日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia

白血病相关的 NOTCH1 等位基因是较弱的肿瘤启动因子,但会加速 K-ras 启动的白血病。

Chiang, Mark Y; Xu, Lanwei; Shestova, Olga; Histen, Gavin; L'heureux, Sarah; Romany, Candice; Childs, M Eden; Gimotty, Phyllis A; Aster, Jon C; Pear, Warren S

Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes

NOTCH1异二聚化结构域内的白血病相关突变至少可分为两种不同的机制类型。

Malecki, Michael J; Sanchez-Irizarry, Cheryll; Mitchell, Jennifer L; Histen, Gavin; Xu, Mina L; Aster, Jon C; Blacklow, Stephen C

Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1.

鉴定出影响 NOTCH1 白血病活性的保守负调控序列

Chiang Mark Y, Xu Mina L, Histen Gavin, Shestova Olga, Roy Monideepa, Nam Yunsun, Blacklow Stephen C, Sacks David B, Pear Warren S, Aster Jon C