

由于先天性抗病毒反应，对细菌继发感染的易感性增加

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.0607325103

Navarini Alexander A, Recher Mike, Lang Karl S, Georgiev Panco, Meury Susanne, Bergthaler Andreas, Flatz Lukas, Bille Jacques, Landmann Regine, Odermatt Bernhard, Hengartner Hans, Zinkernagel Rolf M

Endogenous neosynthesis vs. cross-presentation of viral antigens for cytotoxic T cell priming

内源性新合成与病毒抗原交叉呈递在细胞毒性T细胞启动中的作用

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.1835685100

Freigang, Stefan; Egger, Denise; Bienz, Kurt; Hengartner, Hans; Zinkernagel, Rolf M

Antagonistic variant virus prevents wild-type virus-induced lethal immunopathology

拮抗性变异病毒可阻止野生型病毒诱发的致命性免疫病理。

期刊:Journal of Experimental Medicine

影响因子:10.6

doi:10.1084/jem.20012045

Hunziker, Lukas; Recher, Mike; Ciurea, Adrian; Martinic, Marianne M A; Odermatt, Bernhard; Hengartner, Hans; Zinkernagel, Rolf M

X-ray structure of the arenavirus glycoprotein GP2 in its postfusion hairpin conformation

沙粒病毒糖蛋白GP2融合后发夹构象的X射线结构

Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infections.

先天免疫引起的骨髓中性粒细胞耗竭会加重全身性细菌感染

Early antibodies specific for the neutralizing epitope on the receptor binding subunit of the lymphocytic choriomeningitis virus glycoprotein fail to neutralize the virus

早期针对淋巴细胞性脉络丛脑膜炎病毒糖蛋白受体结合亚基上中和表位的特异性抗体无法中和病毒。

Microchimerism maintains deletion of the donor cell-specific CD8+ T cell repertoire

微嵌合体维持了供体细胞特异性 CD8+ T 细胞库的缺失

Nonneutralizing antibodies binding to the surface glycoprotein of lymphocytic choriomeningitis virus reduce early virus spread

与淋巴细胞性脉络丛脑膜炎病毒表面糖蛋白结合的非中和抗体可减少病毒早期传播。

Increased susceptibility to bacterial superinfection as a consequence of innate antiviral responses.

由于先天性抗病毒反应，对细菌继发感染的易感性增加

Endogenous neosynthesis vs. cross-presentation of viral antigens for cytotoxic T cell priming

内源性新合成与病毒抗原交叉呈递在细胞毒性T细胞启动中的作用

Antagonistic variant virus prevents wild-type virus-induced lethal immunopathology

拮抗性变异病毒可阻止野生型病毒诱发的致命性免疫病理。