日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Elucidating Compound Mechanism of Action and Polypharmacology with a Large-scale Perturbational Profile Compendium

利用大规模扰动谱汇编阐明化合物的作用机制和多药理学

Hu, Lucas ZhongMing; Hirschhorn, Tal; Douglass, Eugene; Murray, Diana; Trudeau, Stephen J; Turunen, Mikko; Pampou, Sergey; Grunn, Adina; Realubit, Ron; Antolin, Albert A; Wang, Alexander L E; Li, Hai; Subramaniam, Prem; Mundi, Prabhjot S; Karan, Charles; Alvarez, Mariano; Honig, Barry; Stockwell, Brent R; Califano, Andrea

Cysteine depletion induces pancreatic tumor ferroptosis in mice

小鼠体内半胱氨酸耗竭可诱导胰腺肿瘤发生铁死亡。

Badgley, Michael A; Kremer, Daniel M; Maurer, H Carlo; DelGiorno, Kathleen E; Lee, Ho-Joon; Purohit, Vinee; Sagalovskiy, Irina R; Ma, Alice; Kapilian, Jonathan; Firl, Christina E M; Decker, Amanda R; Sastra, Steve A; Palermo, Carmine F; Andrade, Leonardo R; Sajjakulnukit, Peter; Zhang, Li; Tolstyka, Zachary P; Hirschhorn, Tal; Lamb, Candice; Liu, Tong; Gu, Wei; Seeley, E Scott; Stone, Everett; Georgiou, George; Manor, Uri; Iuga, Alina; Wahl, Geoffrey M; Stockwell, Brent R; Lyssiotis, Costas A; Olive, Kenneth P

Mesenchymal subtype neuroblastomas are addicted to TGF-βR2/HMGCR-driven protein geranylgeranylation

间充质亚型神经母细胞瘤依赖于TGF-βR2/HMGCR驱动的蛋白质香叶基香叶基化修饰。

Stokes, Michael E; Small, Jonnell Candice; Vasciaveo, Alessandro; Shimada, Kenichi; Hirschhorn, Tal; Califano, Andrea; Stockwell, Brent R

The development of the concept of ferroptosis

铁死亡概念的发展

Hirschhorn, Tal; Stockwell, Brent R

Differential regulation of translation and endocytosis of alternatively spliced forms of the type II bone morphogenetic protein (BMP) receptor.

II 型骨形态发生蛋白 (BMP) 受体选择性剪接形式的翻译和内吞作用的差异性调控

Amsalem Ayelet R, Marom Barak, Shapira Keren E, Hirschhorn Tal, Preisler Livia, Paarmann Pia, Knaus Petra, Henis Yoav I, Ehrlich Marcelo

Dab2 inhibits the cholesterol-dependent activation of JNK by TGF-β.

Dab2 抑制 TGF-β 介导的胆固醇依赖性 JNK 激活

Shapira Keren E, Hirschhorn Tal, Barzilay Lior, Smorodinsky Nechama I, Henis Yoav I, Ehrlich Marcelo