日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Matching heterogeneous cohorts by projected principal components reveals two novel Alzheimer's disease-associated genes in the Hispanic population

通过预测主成分匹配异质性队列,揭示了西班牙裔人群中两个新的阿尔茨海默病相关基因

Willett, Julian Daniel Sunday; Waqas, Mohamad; Naumenko, Serhiy; Mullin, Kristina; Hecker, Julian; Bertram, Lars; Lange, Christoph; Vlachos, Ioannis; Hide, Winston; Tanzi, Rudolph E; Prokopenko, Dmitry

Aging-related Transcriptomic Changes with Spatial Resolution in the Human Prefrontal Cortex.

人类前额叶皮层中与衰老相关的转录组变化及其空间分辨率。

Rai Anupama, Iatrou Artemis, Arzeta Irais Valenzuela, Bartlett Alexandra L, Banahan Jane, Desai Vedant, Pantano Lorena, Castanho Isabel, Yeganeh Pourya Naderi, Ploumakis Athanasios, Wang Shuoshuo, de Amaral Antonella Arruda, Kalavros Nikolaos, Nagalakshmi Sheethal Umesh, Tsvetkov Peter, Berretta Sabina, Solomon Isaac H, Hide Winston, Vlachos Ioannis S, Slack Frank J, Ozdemir Recep, Sui Shannan Ho, Daskalakis Nikolaos P, Mavrikaki Maria

Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheimer's disease.

兴奋性和抑制性神经元对阿尔茨海默病的分子适应性特征。

Castanho Isabel, Naderi Yeganeh Pourya, Boix Carles A, Morgan Sarah L, Mathys Hansruedi, Prokopenko Dmitry, White Bartholomew, Soto Larisa M, Pegoraro Giulia, Shah Saloni, Ploumakis Athanasios, Kalavros Nikolas, Bennett David A, Lange Christoph, Kim Doo Yeon, Bertram Lars, Tsai Li-Huei, Kellis Manolis, Tanzi Rudolph E, Hide Winston

Integrative pathway analysis across humans and 3D cellular models identifies the p38 MAPK-MK2 axis as a therapeutic target for Alzheimer's disease.

对人类和 3D 细胞模型进行整合通路分析,确定 p38 MAPK-MK2 轴是阿尔茨海默病的一种治疗靶点

Naderi Yeganeh Pourya, Kwak Sang Su, Jorfi Mehdi, Koler Katjuša, Kalatturu Thejesh, von Maydell Djuna, Liu Zhiqing, Guo Kevin, Choi Younjung, Park Joseph, Abarca Nelson, Bakiasi Grisilda, Cetinbas Murat, Sadreyev Ruslan, Griciuc Ana, Quinti Luisa, Choi Se Hoon, Xia Weiming, Tanzi Rudolph E, Hide Winston, Kim Doo Yeon

A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients.

COVID-19 肝脏的单核和空间转录组图谱揭示了患者的拓扑、功能和再生器官破坏

Pita-Juarez Yered, Karagkouni Dimitra, Kalavros Nikolaos, Melms Johannes C, Niezen Sebastian, Delorey Toni M, Essene Adam L, Brook Olga R, Pant Deepti, Skelton-Badlani Disha, Naderi Pourya, Huang Pinzhu, Pan Liuliu, Hether Tyler, Andrews Tallulah S, Ziegler Carly G K, Reeves Jason, Myloserdnyy Andriy, Chen Rachel, Nam Andy, Phelan Stefan, Liang Yan, Gregory Mark, He Shanshan, Patrick Michael, Rane Tushar, Wardhani Aster, Amin Amit Dipak, Biermann Jana, Hibshoosh Hanina, Veregge Molly, Kramer Zachary, Jacobs Christopher, Yalcin Yusuf, Phillips Devan, Slyper Michal, Subramanian Ayshwarya, Ashenberg Orr, Bloom-Ackermann Zohar, Tran Victoria M, Gomez James, Sturm Alexander, Zhang Shuting, Fleming Stephen J, Warren Sarah, Beechem Joseph, Hung Deborah, Babadi Mehrtash, Padera Robert F Jr, MacParland Sonya A, Bader Gary D, Imad Nasser, Solomon Isaac H, Miller Eric, Riedel Stefan, Porter Caroline B M, Villani Alexandra-Chloé, Tsai Linus T-Y, Hide Winston, Szabo Gyongyi, Hecht Jonathan, Rozenblatt-Rosen Orit, Shalek Alex K, Izar Benjamin, Regev Aviv, Popov Yury V, Jiang Z Gordon, Vlachos Ioannis S

A PKCη missense mutation enhances Golgi-localized signaling and is associated with recessively inherited familial Alzheimer's disease.

PKCη错义突变增强了高尔基体定位的信号传导,并且与隐性遗传的家族性阿尔茨海默病有关

Gauron Maria Celeste, Prokopenko Dmitry, Lee Sanghun, Wolfe Sarah A, Hecker Julian, Willett Julian, Waqas Mohammad, Lordén Gema, Yang Yimin, Mayfield Joshua E, Castanho Isabel, Mullin Kristina, Morgan Sarah, Hahn Georg, Demeo Dawn L, Hide Winston, Bertram Lars, Lange Christoph, Newton Alexandra C, Tanzi Rudolph E

Matching Heterogeneous Cohorts by Projected Principal Components Reveals Two Novel Alzheimer's Disease-Associated Genes in the Hispanic Population

通过预测主成分匹配异质队列,揭示了西班牙裔人群中两个新的阿尔茨海默病相关基因

Willett, Julian Daniel Sunday; Waqas, Mohamad; Naumenko, Serhiy; Mullin, Kristina; Hecker, Julian; Bertram, Lars; Lange, Christoph; Vlachos, Ioannis; Hide, Winston; Tanzi, Rudolph E; Prokopenko, Dmitry

Context-dependent regulatory variants in Alzheimer's disease.

阿尔茨海默病中与环境相关的调控变异

Chen Ziheng, Liu Yaxuan, Brown Ashley R, Sestili Heather H, Ramamurthy Easwaran, Xiong Xushen, Prokopenko Dmitry, Phan BaDoi N, Gadey Lahari, Hu Peinan, Tsai Li-Huei, Bertram Lars, Hide Winston, Tanzi Rudolph E, Kellis Manolis, Pfenning Andreas R

Protein kinase C eta enhances Golgi-localized signaling and is associated with Alzheimer's disease using a recessive mode of inheritance.

蛋白激酶 C eta 可增强高尔基体定位的信号传导,并以隐性遗传方式与阿尔茨海默病相关

Gauron Maria Celeste, Prokopenko Dmitry, Lee Sanghun, Wolfe Sarah A, Hecker Julian, Willett Julian, Waqas Mohammad, Lordén Gema, Yang Yimin, Mayfield Joshua E, Castanho Isabel, Mullin Kristina, Morgan Sarah, Hahn Georg, Demeo Dawn L, Hide Winston, Bertram Lars, Lange Christoph, Newton Alexandra C, Tanzi Rudolph E

Prediction of disease-free survival for precision medicine using cooperative learning on multi-omic data

利用多组学数据协同学习预测精准医疗中的无病生存期

Hahn, Georg; Prokopenko, Dmitry; Hecker, Julian; Lutz, Sharon M; Mullin, Kristina; Sejour, Leinal; Hide, Winston; Vlachos, Ioannis; DeSantis, Stacia; Tanzi, Rudolph E; Lange, Christoph