日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Engineering a compact high-fidelity Staphylococcus aureus Cas9 variant with broader targeting range and mechanistic insights into its activation

构建一种结构紧凑、高保真度的金黄色葡萄球菌Cas9变体,使其具有更广泛的靶向范围,并深入了解其激活机制。

Omura, Satoshi N; Nakagawa, Ryoya; Kajimoto, Shohei; Okazaki, Sae; Ishiguro, Soh; Mori, Hideto; Onishi, Kosuke; Kashiwakura, Yuji; Hiramoto, Takafumi; Horinaka, Kio; Tanaka, Mamoru; Hirano, Hisato; Jividen, Kasey; Yamashita, Keitaro; Tsai, Shengdar Q; Yachie, Nozomu; Ohmori, Tsukasa; Nishimasu, Hiroshi; Nureki, Osamu

Expanded genetic alphabet increases structural and chemical diversity of six-letter DNA for high-affinity protein-targeting aptamers

扩展的遗传字母表增加了六字母DNA的结构和化学多样性,从而提高了高亲和力蛋白质靶向适配体的数量。

Sawada, Kazuhiro; Kimoto, Michiko; Matsunaga, Ken-Ichiro; Tan, Hui Pen; Takayanagi, Ryu; Sano, Fumiya K; Shuto, Yutaro; Hirano, Hisato; Kusakizako, Tsukasa; Itoh, Yuzuru; Kise, Yoshiaki; Hirao, Ichiro; Nureki, Osamu

Insights into G-protein coupling preference from cryo-EM structures of G(q)-bound PTH1R.

从 G(q) 结合的 PTH1R 的冷冻电镜结构中了解 G 蛋白偶联偏好。

Sano Fumiya K, Shimizume Kota, Kobayashi Kazuhiro, Awazu Toshikuni, Kawakami Kouki, Akasaka Hiroaki, Kobayashi Takaaki A, Tanaka Tatsuki, Okamoto Hiroyuki H, Hirano Hisato, Kusakizako Tsukasa, Shihoya Wataru, Kise Yoshiaki, Itoh Yuzuru, Ishitani Ryuichiro, Okada Yasushi, Sako Yasushi, Yanagawa Masataka, Inoue Asuka, Nureki Osamu

Structural basis for target DNA cleavage and guide RNA processing by CRISPR-Casλ2

CRISPR-Casλ2 靶DNA切割和引导RNA加工的结构基础

Omura, Satoshi N; Alfonse, Lauren E; Ornstein, Alexa; Morinaga, Hayato; Hirano, Hisato; Itoh, Yuzuru; Munoz, Gabrielle; Garrity, Anthony J; Hoffman, Gregory R; DiTommaso, Tia; Yan, Winston X; Cheng, David R; Scott, David A; Maben, Zachary; Nureki, Osamu

Structural insights into how Cas9 targets nucleosomes.

Cas9如何靶向核小体的结构解析

Nagamura Reina, Kujirai Tomoya, Kato Junko, Shuto Yutaro, Kusakizako Tsukasa, Hirano Hisato, Endo Masaki, Toki Seiichi, Saika Hiroaki, Kurumizaka Hitoshi, Nureki Osamu

Cryo-EM structure of the transposon-associated TnpB enzyme

转座子相关TnpB酶的冷冻电镜结构

Nakagawa, Ryoya; Hirano, Hisato; Omura, Satoshi N; Nety, Suchita; Kannan, Soumya; Altae-Tran, Han; Yao, Xiao; Sakaguchi, Yuriko; Ohira, Takayuki; Wu, Wen Y; Nakayama, Hiroshi; Shuto, Yutaro; Tanaka, Tatsuki; Sano, Fumiya K; Kusakizako, Tsukasa; Kise, Yoshiaki; Itoh, Yuzuru; Dohmae, Naoshi; van der Oost, John; Suzuki, Tsutomu; Zhang, Feng; Nureki, Osamu