日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Infliximab reduces peripheral inflammation, neuroinflammation, and extracellular GABA in the cerebellum and improves learning and motor coordination in rats with hepatic encephalopathy

英夫利昔单抗可减少肝性脑病大鼠的外周炎症、神经炎症和小脑细胞外 GABA,并改善学习和运动协调能力

Sherry Dadsetan, Tiziano Balzano, Jerónimo Forteza, Ana Agusti, Andrea Cabrera-Pastor, Lucas Taoro-Gonzalez, Vicente Hernandez-Rabaza, Belen Gomez-Gimenez, Nisrin ElMlili, Marta Llansola, Vicente Felipo

Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia

神经炎症通过增加 GAT-3 膜表达来增加 GABA 能张力并损害高氨血症中的认知和运动功能。萝卜硫素通过促进小胶质细胞的 M2 极化来逆转这一现象

Vicente Hernandez-Rabaza, Andrea Cabrera-Pastor, Lucas Taoro-Gonzalez, Alba Gonzalez-Usano, Ana Agusti, Tiziano Balzano, Marta Llansola, Vicente Felipo

Reducing Peripheral Inflammation with Infliximab Reduces Neuroinflammation and Improves Cognition in Rats with Hepatic Encephalopathy

英夫利昔单抗可减轻外周炎症,从而减轻肝性脑病大鼠的神经炎症并改善其认知功能。

Dadsetan, Sherry; Balzano, Tiziano; Forteza, Jerónimo; Cabrera-Pastor, Andrea; Taoro-Gonzalez, Lucas; Hernandez-Rabaza, Vicente; Gil-Perotín, Sara; Cubas-Núñez, Laura; García-Verdugo, José-Manuel; Agusti, Ana; Llansola, Marta; Felipo, Vicente

Sildenafil reduces neuroinflammation and restores spatial learning in rats with hepatic encephalopathy: underlying mechanisms

西地那非可减轻肝性脑病大鼠的神经炎症并恢复其空间学习能力:潜在机制

Hernandez-Rabaza, Vicente; Agusti, Ana; Cabrera-Pastor, Andrea; Fustero, Santos; Delgado, Oscar; Taoro-Gonzalez, Lucas; Montoliu, Carmina; Llansola, Marta; Felipo, Vicente

The expression levels of prolyl oligopeptidase responds not only to neuroinflammation but also to systemic inflammation upon liver failure in rat models and cirrhotic patients

在鼠模型和肝硬化患者中,脯氨酰寡肽酶的表达水平不仅对神经炎症有反应,而且对肝衰竭时的全身炎症也有反应。

Tenorio-Laranga, Jofre; Montoliu, Carmina; Urios, Amparo; Hernandez-Rabaza, Vicente; Ahabrach, Hanan; García-Horsman, J Arturo; Felipo, Vicente

Rats with minimal hepatic encephalopathy due to portacaval shunt show differential increase of translocator protein (18 kDa) binding in different brain areas, which is not affected by chronic MAP-kinase p38 inhibition

因门腔静脉分流术导致轻微肝性脑病的大鼠,不同脑区转运蛋白 (18 kDa) 结合量有差异性增加,而慢性 MAP-激酶 p38 抑制不会对此产生影响

Ana Agusti, Jennifer L Dziedzic, Vicente Hernandez-Rabaza, Tomas R Guilarte, Vicente Felipo