日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Dynamic Behavior and Substrate Interactions of the Polymyxin Resistance Determinant MCR-1 Investigated by Molecular Dynamics Simulations in the Membrane Environment

利用分子动力学模拟研究膜环境中多粘菌素耐药决定簇MCR-1的动态行为和底物相互作用

Lythell, Emily; Badley, Jack; Suardíaz, Reynier; Gurr, Catherine R; Tooke, Catherine L; Hinchliffe, Philip; Oliveira, A Sofia F; Van der Kamp, Marc W; Spencer, James; Mulholland, Adrian J

A global survey of intramolecular isopeptide bonds

全球分子内异肽键调查

Costa, Francesco; Riziotis, Ioannis; Andreeva, Antonina; Kalwan, Delhi; de Jong, Jennifer; Hinchliffe, Philip; Parmeggiani, Fabio; Race, Paul R; Burston, Steven G; Bateman, Alex; Barringer, Rob

Active site loops of membrane-anchored metallo-β-lactamases from environmental bacteria determine cephalosporinase activity

环境细菌膜锚定金属β-内酰胺酶的活性位点环决定头孢菌素酶的活性

Carnevale, Matías C; Palacios, Antonela R; Hinchliffe, Philip; Delmonti, Juliana; Drusin, Salvador I; Moreno, Diego M; Bonomo, Robert A; Spencer, James; Vila, Alejandro J

Mechanistic basis for inhibition of the extended-spectrum β-lactamase GES-1 by enmetazobactam and tazobactam

恩美他唑巴坦和他唑巴坦抑制超广谱β-内酰胺酶GES-1的机制基础

Beer, Michael; Hinchliffe, Philip; Hanževački, Marko; Bethel, Christopher R; Tooke, Catherine L; Van der Kamp, Marc W; Papp-Wallace, Krisztina M; Bonomo, Robert A; Shapiro, Stuart; Mulholland, Adrian J; Spencer, James

All Roads Lead to Carbinolamine: QM/MM Study of Enzymatic C-N Bond Cleavage in Anaerobic Glycyl Radical Enzyme Choline Trimethylamine-Lyase (CutC)

殊途同归:厌氧甘氨酰自由基酶胆碱三甲胺裂解酶 (CutC) 中酶促 CN 键断裂的 QM/MM 研究

Hanzevacki, Marko; Güven, J Jasmin; Hinchliffe, Philip; Shaw, John; Mey, Antonia S J S; Fey, Natalie; Spencer, James; Mulholland, Adrian J

Dynamical responses predict a distal site that modulates activity in an antibiotic resistance enzyme

动态响应预测远端位点能够调节抗生素耐药酶的活性。

Beer, Michael; Oliveira, Ana Sofia F; Tooke, Catherine L; Hinchliffe, Philip; Tsz Yan Li, Angie; Balega, Balazs; Spencer, James; Mulholland, Adrian J

Rational Design of Benzobisheterocycle Metallo-β-Lactamase Inhibitors: A Tricyclic Scaffold Enhances Potency against Target Enzymes

苯并双杂环金属β-内酰胺酶抑制剂的合理设计:三环骨架增强对靶酶的抑制活性

Villamil, Valentina; Rossi, Maria-Agustina; Mojica, Maria F; Hinchliffe, Philip; Martínez, Verónica; Castillo, Valerie; Saiz, Cecilia; Banchio, Claudia; Macías, Mario A; Spencer, James; Bonomo, Robert A; Vila, Alejandro; Moreno, Diego M; Mahler, Graciela

Correction: 2-Mercaptomethyl-thiazolidines use conserved aromatic-S interactions to achieve broad-range inhibition of metallo-β-lactamases

更正:2-巯基甲基噻唑烷利用保守的芳香-S相互作用实现对金属β-内酰胺酶的广谱抑制。

Rossi, Maria-Agustina; Martinez, Veronica; Hinchliffe, Philip; Mojica, Maria F; Castillo, Valerie; Moreno, Diego M; Smith, Ryan; Spellberg, Brad; Drusano, George L; Banchio, Claudia; Bonomo, Robert A; Spencer, James; Vila, Alejandro J; Mahler, Graciela

An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography.

一种利用连续晶体学方法研究酶催化的按需逐滴法

Butryn Agata, Simon Philipp S, Aller Pierre, Hinchliffe Philip, Massad Ramzi N, Leen Gabriel, Tooke Catherine L, Bogacz Isabel, Kim In-Sik, Bhowmick Asmit, Brewster Aaron S, Devenish Nicholas E, Brem Jürgen, Kamps Jos J A G, Lang Pauline A, Rabe Patrick, Axford Danny, Beale John H, Davy Bradley, Ebrahim Ali, Orlans Julien, Storm Selina L S, Zhou Tiankun, Owada Shigeki, Tanaka Rie, Tono Kensuke, Evans Gwyndaf, Owen Robin L, Houle Frances A, Sauter Nicholas K, Schofield Christopher J, Spencer James, Yachandra Vittal K, Yano Junko, Kern Jan F, Orville Allen M

2-Mercaptomethyl-thiazolidines use conserved aromatic-S interactions to achieve broad-range inhibition of metallo-β-lactamases

2-巯基甲基噻唑烷类化合物利用保守的芳香-S相互作用,实现对金属β-内酰胺酶的广谱抑制。

Rossi, Maria-Agustina; Martinez, Veronica; Hinchliffe, Philip; Mojica, Maria F; Castillo, Valerie; Moreno, Diego M; Smith, Ryan; Spellberg, Brad; Drusano, George L; Banchio, Claudia; Bonomo, Robert A; Spencer, James; Vila, Alejandro J; Mahler, Graciela