日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

RB loss sensitizes cells to replication-associated DNA damage by PARP inhibition

RB缺失通过抑制PARP使细胞对复制相关的DNA损伤更加敏感

Zamalloa, L Gregory; Pruitt, Margaret M; Hermance, Nicole M; Gali, Himabindu; Flynn, Rachel L; Manning, Amity L

Suppression of Chromosome Instability Limits Acquired Drug Resistance

抑制染色体不稳定性可限制获得性耐药性的产生

Crowley, Elizabeth A; Hermance, Nicole M; Herlihy, Conor P; Manning, Amity L

Alisertib plus induction chemotherapy in previously untreated patients with high-risk, acute myeloid leukaemia: a single-arm, phase 2 trial

Alisertib联合诱导化疗治疗既往未接受治疗的高危急性髓系白血病患者:一项单臂II期试验

Brunner, Andrew M; Blonquist, Traci M; DeAngelo, Daniel J; McMasters, Malgorzata; Fell, Geoffrey; Hermance, Nicole M; Winer, Eric S; Lindsley, R Coleman; Hobbs, Gabriela S; Amrein, Philip C; Hock, Hanno R; Steensma, David P; Garcia, Jacqueline S; Luskin, Marlise R; Stone, Richard M; Ballen, Karen K; Rosenblatt, Jacalyn; Avigan, David; Nahas, Myrna R; Mendez, Lourdes M; McAfee, Steven L; Moran, Jenna A; Bergeron, Meghan; Foster, Julia; Bertoli, Christina; Manning, Amity L; McGregor, Kristin L; Fishman, Kaitlyn M; Kuo, Frank C; Baltay, Michele T; Macrae, Molly; Burke, Meghan; Behnan, Tanya; Wey, Margaret C; Som, Tina T; Ramos, Aura Y; Rae, Jessica; Lombardi Story, Jennifer; Nelson, Nicole; Logan, Emma; Connolly, Christine; Neuberg, Donna S; Chen, Yi-Bin; Graubert, Timothy A; Fathi, Amir T

Aurora A inhibition limits centrosome clustering and promotes mitotic catastrophe in cells with supernumerary centrosomes

Aurora A 抑制剂限制中心体聚集,并促进具有超数中心体的细胞发生有丝分裂灾难。

Navarro-Serer, Bernat; Childers, Eva P; Hermance, Nicole M; Mercadante, Dayna; Manning, Amity L

Phase I study of the aurora A kinase inhibitor alisertib with induction chemotherapy in patients with acute myeloid leukemia

Aurora A激酶抑制剂alisertib联合诱导化疗治疗急性髓系白血病患者的I期研究

Fathi, Amir T; Wander, Seth A; Blonquist, Traci M; Brunner, Andrew M; Amrein, Philip C; Supko, Jeffrey; Hermance, Nicole M; Manning, Amity L; Sadrzadeh, Hossein; Ballen, Karen K; Attar, Eyal C; Graubert, Timothy A; Hobbs, Gabriela; Joseph, Christelle; Perry, Ashley M; Burke, Meghan; Silver, Regina; Foster, Julia; Bergeron, Meghan; Ramos, Aura Y; Som, Tina T; Fishman, Kaitlyn M; McGregor, Kristin L; Connolly, Christine; Neuberg, Donna S; Chen, Yi-Bin

Deletion of the gene encoding G0/G 1 switch protein 2 (G0s2) alleviates high-fat-diet-induced weight gain and insulin resistance, and promotes browning of white adipose tissue in mice

敲除编码 G0/G1 转换蛋白 2 (G0s2) 的基因可减轻高脂饮食诱导的小鼠体重增加和胰岛素抵抗,并促进白色脂肪组织的褐变。

El-Assaad, Wissal; El-Kouhen, Karim; Mohammad, Amro H; Yang, Jieyi; Morita, Masahiro; Gamache, Isabelle; Mamer, Orval; Avizonis, Daina; Hermance, Nicole; Kersten, Sander; Tremblay, Michel L; Kelliher, Michelle A; Teodoro, Jose G

Cutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo

前沿研究:RIPK1激酶失活小鼠在体内仍能存活,并能免受TNF诱导的坏死性凋亡的影响。

Polykratis, Apostolos; Hermance, Nicole; Zelic, Matija; Roderick, Justine; Kim, Chun; Van, Trieu-My; Lee, Thomas H; Chan, Francis K M; Pasparakis, Manolis; Kelliher, Michelle A

A cytosolic ATM/NEMO/RIP1 complex recruits TAK1 to mediate the NF-kappaB and p38 mitogen-activated protein kinase (MAPK)/MAPK-activated protein 2 responses to DNA damage

胞质ATM/NEMO/RIP1复合物募集TAK1,介导NF-κB和p38丝裂原活化蛋白激酶(MAPK)/MAPK活化蛋白2对DNA损伤的反应。

Yang, Yibin; Xia, Fang; Hermance, Nicole; Mabb, Angela; Simonson, Sara; Morrissey, Sarah; Gandhi, Pallavi; Munson, Mary; Miyamoto, Shigeki; Kelliher, Michelle A

Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc.

Notch1 通过直接诱导 c-myc 的表达,促进小鼠 T 细胞白血病的发生

Sharma Vishva Mitra, Calvo Jennifer A, Draheim Kyle M, Cunningham Leslie A, Hermance Nicole, Beverly Levi, Krishnamoorthy Veena, Bhasin Manoj, Capobianco Anthony J, Kelliher Michelle A