日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mapping SCA1 regional vulnerabilities reveals neural and skeletal muscle contributions to disease

绘制 SCA1 区域脆弱性图可揭示神经和骨骼肌对疾病的贡献

Lisa Duvick, W Michael Southern, Kellie A Benzow, Zoe N Burch, Hillary P Handler, Jason S Mitchell, Hannah Kuivinen, Udaya Gadiparthi, Praseuth Yang, Alyssa Soles, Carrie A Sheeler, Orion Rainwater, Shannah Serres, Erin B Lind, Tessa Nichols-Meade, Yun You, Brennon O'Callaghan, Huda Y Zoghbi, Marija

Decreasing mutant ATXN1 nuclear localization improves a spectrum of SCA1-like phenotypes and brain region transcriptomic profiles

降低突变型 ATXN1 的核定位可改善一系列 SCA1 样表型和脑区转录组谱

Hillary P Handler, Lisa Duvick, Jason S Mitchell, Marija Cvetanovic, Molly Reighard, Alyssa Soles, Kathleen B Mather, Orion Rainwater, Shannah Serres, Tessa Nichols-Meade, Stephanie L Coffin, Yun You, Brian L Ruis, Brennon O'Callaghan, Christine Henzler, Huda Y Zoghbi, Harry T Orr

Disruption of the ATXN1-CIC complex reveals the role of additional nuclear ATXN1 interactors in spinocerebellar ataxia type 1

ATXN1-CIC 复合物的破坏揭示了额外的核 ATXN1 相互作用蛋白在 1 型脊髓小脑性共济失调中的作用

Stephanie L Coffin, Mark A Durham, Larissa Nitschke, Eder Xhako, Amanda M Brown, Jean-Pierre Revelli, Esmeralda Villavicencio Gonzalez, Tao Lin, Hillary P Handler, Yanwan Dai, Alexander J Trostle, Ying-Wooi Wan, Zhandong Liu, Roy V Sillitoe, Harry T Orr, Huda Y Zoghbi

BDNF is altered in a brain-region specific manner and rescues deficits in Spinocerebellar Ataxia Type 1

BDNF 以大脑区域特定的方式发生改变,并挽救 1 型脊髓小脑共济失调的缺陷

Juao-Guilherme Rosa, Katherine Hamel, Alyssa Soles, Carrie Sheeler, Ella Borgenheimer, Stephen Gilliat, Kaelin Sbrocco, Ferris Ghanoum, Hillary P Handler, Colleen Forster, Orion Rainwater, Marija Cvetanovic2

Increased intrinsic membrane excitability is associated with hypertrophic olivary degeneration in spinocerebellar ataxia type 1

内在膜兴奋性的增加与 1 型脊髓小脑共济失调的肥大性橄榄变性有关

Logan M Morrison, Haoran Huang, Hillary P Handler, Min Fu, David D Bushart, Samuel S Pappas, Harry T Orr, Vikram G Shakkottai

Delineating regional vulnerability in the neurodegenerative disease SCA1 using a conditional mutant ATXN1 mouse

使用条件突变 ATXN1 小鼠描绘神经退行性疾病 SCA1 的区域脆弱性

Lisa Duvick, W Michael Southern, Kellie Benzow, Zoe N Burch, Hillary P Handler, Jason S Mitchell, Hannah Kuivinen, Udaya Keerthy Gadiparthi, Praseuth Yang, Alyssa Soles, Carrie Scheeler, Orion Rainwater, Shannah Serres, Erin Lind, Tessa Nichols-Meade, Brennon O'Callaghan, Huda Y Zoghbi, Marija Cveta

Spatial and Temporal Diversity of Astrocyte Phenotypes in Spinocerebellar Ataxia Type 1 Mice

脊髓小脑共济失调 1 型小鼠星形胶质细胞表型的空间和时间多样性

Juao-Guilherme Rosa, Katherine Hamel, Carrie Sheeler, Ella Borgenheimer, Stephen Gilliat, Alyssa Soles, Ferris J Ghannoum, Kaelin Sbrocco, Hillary P Handler, Orion Rainwater, Ryan Kang, Marija Cvetanovic

Antisense Oligonucleotide Therapeutic Approach for Suppression of Ataxin-1 Expression: A Safety Assessment

反义寡核苷酸疗法抑制 Ataxin-1 表达:安全性评估

Brennon O'Callaghan, Bente Hofstra, Hillary P Handler, Holly B Kordasiewicz, Tracy Cole, Lisa Duvick, Jillian Friedrich, Orion Rainwater, Praseuth Yang, Michael Benneyworth, Tessa Nichols-Meade, Wesley Heal, Rachel Ter Haar, Christine Henzler, Harry T Orr

Altered Capicua expression drives regional Purkinje neuron vulnerability through ion channel gene dysregulation in spinocerebellar ataxia type 1

在 1 型脊髓小脑性共济失调中,Capicua 表达改变通过离子通道基因失调导致区域性浦肯野神经元脆弱性

Ravi Chopra, David D Bushart, John P Cooper, Dhananjay Yellajoshyula, Logan M Morrison, Haoran Huang, Hillary P Handler, Luke J Man, Warunee Dansithong, Daniel R Scoles, Stefan M Pulst, Harry T Orr, Vikram G Shakkottai

Antisense oligonucleotide-mediated ataxin-1 reduction prolongs survival in SCA1 mice and reveals disease-associated transcriptome profiles

反义寡核苷酸介导的 Ataxin-1 减少可延长 SCA1 小鼠的生存期并揭示与疾病相关的转录组谱

Jillian Friedrich, Holly B Kordasiewicz, Brennon O'Callaghan, Hillary P Handler, Carmen Wagener, Lisa Duvick, Eric E Swayze, Orion Rainwater, Bente Hofstra, Michael Benneyworth, Tessa Nichols-Meade, Praseuth Yang, Zhao Chen, Judit Perez Ortiz, H Brent Clark, Gülin Öz, Sarah Larson, Huda Y Zoghbi, Ch