日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Antisense Dipeptide Repeat Proteins Drive Widescale Purine Metabolism Aberration in C9orf72 Amyotrophic Lateral Sclerosis via ADA

反义二肽重复蛋白通过ADA驱动C9orf72肌萎缩侧索硬化症中广泛的嘌呤代谢异常。

Benjamin Hall,Lydia Castelli,Adrian Higginbottom,Jingxuan He,Ling-Nan Zou,Heather Walker,Miriam Yagüe-Capilla,Kari E Wong,David J Burrows,Jonathan George,Keaton Hamer,Jenny M Tanner,Ergita Kyrgiou-Balli,Rees Ross,Herbie Garland,Erin Tonkiss,Rachel George,Christopher P Webster,Emma F Smith,Hannah O Timmons,Jess Allsop,Nikolas Stefanidis,Billie D Ward,Ya-Hui Lin,J Robin Highley,Mimoun Azzouz,Ryan J H West,Sean G Rudd,Kurt J De Vos,Pamela J Shaw,Guillaume M Hautbergue,Scott P Allen

Indole-3-acetic acid production is rare among gut bacteria and reflects OFOR-driven amino acid oxidation in acetogens

吲哚-3-乙酸的产生在肠道细菌中较为罕见,它反映了产乙酸菌中OFOR驱动的氨基酸氧化作用。

DeFeo, Mary E; Liu, Yuanyuan; Zhou, Zhiwei; Higginbottom, Steven K; Dodd, Dylan

Histone methyltransferase PRDM9 promotes survival of drug-tolerant persister cells in glioblastoma.

组蛋白甲基转移酶PRDM9促进胶质母细胞瘤中耐药持续细胞的存活。

Joun George L, Kempe Emma G, Chen Brianna, Sterling Jayden R, Abbassi Ramzi H, Friess Dana, Singleton Matthew, Choudhury Chandra, Marian Oana C, du Preez W Daniel, Recasens Ariadna, Clark Teleri, Du Tian Y, Low Jason K K, Kim Hani, Yang Pengyi, Khor Jasmine, Hoque Monira, Indurthi Dinesh C, Kuchibhotla Mani, Palanisamy Ranjith, Jorgensen William T, Montgomery Andrew P, Baker Jennifer R, Higginbottom Sarah L, Tomaskovic-Crook Eva, Crook Jeremy M, Loo Lipin, Day Bryan W, Neely G Gregory, Guccione Ernesto, Johns Terrance G, Kassiou Michael, Feng Yuchen, Harris Lachlan, Don Anthony S, Munoz Lenka

A bacterial artificial chromosome mouse model of amyotrophic lateral sclerosis manifests 'space cadet syndrome' on two FVB backgrounds

肌萎缩侧索硬化症的细菌人工染色体小鼠模型在两种 FVB 背景下表现出“太空学员综合征”

Sophie E Badger, Ian Coldicott, Ergita Kyrgiou-Balli, Adrian Higginbottom, Chloé Moutin, Kamallia Mohd Imran, John C Day, Johnathan Cooper-Knock, Richard J Mead, James J P Alix

Stakeholder Involvement in the Development of a New Proactive Clinical Review of Patients Prescribed Opioid Medicines Long-Term for Persistent Pain in Primary Care

利益相关者参与制定一项针对长期服用阿片类药物治疗持续性疼痛的初级保健患者的主动式临床审查新方案

Harrisson, Sarah A; Jinks, Clare; Cornwall, Nicola; Woodcock, Charlotte; Dikomitis, Lisa; Helliwell, Toby; Higginbottom, Adele; Lefroy, Janet; Knaggs, Roger; Pincus, Tamar; Santar, Miriam; Sillitto, Claire; Webb, Matthew; White, Simon; Mallen, Christian D; Ashworth, Julie

Establishing a Public Involvement Network for Chronic Pain Research in the United Kingdom: Lessons Learned

在英国建立慢性疼痛研究公众参与网络:经验教训

Grieve, Sharon; Harrison, Rosie; Chew-Graham, Carolyn; Taverner, Ian; Lloyd, Joanne; Shivji, Noureen; Readman, Ellen; Higginbottom, Adele; Wilkinson, Colin; Austin, Lisa; Keogh, Edmund; McCabe, Candida

Systematic review of Apgar scores & cyanosis in Black, Asian, and ethnic minority infants

对黑人、亚裔和少数族裔婴儿的Apgar评分和紫绀情况进行系统性回顾

Fair, Frankie J; Furness, Amy; Higginbottom, Gina; Oddie, Sam J; Soltani, Hora

RuvBL1/2 reduce toxic dipeptide repeat protein burden in multiple models of C9orf72-ALS/FTD.

RuvBL1/2 可降低多种 C9orf72-ALS/FTD 模型中的毒性二肽重复蛋白负荷

Webster Christopher P, Hall Bradley, Crossley Olivia M, Dauletalina Dana, King Marianne, Lin Ya-Hui, Castelli Lydia M, Yang Zih-Liang, Coldicott Ian, Kyrgiou-Balli Ergita, Higginbottom Adrian, Ferraiuolo Laura, De Vos Kurt J, Hautbergue Guillaume M, Shaw Pamela J, West Ryan Jh, Azzouz Mimoun

Gut microbiota gate host exposure to cholinesterase inhibitors from dietary Solanums

肠道菌群控制宿主对膳食茄属植物中胆碱酯酶抑制剂的暴露

Liou, Catherine S; Louwies, Tijs; Iakiviak, Mikhail; Rajniak, Jakub; Murugkar, Pallavi P; Higginbottom, Steven K; Weakley, Allison; Meng, Xiandong; Htet, Phyu; Cabrera, Ashley V; Jasper, Marissa; Dimas, Alex; Schulman, E A; Fischbach, Michael A; Kashyap, Purna C; Sattely, Elizabeth S

A gut pathobiont regulates circulating glycine and host metabolism in a twin study comparing vegan and omnivorous diets

一项比较纯素食和杂食饮食的双胞胎研究表明,肠道致病菌能够调节循环甘氨酸和宿主代谢。

Carter, Matthew M; Zeng, Xianfeng; Ward, Catherine P; Landry, Matthew; Perelman, Dalia; Hennings, Tayler; Meng, Xiandong; Weakley, Allison M; Cabrera, Ashley V; Robinson, Jennifer L; Nguyen, Tran; Higginbottom, Steven; Maecker, Holden T; Sonnenburg, Erica D; Fischbach, Michael A; Gardner, Christopher D; Sonnenburg, Justin L