日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

ATRX loss couples genome instability at a G-rich repeat to dysregulation of human alpha-globin expression.

ATRX 的缺失导致富含 G 的重复序列处的基因组不稳定性与人类 α-珠蛋白表达失调有关。

Shen Yuqi, Gupta Kinam, Tan-Wong Sue Mei, Wen Sean, Fisher Christopher A, Tamon Liezel, Proudfoot Nicholas J, Gibbons Richard J, Higgs Douglas R

A functional overlap between actively transcribed genes and chromatin insulator elements.

活跃转录基因与染色质绝缘元件之间存在功能重叠。

Cornell Lucy J, Harrold Caroline L, Holliman Susannah, Tsang Felice, Gosden Matthew E, Hanssen Lars L P, Stolper Rosa, Downes Damien J, Biggs Daniel, Preece Chris, Alghadban Samy, Sharpe Jacqueline A, Davies Benjamin, Sloane-Stanley Jacqueline A, Hughes Jim R, Higgs Douglas R, Kassouf Mira T

Active regulatory elements recruit cohesin to establish cell specific chromatin domains.

活性调控元件募集黏连蛋白以建立细胞特异性染色质结构域

Georgiades Emily, Harrold Caroline, Roberts Nigel, Kassouf Mira, Riva Simone G, Sanders Edward, Downes Damien, Francis Helena S, Blayney Joseph, Oudelaar A Marieke, Milne Thomas A, Higgs Douglas, Hughes Jim R

Identification of new candidate drugs in myelodysplastic syndromes with splicing factor mutations by transcriptional profiling and connectivity map analysis

通过转录谱分析和连接图谱分析鉴定伴有剪接因子突变的骨髓增生异常综合征的新候选药物

Sun, Tianyu; Singh, Shalini; Wang, Hayson Chenyu; Lee, Juseong; Dolatshad, Hamid; Cheong, Pak Leng; Higgs, Douglas R; Boultwood, Jacqueline; Pellagatti, Andrea

Interspecies regulatory landscapes and elements revealed by novel joint systematic integration of human and mouse blood cell epigenomes

通过对人类和小鼠血细胞表观基因组进行新型联合系统整合,揭示了物种间的调控格局和要素

Xiang, Guanjue; He, Xi; Giardine, Belinda M; Isaac, Kathryn J; Taylor, Dylan J; McCoy, Rajiv C; Jansen, Camden; Keller, Cheryl A; Wixom, Alexander Q; Cockburn, April; Miller, Amber; Qi, Qian; He, Yanghua; Li, Yichao; Lichtenberg, Jens; Heuston, Elisabeth F; Anderson, Stacie M; Luan, Jing; Vermunt, Marit W; Yue, Feng; Sauria, Michael E G; Schatz, Michael C; Taylor, James; Göttgens, Berthold; Hughes, Jim R; Higgs, Douglas R; Weiss, Mitchell J; Cheng, Yong; Blobel, Gerd A; Bodine, David M; Zhang, Yu; Li, Qunhua; Mahony, Shaun; Hardison, Ross C

Loss-of-Function Variants in SUPT5H as Modifying Factors in Beta-Thalassemia

SUPT5H 功能缺失变异体作为β-地中海贫血的修饰因子

Harteveld, Cornelis L; Achour, Ahlem; Fairuz Mohd Hasan, Nik Fatma; Legebeke, Jelmer; Arkesteijn, Sandra J G; Huurne, Jeanet Ter; Verschuren, Maaike; Bhagwandien-Bisoen, Sharda; Schaap, Rianne; Vijfhuizen, Linda; Idrissi, Hakima El; Babbs, Christian; Higgs, Douglas R; Koopmann, Tamara T; Vrettou, Christina; Traeger-Synodinos, Joanne; Baas, Frank

RNA polymerase II pausing temporally coordinates cell cycle progression and erythroid differentiation.

RNA聚合酶II的暂停在时间上协调细胞周期进程和红系分化

Martell Danya J, Merens Hope E, Caulier Alexis, Fiorini Claudia, Ulirsch Jacob C, Ietswaart Robert, Choquet Karine, Graziadei Giovanna, Brancaleoni Valentina, Cappellini Maria Domenica, Scott Caroline, Roberts Nigel, Proven Melanie, Roy Noémi B A, Babbs Christian, Higgs Douglas R, Sankaran Vijay G, Churchman L Stirling

Scalable in vitro production of defined mouse erythroblasts

可规模化体外生产特定小鼠成红细胞

Francis, Helena S; Harold, Caroline L; Beagrie, Robert A; King, Andrew J; Gosden, Matthew E; Blayney, Joseph W; Jeziorska, Danuta M; Babbs, Christian; Higgs, Douglas R; Kassouf, Mira T

The EHA Research Roadmap: Normal Hematopoiesis

EHA研究路线图:正常造血

Jaffredo, Thierry; Balduini, Alessandra; Bigas, Anna; Bernardi, Rosa; Bonnet, Dominique; Canque, Bruno; Charbord, Pierre; Cumano, Anna; Delwel, Ruud; Durand, Charles; Fibbe, Willem; Forrester, Lesley; de Franceschi, Lucia; Ghevaert, Cedric; Gjertsen, Bjørn; Gottgens, Berthold; Graf, Thomas; Heidenreich, Olaf; Hermine, Olivier; Higgs, Douglas; Kleanthous, Marina; Klump, Hannes; Kouskoff, Valerie; Krause, Daniela; Lacaud, George; Celso, Cristina Lo; Martens, Joost H A; Méndez-Ferrer, Simón; Menendez, Pablo; Oostendorp, Robert; Philipsen, Sjaak; Porse, Bo; Raaijmakers, Marc; Robin, Catherine; Stunnenberg, Henk; Theilgaard-Mönch, Kim; Touw, Ivo; Vainchenker, William; Corrons, Joan-Lluis Vives; Yvernogeau, Laurent; Schuringa, Jan Jacob

Recapitulation of erythropoiesis in congenital dyserythropoietic anaemia type I (CDA-I) identifies defects in differentiation and nucleolar abnormalities

先天性红细胞生成障碍性贫血 I 型 (CDA-I) 红细胞生成过程的重现可识别分化缺陷和核仁异常

Scott, Caroline; Downes, Damien J; Brown, Jill M; Beagrie, Robert; Olijnik, Aude-Anais; Gosden, Matthew; Schwessinger, Ron; Fisher, Christopher A; Rose, Anna; Ferguson, David J P; Johnson, Errin; Hill, Quentin A; Okoli, Steven; Renella, Raffaele; Ryan, Kate; Brand, Marjorie; Hughes, Jim; Roy, Noemi B A; Higgs, Douglas R; Babbs, Christian; Buckle, Veronica J