Silencing FLI or targeting CD13/ANPEP lead to dephosphorylation of EPHA2, a mediator of BRAF inhibitor resistance, and induce growth arrest or apoptosis in melanoma cells
沉默 FLI 或靶向 CD13/ANPEP 会导致 EPHA2(BRAF 抑制剂耐药性的介质)去磷酸化,并诱导黑色素瘤细胞生长停滞或凋亡
期刊:Cell Death & Disease
影响因子:8.1
doi:10.1038/cddis.2017.406
Alireza Azimi, Rainer Tuominen, Fernanda Costa Svedman, Stefano Caramuta, Maria Pernemalm, Marianne Frostvik Stolt, Lena Kanter, Pedram Kharaziha, Janne Lehtiö, Carolina Hertzman Johansson, Veronica Höiom, Johan Hansson, Suzanne Egyhazi Brage
信号转导
肿瘤
表观遗传
黑色素瘤
肿瘤细胞
Apoptosis