Interference with ERK-dimerization at the nucleocytosolic interface targets pathological ERK1/2 signaling without cardiotoxic side-effects
干扰核胞浆界面处的 ERK 二聚化可靶向病理性 ERK1/2 信号传导,且不会产生心脏毒性副作用
期刊:Nature Communications
影响因子:14.7
doi:10.1038/s41467-020-15505-4
Angela Tomasovic #, Theresa Brand #, Constanze Schanbacher #, Sofia Kramer, Martin W Hümmert, Patricio Godoy, Wolfgang Schmidt-Heck, Peter Nordbeck, Jonas Ludwig, Susanne Homann, Armin Wiegering, Timur Shaykhutdinov, Christoph Kratz, Ruth Knüchel, Hans-Konrad Müller-Hermelink, Andreas Rosenwald, Nor
信号转导
IHC
MAPK/ERK
Goat
IgG Fc