日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Monovalent pseudo-natural products supercharge degradation of IDO1 by its native E3 KLHDC3.

单价伪天然产物可加速 IDO1 的天然 E3 KLHDC3 的降解。

Hennes Elisabeth, Lucas Belén, Scholes Natalie S, Cheng Xiu-Fen, Scott Daniel C, Bischoff Matthias, Reich Katharina, Gasper Raphael, Lucas María, Xu Teng Teng, Rossini Sofia, Pulvermacher Lisa-Marie, Dötsch Lara, Imrichova Hana, Brause Alexandra, Führer Siska, Naredla Kesava Reddy, Sievers Sonja, Kumar Kamal, Janning Petra, Orabona Ciriana, Gersch Malte, Murray Peter J, Schulman Brenda A, Winter Georg E, Ziegler Slava, Waldmann Herbert

Adverse pro-tumorigenic effects of IDO1 catalytic inhibitors mediated by the non-enzymatic function of IDO1 in tumor cells

IDO1催化抑制剂通过IDO1在肿瘤细胞中的非酶促功能发挥促肿瘤作用

Rossini, Sofia; Ambrosino, Sara; Volpi, Claudia; Suvieri, Chiara; Pallotta, Maria Teresa; Belladonna, Maria Laura; Sorcini, Daniele; Macchiarulo, Antonio; Hennes, Elisabeth; Ziegler, Slava; Waldmann, Herbert; Orabona, Ciriana

Identification of a Monovalent Pseudo-Natural Product Degrader Class Supercharging Degradation of IDO1 by its native E3 KLHDC3

鉴定出一种单价伪天然产物降解剂,该降解剂可显著增强其天然 E3 酶 KLHDC3 对 IDO1 的降解作用

Hennes, Elisabeth; Lucas, Belén; Scholes, Natalie S; Cheng, Xiu-Fen; Scott, Daniel C; Bischoff, Matthias; Reich, Katharina; Gasper, Raphael; Lucas, María; Xu, Teng Teng; Pulvermacher, Lisa-Marie; Dötsch, Lara; Imrichova, Hana; Brause, Alexandra; Naredla, Kesava Reddy; Sievers, Sonja; Kumar, Kamal; Janning, Petra; Gersch, Malte; Murray, Peter J; Schulman, Brenda A; Winter, Georg E; Ziegler, Slava; Waldmann, Herbert

Chronic stimulation desensitizes β2-adrenergic receptor responses in natural killer cells.

慢性刺激会使自然杀伤细胞中的β2-肾上腺素能受体反应脱敏

Jürgens Martin, Claus Maren, Wingert Sabine, Niemann Jens Alexander, Picard Lea Katharina, Hennes Elisabeth, Haasler Ina, Hellwig Birte, Overbeck Nina, Reinders Jörg, Rahnenführer Jörg, Schedel Michaela, Capellino Silvia, Watzl Carsten

Identification of a Novel Pseudo-Natural Product Type IV IDO1 Inhibitor Chemotype

鉴定一种新型拟天然产物IV型IDO1抑制剂化学类型

Davies, Caitlin; Dötsch, Lara; Ciulla, Maria Gessica; Hennes, Elisabeth; Yoshida, Kei; Gasper, Raphael; Scheel, Rebecca; Sievers, Sonja; Strohmann, Carsten; Kumar, Kamal; Ziegler, Slava; Waldmann, Herbert

Cell-Based Identification of New IDO1 Modulator Chemotypes

基于细胞的新型IDO1调节剂化学类型的鉴定

Hennes, Elisabeth; Lampe, Philipp; Dötsch, Lara; Bruning, Nora; Pulvermacher, Lisa-Marie; Sievers, Sonja; Ziegler, Slava; Waldmann, Herbert

Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIß

发现靶向 PI4KIIIβ 的 Hedgehog 通路抑制剂 Pipinib

Kremer, Lea; Hennes, Elisabeth; Brause, Alexandra; Ursu, Andrei; Robke, Lucas; Matsubayashi, Hideaki T; Nihongaki, Yuta; Flegel, Jana; Mejdrová, Ivana; Eickhoff, Jan; Baumann, Matthias; Nencka, Radim; Janning, Petra; Kordes, Susanne; Schöler, Hans R; Sterneckert, Jared; Inoue, Takanari; Ziegler, Slava; Waldmann, Herbert

Lipidated Stapled Peptides Targeting the Acyl Binding Protein UNC119

靶向酰基结合蛋白UNC119的脂化交联肽

Cromm, Philipp M; Adihou, Hélène; Kapoor, Shobhna; Vazquez-Chantada, Mercedes; Davey, Paul; Longmire, David; Hennes, Elisabeth; Hofer, Walter; Küchler, Philipp; Chiarparin, Elisabetta; Waldmann, Herbert; Grossmann, Tom N