日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Integrated Population Pharmacokinetic, Pharmacodynamic, and Safety Analyses to Inform Dosage Selection in the Clinical Development of the ATR Inhibitor Tuvusertib

综合群体药代动力学、药效学和安全性分析，为ATR抑制剂Tuvusertib的临床开发中的剂量选择提供信息

期刊:Clinical Pharmacology & Therapeutics
影响因子:5.5
doi:10.1002/cpt.70029
Mukker, Jatinder Kaur; Diderichsen, Paul Matthias; Hellmann, Farina; Yap, Timothy A; Plummer, Ruth; Tolcher, Anthony W; de Bono, Johann S; Gounaris, Ioannis; Szucs, Zoltan; Zimmermann, Astrid; Kareva, Irina; Bolleddula, Jayaprakasam; Seithel-Keuth, Annick; Locatelli, Giuseppe; Enderlin, Marta; Hicking, Christine; Zutshi, Anup; Gao, Wei; Strotmann, Rainer; Benincosa, Lisa; Venkatakrishnan, Karthik
ATR
发表日期：2026
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A First-in-Human Study of ATM Inhibitor Lartesertib as Monotherapy in Patients with Advanced Solid Tumors

一项针对晚期实体瘤患者的ATM抑制剂Lartesertib单药治疗的首次人体研究

期刊:Clinical Cancer Research
影响因子:10.2
doi:10.1158/1078-0432.CCR-25-1648
Siu, Lillian L; Yap, Timothy A; Genta, Sofia; Pennock, Gregory; Hicking, Christine; Vagge, Deepthi S; Mukker, Jatinder Kaur; Locatelli, Giuseppe; Tolcher, Anthony W
ATM
Human
发表日期：2025
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First-in-Human Study of the Ataxia Telangiectasia and Rad3-Related (ATR) Inhibitor Tuvusertib (M1774) as Monotherapy in Patients with Solid Tumors

首次人体研究：毛细血管扩张性共济失调和Rad3相关（ATR）抑制剂Tuvusertib（M1774）作为单药疗法治疗实体瘤患者

期刊:Clinical Cancer Research
影响因子:10.2
doi:10.1158/1078-0432.CCR-23-2409
Yap, Timothy A; Tolcher, Anthony W; Plummer, Ruth; Mukker, Jatinder Kaur; Enderlin, Marta; Hicking, Christine; Grombacher, Thomas; Locatelli, Giuseppe; Szucs, Zoltan; Gounaris, Ioannis; de Bono, Johann S
ATR
Human
发表日期：2024
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Translational imaging of TSPO reveals pronounced innate inflammation in human and murine CD8 T cell-mediated limbic encephalitis

TSPO 的转化成像揭示了人类和鼠 CD8 T 细胞介导的边缘叶脑炎中明显的先天性炎症

期刊:Science Advances
影响因子:11.7
doi:10.1126/sciadv.abq7595
Marco Gallus, Wolfgang Roll, Andre Dik, Cristina Barca, Bastian Zinnhardt, Gordon Hicking, Christoph Mueller, Venu Narayanan Naik, Max Anstötz, Julia Krämer, Leoni Rolfes, Lydia Wachsmuth, Julika Pitsch, Karen M J van Loo, Saskia Räuber, Hideho Okada, Catriona Wimberley, Christine Strippel, Kristin
信号转导
免疫
神经
脑炎
T细胞
ELISA
WB
Translational Control
Donkey
IgG
发表日期：2023
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Identification of HMGA2 as a predictive biomarker of response to bintrafusp alfa in a phase 1 trial in patients with advanced triple-negative breast cancer

在针对晚期三阴性乳腺癌患者的 I 期临床试验中，HMGA2 被鉴定为 bintrafusp alfa 疗效的预测性生物标志物

期刊:Frontiers in Oncology
影响因子:3.3
doi:10.3389/fonc.2022.981940
Spira, Alexander; Awada, Ahmad; Isambert, Nicolas; Lorente, David; Penel, Nicolas; Zhang, Yue; Ojalvo, Laureen S; Hicking, Christine; Rolfe, P Alexander; Ihling, Christian; Dussault, Isabelle; Locke, George; Borel, Christian
肿瘤
肿瘤免疫
乳腺癌
发表日期：2022
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CD8+ T-Lymphocyte-Driven Limbic Encephalitis Results in Temporal Lobe Epilepsy

CD8+ T 淋巴细胞驱动的边缘脑炎导致颞叶癫痫

期刊:Annals of Neurology
影响因子:8.1
doi:10.1002/ana.26000
Julika Pitsch #, Karen M J van Loo #, Marco Gallus #, Andre Dik #, Delara Kamalizade, Ann-Kathrin Baumgart, Vadym Gnatkovsky, Johannes Alexander Müller, Thoralf Opitz, Gordon Hicking, Venu Narayanan Naik, Lydia Wachsmuth, Cornelius Faber, Rainer Surges, Christian Kurts, Susanne Schoch, Nico Melzer #
免疫
神经
细胞生物学
癫痫
脑炎
T细胞
发表日期：2021
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Integration of Novel Sensors and Machine Learning for Predictive Maintenance in Medium Voltage Switchgear to Enable the Energy and Mobility Revolutions

将新型传感器和机器学习技术集成到中压开关设备预测性维护中，以推动能源和交通革命

期刊:Sensors
影响因子:3.5
doi:10.3390/s20072099
Hoffmann, Martin W; Wildermuth, Stephan; Gitzel, Ralf; Boyaci, Aydin; Gebhardt, Jörg; Kaul, Holger; Amihai, Ido; Forg, Bodo; Suriyah, Michael; Leibfried, Thomas; Stich, Volker; Hicking, Jan; Bremer, Martin; Kaminski, Lars; Beverungen, Daniel; Zur Heiden, Philipp; Tornede, Tanja
发表日期：2020
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Efficacy of Cladribine Tablets in high disease activity subgroups of patients with relapsing multiple sclerosis: A post hoc analysis of the CLARITY study

克拉屈滨片在复发型多发性硬化症高疾病活动度亚组患者中的疗效：CLARITY 研究的事后分析

期刊:Multiple Sclerosis Journal
影响因子:5
doi:10.1177/1352458518771875
Giovannoni, Gavin; Soelberg Sorensen, Per; Cook, Stuart; Rammohan, Kottil W; Rieckmann, Peter; Comi, Giancarlo; Dangond, Fernando; Hicking, Christine; Vermersch, Patrick
神经科学
多发性硬化症
发表日期：2019
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Cladribine tablets added to IFN-β in active relapsing MS: The ONWARD study

在复发型多发性硬化症活动期患者中，克拉屈滨片剂联合干扰素β治疗：ONWARD 研究

期刊:Neurology-Neuroimmunology & Neuroinflammation
影响因子:7.5
doi:10.1212/NXI.0000000000000477
Montalban, Xavier; Leist, Thomas P; Cohen, Bruce A; Moses, Harold; Campbell, Jackie; Hicking, Christine; Dangond, Fernando
神经科学
多发性硬化症
发表日期：2018
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Cilengitide in newly diagnosed glioblastoma: biomarker expression and outcome

西伦吉肽治疗新诊断的胶质母细胞瘤：生物标志物表达和疗效

期刊:Oncotarget
影响因子:
doi:10.18632/oncotarget.7588
Weller, Michael; Nabors, Louis Burt; Gorlia, Thierry; Leske, Henning; Rushing, Elisabeth; Bady, Pierre; Hicking, Christine; Perry, James; Hong, Yong-Kil; Roth, Patrick; Wick, Wolfgang; Goodman, Simon L; Hegi, Monika E; Picard, Martin; Moch, Holger; Straub, Josef; Stupp, Roger
细胞生物学
发表日期：2016
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