Higgins Craig E相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

Targeted Interference with USF2 Binding to the SERPINE1 Proximal Promoter E-Box in Dual Mutant p53(R282Q,H179Y) Human Keratinocytes Inhibits Serum-/TGF-β1-Induced SERPINE1 Expression and Stimulates Epithelial Cell Proliferation

在双突变体p53(R282Q,H179Y)人角质形成细胞中，靶向干扰USF2与SERPINE1近端启动子E-box的结合可抑制血清/TGF-β1诱导的SERPINE1表达并刺激上皮细胞增殖。

期刊:Biomedicines

影响因子:3.9

doi:10.3390/biomedicines14030726

Higgins, Stephen P; Czekay, Ralf-Peter; Higgins, Craig E; Higgins, Paul J

细胞生物学

发表日期：2026

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SERPINE1: Role in Cholangiocarcinoma Progression and a Therapeutic Target in the Desmoplastic Microenvironment

SERPINE1：在胆管癌进展中的作用以及促纤维增生微环境中的治疗靶点

影响因子:5.2

doi:10.3390/cells13100796

Czekay, Ralf-Peter; Higgins, Craig E; Aydin, Hasan Basri; Samarakoon, Rohan; Subasi, Nusret Bekir; Higgins, Stephen P; Lee, Hwajeong; Higgins, Paul J

发表日期：2024

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The Genomic Response to TGF-β1 Dictates Failed Repair and Progression of Fibrotic Disease in the Obstructed Kidney

基因组对TGF-β1的反应决定了梗阻肾脏中纤维化疾病的修复失败和进展

期刊:Frontiers in Cell and Developmental Biology

影响因子:4.3

doi:10.3389/fcell.2021.678524

Higgins, Craig E; Tang, Jiaqi; Higgins, Stephen P; Gifford, Cody C; Mian, Badar M; Jones, David M; Zhang, Wenzheng; Costello, Angelica; Conti, David J; Samarakoon, Rohan; Higgins, Paul J

发表日期：2021

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TGF-β1-p53 cooperativity regulates a profibrotic genomic program in the kidney: molecular mechanisms and clinical implications

TGF-β1-p53协同作用调控肾脏促纤维化基因组程序：分子机制和临床意义

期刊:FASEB Journal

影响因子:4.2

doi:10.1096/fj.201900943R

Higgins, Craig E; Tang, Jiaqi; Mian, Badar M; Higgins, Stephen P; Gifford, Cody C; Conti, David J; Meldrum, Kirstan K; Samarakoon, Rohan; Higgins, Paul J

发表日期：2019

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TGF-β1/p53 signaling in renal fibrogenesis

TGF-β1/p53信号通路在肾纤维化发生中的作用

期刊:Cellular Signalling

影响因子:3.7

doi:10.1016/j.cellsig.2017.11.005

Higgins, Stephen P; Tang, Yi; Higgins, Craig E; Mian, Badar; Zhang, Wenzheng; Czekay, Ralf-Peter; Samarakoon, Rohan; Conti, David J; Higgins, Paul J

发表日期：2018

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A small molecule PAI-1 functional inhibitor attenuates neointimal hyperplasia and vascular smooth muscle cell survival by promoting PAI-1 cleavage.

小分子 PAI-1 功能抑制剂通过促进 PAI-1 裂解来减弱新生内膜增生和血管平滑肌细胞存活

期刊:Cellular Signalling

影响因子:3.7

doi:10.1016/j.cellsig.2015.01.009

Simone Tessa M, Higgins Stephen P, Archambeault Jaclyn, Higgins Craig E, Ginnan Roman G, Singer Harold, Higgins Paul J

细胞生物学

发表日期：2015

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SERPINE1: A Molecular Switch in the Proliferation-Migration Dichotomy in Wound-"Activated" Keratinocytes

SERPINE1：伤口“激活”角质形成细胞增殖-迁移二分法中的分子开关

期刊:Advances in Wound Care

影响因子:5.6

doi:10.1089/wound.2013.0512

Simone, Tessa M; Higgins, Craig E; Czekay, Ralf-Peter; Law, Brian K; Higgins, Stephen P; Archambeault, Jaclyn; Kutz, Stacie M; Higgins, Paul J

细胞生物学

发表日期：2014

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The basic helix-loop-helix/leucine zipper transcription factor USF2 integrates serum-induced PAI-1 expression and keratinocyte growth

碱性螺旋-环-螺旋/亮氨酸拉链转录因子USF2整合了血清诱导的PAI-1表达和角质形成细胞生长。

期刊:Journal of Cellular Biochemistry

影响因子:2.8

doi:10.1002/jcb.24861

Qi, Li; Higgins, Craig E; Higgins, Stephen P; Law, Brian K; Simone, Tessa M; Higgins, Paul J

细胞生物学

发表日期：2014

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Chemical Antagonists of Plasminogen Activator Inhibitor-1: Mechanisms of Action and Therapeutic Potential in Vascular Disease

纤溶酶原激活物抑制剂-1的化学拮抗剂：作用机制及其在血管疾病中的治疗潜力

doi:10.4172/1747-0862.1000125

Simone, Tessa M; Higgins, Stephen P; Higgins, Craig E; Lennartz, Michelle R; Higgins, Paul J

发表日期：2014

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Complex Regulation of the Pericellular Proteolytic Microenvironment during Tumor Progression and Wound Repair: Functional Interactions between the Serine Protease and Matrix Metalloproteinase Cascades

肿瘤进展和伤口修复过程中细胞周围蛋白水解微环境的复杂调控：丝氨酸蛋白酶和基质金属蛋白酶级联之间的功能相互作用

期刊:Biochemistry Research International

影响因子:3.4

doi:10.1155/2012/454368

Wilkins-Port, Cynthia E; Higgins, Stephen P; Higgins, Craig E; Kobori-Hotchkiss, Issey; Higgins, Paul J

细胞生物学

发表日期：2012

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