日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

High-throughput biochemical phenotyping of SHP2 variants reveals the molecular basis of diseases and allosteric drug inhibition

SHP2 变体的高通量生化表型分析揭示了疾病的分子基础和变构药物抑制作用

Lee, Albert A; Mokhtari, Daniel A; Egan, Emily D; Blacklow, Stephen C; Herschlag, Daniel; Fordyce, Polly M

Proteolytic activation of diverse antiviral defense modules in prokaryotes

原核生物中多种抗病毒防御模块的蛋白水解激活

Evans, Simone A; Zhang, Jianxiu; Lam, Yannie; Wang, Katherine; Lin, Yu Tin; Herschlag, Daniel; Feng, Liang; Gao, Alex

Exploring the energetic and conformational properties of the sequence space connecting naturally occurring RNA tetraloop receptor motifs

探索连接天然存在的RNA四环受体基序的序列空间的能量和构象特性

Shin, John H; Cuevas, Lena M; Roy, Rohit; Bonilla, Steve L; Al-Hashimi, Hashim; Greenleaf, William J; Herschlag, Daniel

Decoupling of catalysis and transition state analog binding from mutations throughout a phosphatase revealed by high-throughput enzymology

高通量酶学揭示磷酸酶中催化作用和过渡态类似物结合的解耦与突变的关系

Markin, Craig J; Mokhtari, Daniel A; Du, Siyuan; Doukov, Tzanko; Sunden, Fanny; Cook, Jordan A; Fordyce, Polly M; Herschlag, Daniel

Obtaining anomalous and ensemble information from protein crystals from 220†K up to physiological temperatures.

从 220 K 到生理温度下的蛋白质晶体中获取异常和整体信息

Doukov Tzanko, Herschlag Daniel, Yabukarski Filip

Refinement of multiconformer ensemble models from multi-temperature X-ray diffraction data.

利用多温度X射线衍射数据改进多构象体集合模型

Du Siyuan, Wankowicz Stephanie A, Yabukarski Filip, Doukov Tzanko, Herschlag Daniel, Fraser James S

Refinement of Multiconformer Ensemble Models from Multi-temperature X-ray Diffraction Data.

利用多温度X射线衍射数据改进多构象体集合模型

Du Siyuan, Wankowicz Stephanie A, Yabukarski Filip, Doukov Tzanko, Herschlag Daniel, Fraser James S

Direct Measurement of Interhelical DNA Repulsion and Attraction by Quantitative Cross-Linking

通过定量交联直接测量DNA螺旋间的排斥和吸引作用

Hamilton, Ian; Gebala, Magdalena; Herschlag, Daniel; Russell, Rick

Ensemble-function relationships to dissect mechanisms of enzyme catalysis

利用整体功能关系剖析酶催化机制

Yabukarski, Filip; Doukov, Tzanko; Pinney, Margaux M; Biel, Justin T; Fraser, James S; Herschlag, Daniel

Evaluating the impact of X-ray damage on conformational heterogeneity in room-temperature (277†K) and cryo-cooled protein crystals.

评估 X 射线损伤对室温 (277 K) 和低温冷却蛋白质晶体构象异质性的影响

Yabukarski Filip, Doukov Tzanko, Mokhtari Daniel A, Du Siyuan, Herschlag Daniel