日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Enhancing the Outcome of Crystallographic Fragment Screening by Choosing the Optimal Protein Crystal Form

通过选择最佳蛋白质晶体形式来提高晶体学片段筛选的结果

Barthel, Tatjana; Wollenhaupt, Jan; Benz, Laila S; Reinke, Patrick; Zhang, Linlin; Oelker, Melanie; Lennartz, Frank; Taberman, Helena; Mueller, Uwe; Meents, Alke; Hilgenfeld, Rolf; Weiss, Manfred S

A coronavirus assembly inhibitor that targets the viral membrane protein.

一种针对病毒膜蛋白的冠状病毒组装抑制剂

Laporte Manon, Jochmans Dirk, Bardiot Dorothée, Desmarets Lowiese, Debski-Antoniak Oliver J, Mizzon Giulia, Abdelnabi Rana, Leyssen Pieter, Chiu Winston, Zhang Zhikuan, Nomura Norimichi, Boland Sandro, Ohto Umeharu, Stahl Yannick, Wuyts Jurgen, De Jonghe Steven, Stevaert Annelies, van Hemert Martijn J, Bontes Brenda W, Wanningen Patrick, Groenewold G J Mirjam, Zegar Aneta, Owczarek Katarzyna, Joshi Sanjata, Koukni Mohamed, Arzel Philippe, Klaassen Hugo, Vanherck Jean-Christophe, Vandecaetsbeek Ilse, Cremers Niels, Donckers Kim, Francken Thibault, Van Buyten Tina, Rymenants Jasper, Schepers Joost, Pyrc Krzysztof, Hilgenfeld Rolf, Dubuisson Jean, Bosch Berend-Jan, Van Kuppeveld Frank, Eydoux Cecilia, Decroly Etienne, Canard Bruno, Naesens Lieve, Weynand Birgit, Snijder Eric J, Belouzard Sandrine, Shimizu Toshiyuki, Bartenschlager Ralf, Hurdiss Daniel L, Marchand Arnaud, Chaltin Patrick, Neyts Johan

Structure-Based Optimization of Pyridone α-Ketoamides as Inhibitors of the SARS-CoV-2 Main Protease

基于结构的吡啶酮α-酮酰胺类化合物作为SARS-CoV-2主蛋白酶抑制剂的优化

Akula, Ravi Kumar; El Kilani, Haifa; Metzen, Alina; Röske, Judith; Zhang, Kaixuan; Göhl, Matthias; Arisetti, Nanaji; Marsh, Graham P; Maple, Hannah J; Cooper, Mark S; Karadogan, Burhan; Jochmans, Dirk; Neyts, Johan; Rox, Katharina; Hilgenfeld, Rolf; Brönstrup, Mark

Profiling of coronaviral M(pro) and enteroviral 3C(pro) specificity provides a framework for the development of broad-spectrum antiviral compounds

对冠状病毒M蛋白和肠道病毒3C蛋白特异性的分析为开发广谱抗病毒化合物提供了框架。

Rut, Wioletta; Groborz, Katarzyna; Sun, Xinyuanyuan; Hilgenfeld, Rolf; Drag, Marcin

Why is the Omicron main protease of SARS-CoV-2 less stable than its wild-type counterpart? A crystallographic, biophysical, and theoretical study of the free enzyme and its complex with inhibitor 13b-K

为什么SARS-CoV-2的Omicron主蛋白酶比其野生型对应物稳定性更低?一项关于游离酶及其与抑制剂13b-K复合物的晶体学、生物物理学和理论研究。

Ibrahim, Mohamed; Sun, Xinyuanyuan; de Oliveira, Vinicius Martins; Liu, Ruibin; Clayton, Joseph; El Kilani, Haifa; Shen, Jana; Hilgenfeld, Rolf

Practical courses on advanced methods in macromolecular crystallization: 20 years of history and future perspectives

高分子结晶高级方法实用课程:20 年历史与未来展望

Havlickova, Petra; Gavira, Jose A; Mesters, Jeroen R; Koutska, Anna; Kascakova, Barbora; Prudnikova, Tatyana; Hilgenfeld, Rolf; Garcia-Ruiz, Juan Manuel; Rezacova, Pavlina; Kuta Smatanova, Ivana

Why is the Omicron main protease of SARS-CoV-2 less stable than its wild-type counterpart? A crystallographic, biophysical, and theoretical study

为什么SARS-CoV-2的Omicron主蛋白酶比其野生型对应物稳定性更低?一项晶体学、生物物理学和理论研究

Ibrahim, Mohamed; Sun, Xinyuanyuan; de Oliveira, Vinicius Martins; Liu, Ruibin; Clayton, Joseph; El Kilani, Haifa; Shen, Jana; Hilgenfeld, Rolf

Therapeutic strategies for COVID-19: progress and lessons learned

新冠肺炎治疗策略:进展与经验教训

Li, Guangdi; Hilgenfeld, Rolf; Whitley, Richard; De Clercq, Erik

Integrative Approach to Dissect the Drug Resistance Mechanism of the H172Y Mutation of SARS-CoV-2 Main Protease

采用综合方法解析SARS-CoV-2主蛋白酶H172Y突变的耐药机制

Clayton, Joseph; de Oliveira, Vinícius Martins; Ibrahim, Mohamed Fouad; Sun, Xinyuanyuan; Mahinthichaichan, Paween; Shen, Mingzhe; Hilgenfeld, Rolf; Shen, Jana

An Integrative Approach to Dissect the Drug Resistance Mechanism of the H172Y Mutation of SARS-CoV-2 Main Protease

采用综合方法解析SARS-CoV-2主蛋白酶H172Y突变的耐药机制

Clayton, Joseph; de Oliveira, Vinicius Martins; Ibraham, Mohamed Fouad; Sun, Xinyuanyuan; Mahinthichaichan, Paween; Shen, Mingzhe; Hilgenfeld, Rolf; Shen, Jana