Hillary M Layden相关文献与解析，生知库 | 链接生命科学的每一步

PAX3-FOXO1 coordinates enhancer architecture, eRNA transcription, and RNA polymerase pause release at select gene targets

PAX3-FOXO1 协调特定基因靶点的增强子结构、eRNA 转录和 RNA 聚合酶暂停释放

doi:10.1016/j.molcel.2022.10.025

Susu Zhang ,Jing Wang ,Qi Liu ,W Hayes McDonald ,Monica L Bomber ,Hillary M Layden ,Jacob Ellis ,Scott C Borinstein ,Scott W Hiebert ,Kristy R Stengel

Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss

在 NF1/PTEN 缺失驱动的高危肿瘤中，MCL1 和 BCL2 同时受到抑制，从而导致黑色素瘤细胞协同死亡

期刊:Oncogene

影响因子:6.9

doi:10.1038/s41388-021-01926-y

Shuning He, Mark W Zimmerman, Hillary M Layden, Alla Berezovskaya, Julia Etchin, Megan W Martel, Grace Thurston, Chang-Bin Jing, Ellen van Rooijen, Charles K Kaufman, Scott J Rodig, Leonard I Zon, E Elizabeth Patton, Marc R Mansour, A Thomas Look

A protocol for rapid degradation of endogenous transcription factors in mammalian cells and identification of direct regulatory targets

一种快速降解哺乳动物细胞内源性转录因子并鉴定其直接调控靶点的方案

期刊:STAR Protocols

影响因子:1.3

doi:10.1016/j.xpro.2021.100530

Hillary M Layden ，Nicholas A Eleuteri ，Scott W Hiebert ，Kristy R Stengel

Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain

神经母细胞瘤中 NF1 缺失与 MYCN 过表达之间的协同作用由 GAP 相关结构域介导

期刊:Elife

影响因子:6.4

doi:10.7554/eLife.14713

Shuning He, Marc R Mansour, Mark W Zimmerman, Dong Hyuk Ki, Hillary M Layden, Koshi Akahane, Evisa Gjini, Eric D de Groh, Antonio R Perez-Atayde, Shizhen Zhu, Jonathan A Epstein, A Thomas Look

Mutant FOXO1 controls an oncogenic network via enhancer accessibility

突变型FOXO1通过增强子可及性调控致癌网络。

Human SMARCA5 is continuously required to maintain nucleosome spacing

人类SMARCA5蛋白持续发挥作用，维持核小体间距。

PAX3-FOXO1 coordinates enhancer architecture, eRNA transcription, and RNA polymerase pause release at select gene targets

PAX3-FOXO1 协调特定基因靶点的增强子结构、eRNA 转录和 RNA 聚合酶暂停释放

Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss

在 NF1/PTEN 缺失驱动的高危肿瘤中，MCL1 和 BCL2 同时受到抑制，从而导致黑色素瘤细胞协同死亡

A protocol for rapid degradation of endogenous transcription factors in mammalian cells and identification of direct regulatory targets

一种快速降解哺乳动物细胞内源性转录因子并鉴定其直接调控靶点的方案

Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain

神经母细胞瘤中 NF1 缺失与 MYCN 过表达之间的协同作用由 GAP 相关结构域介导