日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
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2025
2026
影响因子:
–

In vivo lentiviral vector gene therapy to cure hereditary tyrosinemia type 1 and prevent development of precancerous and cancerous lesions

利用体内慢病毒载体基因疗法治愈1型遗传性酪氨酸血症并预防癌前病变和癌变的发展

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-022-32576-7
Nicolas, Clara T; VanLith, Caitlin J; Hickey, Raymond D; Du, Zeji; Hillin, Lori G; Guthman, Rebekah M; Cao, William J; Haugo, Benjamin; Lillegard, Annika; Roy, Diya; Bhagwate, Aditya; O'Brien, Daniel; Kocher, Jean-Pierre; Kaiser, Robert A; Russell, Stephen J; Lillegard, Joseph B
微生物学
肿瘤
肿瘤免疫
发表日期：2022
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Autologous Gene and Cell Therapy Provides Safe and Long-Term Curative Therapy in A Large Pig Model of Hereditary Tyrosinemia Type 1

自体基因和细胞疗法在大型猪遗传性酪氨酸血症1型模型中提供安全且长期的治愈性治疗

期刊:Cell Transplantation
影响因子:3.2
doi:10.1177/0963689718814188
Hickey, Raymond D; Nicolas, Clara T; Allen, Kari; Mao, Shennen; Elgilani, Faysal; Glorioso, Jaime; Amiot, Bruce; VanLith, Caitlin; Guthman, Rebekah; Du, Zeji; Chen, Harvey; Harding, Cary O; Kaiser, Robert A; Nyberg, Scott L; Lillegard, Joseph B
细胞生物学
发表日期：2019
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Curative Ex Vivo Hepatocyte-Directed Gene Editing in a Mouse Model of Hereditary Tyrosinemia Type 1

在1型遗传性酪氨酸血症小鼠模型中，体外肝细胞定向基因编辑的治愈性治疗

期刊:Human Gene Therapy
影响因子:4
doi:10.1089/hum.2017.252
VanLith, Caitlin; Guthman, Rebekah; Nicolas, Clara T; Allen, Kari; Du, Zeji; Joo, Dong Jin; Nyberg, Scott L; Lillegard, Joseph B; Hickey, Raymond D
细胞生物学
Mouse
发表日期：2018
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Hepatocyte spheroids as an alternative to single cells for transplantation after ex vivo gene therapy in mice and pig models

在小鼠和猪模型中，肝细胞球体可作为单细胞移植的替代方案，用于体外基因治疗后进行移植。

期刊:Surgery
影响因子:2.7
doi:10.1016/j.surg.2018.04.012
Nicolas, Clara T; Hickey, Raymond D; Allen, Kari L; Du, Zeji; Guthman, Rebekah M; Kaiser, Robert A; Amiot, Bruce; Bansal, Aditya; Pandey, Mukesh K; Suksanpaisan, Lukkana; DeGrado, Timothy R; Nyberg, Scott L; Lillegard, Joseph B
单细胞
基因治疗
细胞生物学
发表日期：2018
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Lentiviral Vector-mediated Gene Therapy of Hepatocytes Ex Vivo for Autologous Transplantation in Swine.

利用慢病毒载体介导的体外肝细胞基因治疗进行猪自体移植

期刊:Jove-Journal of Visualized Experiments
影响因子:1
doi:10.3791/58399
Kaiser Robert A, Mao Shennen A, Glorioso Jaime, Amiot Bruce, Nicolas Clara T, Allen Kari L, Du Zeji, VanLith Caitlin J, Hickey Raymond D, Nyberg Scott L, Lillegard Joseph B
细胞生物学
Viral
细胞基因治疗
发表日期：2018
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Chronic Phenotype Characterization of a Large-Animal Model of Hereditary Tyrosinemia Type 1

遗传性酪氨酸血症1型大型动物模型的慢性表型特征

期刊:American Journal of Pathology
影响因子:3.6
doi:10.1016/j.ajpath.2016.09.013
Elgilani, Faysal; Mao, Shennen A; Glorioso, Jaime M; Yin, Meng; Iankov, Ianko D; Singh, Anisha; Amiot, Bruce; Rinaldo, Piero; Marler, Ronald J; Ehman, Richard L; Grompe, Markus; Lillegard, Joseph B; Hickey, Raymond D; Nyberg, Scott L
发表日期：2017
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Concise Review: Liver Regenerative Medicine: From Hepatocyte Transplantation to Bioartificial Livers and Bioengineered Grafts

简明综述：肝脏再生医学：从肝细胞移植到生物人工肝脏和生物工程移植物

期刊:Stem Cells
影响因子:3.6
doi:10.1002/stem.2500
Nicolas, Clara T; Hickey, Raymond D; Chen, Harvey S; Mao, Shennen A; Lopera Higuita, Manuela; Wang, Yujia; Nyberg, Scott L
细胞生物学
发育与干细胞
发表日期：2017
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Silent Tyrosinemia Type I Without Elevated Tyrosine or Succinylacetone Associated with Liver Cirrhosis and Hepatocellular Carcinoma

I型无症状酪氨酸血症，无酪氨酸或琥珀酰丙酮水平升高，伴有肝硬化和肝细胞癌

期刊:Human Mutation
影响因子:3.7
doi:10.1002/humu.23047
Blackburn, Patrick R; Hickey, Raymond D; Nace, Rebecca A; Giama, Nasra H; Kraft, Daniel L; Bordner, Andrew J; Chaiteerakij, Roongruedee; McCormick, Jennifer B; Radulovic, Maja; Graham, Rondell P; Torbenson, Michael S; Tortorelli, Silvia; Scott, C Ronald; Lindor, Noralane M; Milliner, Dawn S; Oglesbee, Devin; Al-Qabandi, Wafa'a; Grompe, Markus; Gavrilov, Dimitar K; El-Youssef, Mounif; Clark, Karl J; Atwal, Paldeep S; Roberts, Lewis R; Klee, Eric W; Ekker, Stephen C
细胞生物学
肿瘤
肝硬化
肿瘤免疫
发表日期：2016
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Pivotal preclinical trial of the spheroid reservoir bioartificial liver

球状体储库生物人工肝的关键性临床前试验

期刊:Journal of Hepatology
影响因子:33
doi:10.1016/j.jhep.2015.03.021
Glorioso, Jaime M; Mao, Shennen A; Rodysill, Brian; Mounajjed, Taufic; Kremers, Walter K; Elgilani, Faysal; Hickey, Raymond D; Haugaa, Hakon; Rose, Christopher F; Amiot, Bruce; Nyberg, Scott L
发表日期：2015
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Efficient production of Fah-null heterozygote pigs by chimeric adeno-associated virus-mediated gene knockout and somatic cell nuclear transfer

利用嵌合腺相关病毒介导的基因敲除和体细胞核移植高效生产Fah基因缺失杂合子猪

期刊:Hepatology
影响因子:15.8
doi:10.1002/hep.24490
Hickey, Raymond D; Lillegard, Joseph B; Fisher, James E; McKenzie, Travis J; Hofherr, Sean E; Finegold, Milton J; Nyberg, Scott L; Grompe, Markus
微生物学
细胞生物学
发表日期：2011
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