日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

RuvBL1/2 reduce toxic dipeptide repeat protein burden in multiple models of C9orf72-ALS/FTD.

RuvBL1/2 可降低多种 C9orf72-ALS/FTD 模型中的毒性二肽重复蛋白负荷

Webster Christopher P, Hall Bradley, Crossley Olivia M, Dauletalina Dana, King Marianne, Lin Ya-Hui, Castelli Lydia M, Yang Zih-Liang, Coldicott Ian, Kyrgiou-Balli Ergita, Higginbottom Adrian, Ferraiuolo Laura, De Vos Kurt J, Hautbergue Guillaume M, Shaw Pamela J, West Ryan Jh, Azzouz Mimoun

Targeted Genetic Screen in Amyotrophic Lateral Sclerosis Reveals Novel Genetic Variants with Synergistic Effect on Clinical Phenotype

肌萎缩侧索硬化症靶向基因筛查揭示了对临床表型具有协同效应的新型基因变异

Cooper-Knock, Johnathan; Robins, Henry; Niedermoser, Isabell; Wyles, Matthew; Heath, Paul R; Higginbottom, Adrian; Walsh, Theresa; Kazoka, Mbombe; Ince, Paul G; Hautbergue, Guillaume M; McDermott, Christopher J; Kirby, Janine; Shaw, Pamela J

A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort

在阿尔茨海默病神经病理学的早期阶段即可检测到神经元DNA损伤反应,并且该反应与医学研究委员会认知功能与衰老研究老龄化大脑队列中的认知障碍相关。

Simpson, Julie E; Ince, Paul G; Matthews, Fiona E; Shaw, Pamela J; Heath, Paul R; Brayne, Carol; Garwood, Claire; Higginbottom, Adrian; Wharton, Stephen B

An in vitro screening cascade to identify neuroprotective antioxidants in ALS

体外筛选级联法用于鉴定肌萎缩侧索硬化症(ALS)中的神经保护性抗氧化剂

Barber, Siân C; Higginbottom, Adrian; Mead, Richard J; Barber, Stuart; Shaw, Pamela J

The role of the N-terminal domain of the complement fragment receptor C5L2 in ligand binding

补体片段受体C5L2的N端结构域在配体结合中的作用

Scola, Anne-Marie; Higginbottom, Adrian; Partridge, Lynda J; Reid, Robert C; Woodruff, Trent; Taylor, Stephen M; Fairlie, David P; Monk, Peter N

Recombinant extracellular domains of tetraspanin proteins are potent inhibitors of the infection of macrophages by human immunodeficiency virus type 1

重组四跨膜蛋白胞外结构域是人类免疫缺陷病毒1型感染巨噬细胞的有效抑制剂

Ho, Siu-Hong; Martin, Francine; Higginbottom, Adrian; Partridge, Lynda J; Parthasarathy, Varadarajan; Moseley, Gregory W; Lopez, Peter; Cheng-Mayer, Cecilia; Monk, Peter N