日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A structure-based mRNA vaccine for Nipah virus in healthy adults: a phase 1 trial

针对健康成年人的尼帕病毒结构型mRNA疫苗:一项I期临床试验

Ploquin, Aurélie; Mason, Rosemarie D; Holman, LaSonji A; Happe, Myra; Widge, Alicia T; Novik, Laura; Ortega-Villa, Ana M; Yamshchikov, Galina V; Gordon, Ingelise J; Ola, Abidemi; Arthur, Anita; Costner, Pamela J M; Mendoza, Floreliz; Saunders, Jamie; Wang, Xioalin; Whalen, William R; Utoh, Joanna; Cunningham, Jennifer; Loftus, Lorin N; Heimann, Ashley; Korzeniwsky, Katia; Andrew, Shayne F; Lamb, Evan; Shyam Sunder, Shruthi; Thompson, Amelia; McDonald, Mary; Foulds, Kathryn E; Sullivan, Nancy J; Bahorich, Jessica; Coates, Emily E; Loomis, Rebecca J; Graham, Barney S; Bok, Karin; Himansu, Sunny; Leav, Brett; Dempsey, Walla; Beigel, John H; Roederer, Mario; Dropulic, Lesia K

Virus glycoprotein nanodisc platform for vaccine analytics.

用于疫苗分析的病毒糖蛋白纳米盘平台。

Rantalainen Kimmo, Liguori Alessia, Ozorowski Gabriel, Flynn Claudia, Steichen Jon M, Swanson Olivia M, Madden Patrick J, Baboo Sabyasachi, Phulera Swastik, Gharpure Anant, Lu Danny, Kalyuzhniy Oleksandr, Skog Patrick, Terada Sierra, Shil Monolina, Diedrich Jolene K, Georgeson Erik, Tingle Ryan, Eskandarzadeh Saman, Lee Wen-Hsin, Alavi Nushin, Goodwin Diana, Kubitz Michael, Amirzehni Sonya, Himansu Sunny, Sok Devin, Lee Jeong Hyun, Yates John R 3rd, Paulson James C, Crotty Shane, Schiffner Torben, Ward Andrew B, Schief William R

Divergent antibody recognition profiles are generated by protective mRNA vaccines against Marburg and Ravn viruses

针对马尔堡病毒和拉文病毒的保护性mRNA疫苗会产生不同的抗体识别谱。

Meyer, Michelle; Gunn, Bronwyn M; Pietzsch, Colette; Subramani, Chandru; Kedarinath, Kritika; Villarreal, Paula P; Hyde, Matthew A; Saphire, Erica Ollmann; Crowe, James E Jr; Alter, Galit; Himansu, Sunny; Carfi, Andrea; Bukreyev, Alexander

Inclusion of a retroviral protease enhances the immunogenicity of VLP-forming mRNA vaccines against HIV-1 or SARS-CoV-2 in mice.

在小鼠体内加入逆转录病毒蛋白酶可增强形成病毒样颗粒的mRNA疫苗对HIV-1或SARS-CoV-2的免疫原性

Zhang Peng, Singh Mamta, Becker Vada A, Croft Jacob, Tsybovsky Yaroslav, Gopan Vinay, Seo Yuna, Liu Qingbo, Rogers Denise, Miao Huiyi, Lin Yin, Rogan Daniel, Shields Courtney, Elbashir Sayda M, Calabrese Samantha, Renzi Isabella, Preznyak Vladimir, Narayanan Elizabeth, Stewart-Jones Guillaume, Himansu Sunny, Connors Mark, Lee Kelly, Carfi Andrea, Lusso Paolo

Marburg virus glycoprotein mRNA vaccine is more protective than a virus-like particle-forming mRNA vaccine

马尔堡病毒糖蛋白mRNA疫苗比病毒样颗粒形成mRNA疫苗更具保护作用。

Subramani, Chandru; Meyer, Michelle; Hyde, Matthew A; Comeaux, Margaret E; Hao, Haiping; Crowe, James E Jr; Popov, Vsevolod L; Thaker, Harshwardhan; Himansu, Sunny; Carfi, Andrea; Bukreyev, Alexander

mRNA delivery of circumsporozoite protein epitope-based malaria vaccines induces protection in a mouse model

利用mRNA递送基于环子孢子蛋白表位的疟疾疫苗可在小鼠模型中诱导保护作用

Wu, Nelson R; Beutler, Nathan; Hu, Xiaozhen; Skog, Patrick D; Liguori, Alessia; Flores-Garcia, Yevel; Maiorino, Laura; Terada, Sierra; Lu, Danny; Lai, Yen-Chung; Ndihokubwayo, Justin; Schiffner, Torben; Cottrell, Christopher A; Eskandarzadeh, Saman; Alavi, Nushin; Kubitz, Michael; Phelps, Nicole; Tingle, Ryan; Hodges, Sam; Youhanna, John E; Amirzehni, Sonya; Irvine, Darrell J; Himansu, Sunny; Zavala, Fidel; Rogers, Thomas F; Burton, Dennis R; Schief, William R

Vaccination with mRNA-encoded membrane-anchored HIV envelope trimers elicited tier 2 neutralizing antibodies in a phase 1 clinical trial

在一项 I 期临床试验中,接种 mRNA 编码的膜锚定 HIV 包膜三聚体疫苗可诱导产生 2 级中和抗体。

Parks, K Rachael; Moodie, Zoe; Allen, Mary A; Yen, Catherine; Furch, Briana D; MacPhee, Kellie J; Ozorowski, Gabriel; Heptinstall, Jack; Hahn, William O; Zheng, Zihan; Lu, Huiyin; Grant, Shannon; Domin, Elize; Duff, Michael O; Seese, Aaron; Marini-Macouzet, Constanza; Ballweber-Fleming, Lamar; Lee, Wen-Hsin; Cottrell, Christopher A; Liguori, Alessia; Georgeson, Erik; Alavi, Nushin; Kubitz, Michael; Phelps, Nicole; Seaton, Kelly E; Cohen, Kristen W; Anderson, Maija A; Mondal, Kajari; Laufer, Dagna S; Kublin, James G; Ward, Andrew B; Hyrien, Ollivier; De Rosa, Stephen C; Himansu, Sunny; Leav, Brett; Reuter, Caroline; Tomaras, Georgia D; Montefiori, David; Walsh, Stephen R; Frank, Ian; Sobieszczyk, Magdalena E; Goepfert, Paul A; Stephenson, Kathryn E; Baden, Lindsey R; Van Tieu, Hong; Keefer, Michael C; Clark, Jesse; Riddler, Sharon A; Schief, William R; McElrath, M Juliana

Simultaneous priming of HIV broadly neutralizing antibody precursors to multiple epitopes by germline-targeting mRNA-LNP immunogens in mouse models

在小鼠模型中,通过靶向种系的mRNA-LNP免疫原同时启动针对多个表位的广谱HIV中和抗体前体

Xie, Zhenfei; Wang, Xuesong; Yan, Yu; Steichen, Jon M; Ma, Krystal M; Cottrell, Christopher A; Melzi, Eleonora; Bottermann, Maria; Villavicencio, Paula Maldonado; Rantalainen, Kimmo; Schiffner, Torben; Warner, John E; Weldon, Stephanie R; Prum, Thavaleak; Ellis-Pugh, Jordan R; Torres, Jonathan L; Jackson, Abigail M; Flynn, Claudia T; Ozorowski, Gabriel; Himansu, Sunny; Carfi, Andrea; Ward, Andrew B; Nair, Usha; Schief, William R; Batista, Facundo D

Germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques.

针对种系 HIV 免疫原的免疫原可诱导非近交系猕猴产生交叉中和抗体。

Mishra Nitesh, Liang Bo, Roark Ryan S, Ghosh Amrit, Callaghan Sean, Lee Wen-Hsin, Li Xuduo, Vo Anh L, Avillion Gabriel, Chowdhury Rohan Roy, Habib Rumi H, Bibollet-Ruche Frederic, Giese Gabriella, Oberoi Prabhgun, Amereh Khaled, Somanathan Anjali, Zhu Yuxin, Zhang Yuexiu, Kassab Muzaffer, Tjio Lifei, Andrabi Sharaf, Reyes Raphael A, Allen Joel D, James Nicole E, Randall Kipchoge N Jr, van der Maas Lara, Ben-Akiva Elana, Kacmarek-Michaels Kasia, Plante Samantha, Martella Christian L, Skelly Ashwin N, Singh Ajay, Hurtado Jonathan, Dueker Katharina, Capozzola Tazio, Nedellec Rebecca, Ozorowski Gabriel, Lewis Mark M, Falcone Samantha, Carfi Andrea, Himansu Sunny, Shapiro Lawrence, Crispin Max, Hahn Beatrice H, Briney Bryan, Irvine Darrell J, Burton Dennis R, Ward Andrew B, Batista Facundo D, Kwong Peter D, Shaw George M, Andrabi Raiees

Antibody feedback establishes an affinity brake in the germinal center.

抗体反馈在生发中心建立亲和力抑制机制。

Yan Yu, Wang Xuesong, Xie Zhenfei, Bader Daniel L V, Lim Ryan H, Ma Krystal M, Cottrell Christopher A, Steichen Jon M, Xu Liling, Villavicencio Paula Maldonado, Akauliya Madhav, Koo Ja-Hyun, Shen Jacqueline Ming, Vernich Alexandra, Kalyuzhniy Oleksandr, Allen Joel D, Albowaidey Ali A, Alicea Anthony, Chen Bingxian, Georgeson Erik, Ellis-Pugh Jordan Renae, Alavi Nushin, Esposito Abigail, Naili Hannah, Phelps Nicole, Kelley Brendon, Kubitz Michael, Phan Quynh Anh, Liguori Alessia, Prum Thavaleak, Tingle Ryan, Lu Danny, Eskandarzadeh Saman, Liu Xiaotie, Warner John E, Weldon Stephanie R, Himansu Sunny, Crispin Max, Nair Usha, Liu Sophia, Schief William R, Batista Facundo D