日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo

细胞因子信号抑制因子-1的SOCS盒对于体内细胞因子活性的抑制至关重要。

Zhang, J G; Metcalf, D; Rakar, S; Asimakis, M; Greenhalgh, C J; Willson, T A; Starr, R; Nicholson, S E; Carter, W; Alexander, W S; Hilton, D J; Nicola, N A

SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice

SOCS1缺陷会导致乳腺发育加速,并能挽救催乳素受体缺陷小鼠的泌乳功能。

Lindeman, G J; Wittlin, S; Lada, H; Naylor, M J; Santamaria, M; Zhang, J G; Starr, R; Hilton, D J; Alexander, W S; Ormandy, C J; Visvader, J

Functional analysis of Asb-1 using genetic modification in mice.

利用基因改造小鼠对Asb-1进行功能分析

Kile B T, Metcalf D, Mifsud S, DiRago L, Nicola N A, Hilton D J, Alexander W S

Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130

细胞因子信号抑制因子-3优先结合于共享细胞因子受体亚基gp130上的SHP-2结合位点

Nicholson, S E; De Souza, D; Fabri, L J; Corbin, J; Willson, T A; Zhang, J G; Silva, A; Asimakis, M; Farley, A; Nash, A D; Metcalf, D; Hilton, D J; Nicola, N A; Baca, M

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

细胞因子信号抑制因子中保守的SOCS盒基序可与延伸蛋白B和C结合,并可能将结合蛋白与蛋白酶体降解偶联。

Zhang, J G; Farley, A; Nicholson, S E; Willson, T A; Zugaro, L M; Simpson, R J; Moritz, R L; Cary, D; Richardson, R; Hausmann, G; Kile, B T; Kent, S B; Alexander, W S; Metcalf, D; Hilton, D J; Nicola, N A; Baca, M

Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction

SOCS蛋白的突变分析表明,抑制LIF和IL-6信号转导需要双结构域,但抑制机制不同。

Nicholson, S E; Willson, T A; Farley, A; Starr, R; Zhang, J G; Baca, M; Alexander, W S; Metcalf, D; Hilton, D J; Nicola, N A

Negative regulators of cytokine signal transduction

细胞因子信号转导的负调控因子

Hilton, D J

Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1

缺乏细胞因子信号抑制因子-1的小鼠出现肝脏退化和淋巴细胞缺陷

Starr, R; Metcalf, D; Elefanty, A G; Brysha, M; Willson, T A; Nicola, N A; Hilton, D J; Alexander, W S

Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells

瘦素可以诱导造血细胞的增殖、分化和功能激活。

Gainsford, T; Willson, T A; Metcalf, D; Handman, E; McFarlane, C; Ng, A; Nicola, N A; Alexander, W S; Hilton, D J

Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction

小鼠IL-11受体α链的克隆;gp130对于高亲和力结合和信号转导是必需的

Hilton, D J; Hilton, A A; Raicevic, A; Rakar, S; Harrison-Smith, M; Gough, N M; Begley, C G; Metcalf, D; Nicola, N A; Willson, T A