日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

3H-pyrazolo[4,3-f]quinoline hinge binder, a tunable scaffold for development of novel kinase inhibitors against FLT3-driven leukemia

3H-吡唑并[4,3-f]喹啉铰链结合剂,一种可用于开发新型抗FLT3驱动白血病激酶抑制剂的可调支架

Dayal, Neetu; Řezníčková, Eva; Hernandez, Delmis E; Peřina, Miroslav; Bělíček, Jakub; Vojáčková, Veronika; Krňávková, Petra; Bařina, Marek; Brauer, Nickolas R; Hunjan, Mandeep Kaur; Yadav, Pratik; Jorda, Radek; Sintim, Herman O

Structural and biochemical insights into the inhibition of Mycobacterium tuberculosis cyclic dinucleotide phosphodiesterase by a sulfur-modified cyclic dinucleotide analog

硫修饰的环状二核苷酸类似物对结核分枝杆菌环状二核苷酸磷酸二酯酶抑制作用的结构和生化研究

Hanuman, Dagur Singh; Neeharika, Singh; Murari, Sinha Krishna; Yeboah, Simpa K; Sintim, Herman O; Rajakumara, Eerappa

Activation of cellular responses by cyclic dinucleotides and porphyromonas gingivalis lipopolysaccharide: a proteomic study on gingival fibroblasts

环状二核苷酸和牙龈卟啉单胞菌脂多糖激活细胞反应:牙龈成纤维细胞蛋白质组学研究

Elmanfi, Samira; Onyedibe, Kenneth I; Aryal, Uma K; Könönen, Eija; Sintim, Herman O; Gürsoy, Ulvi Kahraman

Inhibitors of Cyclic Dinucleotide Phosphodiesterases and Cyclic Oligonucleotide Ring Nucleases as Potential Drugs for Various Diseases

环状二核苷酸磷酸二酯酶和环状寡核苷酸环核酸酶抑制剂作为多种疾病的潜在药物

Vennard, Christopher S; Oladeji, Samson Marvellous; Sintim, Herman O

5'-Phosphorothioester Linked Cyclic Dinucleotides, Endo-S-CDNs, Displaying Impressive Antitumor Activities In Vivo when Dosed Subcutaneously

5'-磷酸硫酯连接的环状二核苷酸(Endo-S-CDNs)皮下给药后在体内显示出显著的抗肿瘤活性

Yeboah, Simpa K; Meher, Sagarika; Harper, Haley Anne; McMahan, Carli; Elzey, Bennett D; Sintim, Herman O

Identification of alkynyl nicotinamide HSN748 as a RET solvent-front mutant inhibitor with intracranial efficacy.

鉴定炔基烟酰胺 HSN748 为具有颅内疗效的 RET 溶剂前沿突变体抑制剂

Khatri Ujjwol, Dayal Neetu, Owusu Kofi B, Hunjan Mandeep Kaur, Pandey Shriya, Harper Haley Anne, McMahan Carli, Elzey Bennett D, Shen Tao, Hu Xueqing, Evans Kurt W, El-Sheikh Ahmed, Jo Seong Jun, Holtsberg Frederick W, Aman M Javad, Meric-Bernstam Funda, Woo Sukyung, Sintim Herman O, Wu Jie

Borrelia burgdorferi c-di-AMP is a key extracellular pathogen-associated molecular pattern to elicit type I interferon responses in mammalian hosts

伯氏疏螺旋体c-di-AMP是一种关键的细胞外病原体相关分子模式,可诱导哺乳动物宿主产生I型干扰素反应。

Priya, Raj; Ye, Meiping; Raghunanadanan, Sajith; Liu, Qiang; Li, Wei; Yu, Qigui; Lou, Yongliang; Sintim, Herman O; Yang, X Frank

Proteomic profiling of adipose-derived mesenchymal stromal cell response to novel compounds targeting the Laminin Receptor - PEDF interaction

脂肪来源间充质干细胞对靶向层粘连蛋白受体-PEDF相互作用的新型化合物的反应的蛋白质组学分析

Figueiredo, Marxa L; Figueiredo Neto, Manoel; Umbaugh, C Samuel; Sobreira, Tiago J P; Elsbury, Claire E; Mulia, Grace E; Harris, Gabriel S; Lescun, Timothy B; Sintim, Herman O

Alkynyl nicotinamides show antileukemic activity in drug-resistant acute myeloid leukemia

炔基烟酰胺在耐药性急性髓系白血病中显示出抗白血病活性

Ramdas, Baskar; Dayal, Neetu; Pandey, Ruchi; Larocque, Elizabeth; Kanumuri, Rahul; Pasupuleti, Santhosh Kumar; Liu, Sheng; Kanellopoulou, Chrysi; Chu, Elizabeth Fei Yin; Mohallem, Rodrigo; Virani, Saniya; Chopra, Gaurav; Aryal, Uma K; Lapidus, Rena; Wan, Jun; Emadi, Ashkan; Haneline, Laura S; Holtsberg, Frederick W; Aman, M Javad; Sintim, Herman O; Kapur, Reuben

Identification and characterization of a potent and selective HUNK inhibitor for treatment of HER2+ breast cancer

鉴定和表征用于治疗 HER2+ 乳腺癌的强效选择性 HUNK 抑制剂

Tinslee Dilday, Melissa Abt, Nicole Ramos-Solís, Neetu Dayal, Elizabeth Larocque, Adrian L Oblak, Herman O Sintim, Elizabeth S Yeh