日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Epigenetic heterogeneity hotspots in human liver disease progression

人类肝病进展中的表观遗传异质性热点

Hlady, Ryan A; Zhao, Xia; El Khoury, Louis Y; Wagner, Ryan T; Luna, Aesis; Pham, Kien; Pyrosopoulos, Nikolaos T; Jain, Dhanpat; Wang, Liguo; Liu, Chen; Robertson, Keith D

SETD2 loss-of-function uniquely sensitizes cells to epigenetic targeting of NSD1-directed H3K36 methylation.

SETD2 功能丧失使细胞对 NSD1 指导的 H3K36 甲基化的表观遗传靶向作用变得异常敏感

Wagner Ryan T, Hlady Ryan A, Pan Xiaoyu, Wang Liguo, Kim Sungho, Zhao Xia, El Khoury Louis Y, Shaikh Shafiq, Zhong Jian, Lee Jeong-Heon, Grembecka Jolanta, Cierpicki Tomasz, Ho Thai H, Robertson Keith D

Extensive intratumor regional epigenetic heterogeneity in clear cell renal cell carcinoma targets kidney enhancers and is associated with poor outcome

透明细胞肾细胞癌中广泛的肿瘤内区域表观遗传异质性靶向肾脏增强子,并与不良预后相关。

El Khoury, Louis Y; Pan, Xiaoyu; Hlady, Ryan A; Wagner, Ryan T; Shaikh, Shafiq; Wang, Liguo; Humphreys, Mitchell R; Castle, Erik P; Stanton, Melissa L; Ho, Thai H; Robertson, Keith D

Identification of DNA methylation signatures associated with poor outcome in lower-risk Stage, Size, Grade and Necrosis (SSIGN) score clear cell renal cell cancer

鉴定与低风险分期、大小、分级和坏死(SSIGN)评分透明细胞肾细胞癌不良预后相关的DNA甲基化特征

El Khoury, Louis Y; Fu, Shuang; Hlady, Ryan A; Wagner, Ryan T; Wang, Liguo; Eckel-Passow, Jeanette E; Castle, Erik P; Stanton, Melissa L; Thompson, R Houston; Parker, Alexander S; Ho, Thai H; Robertson, Keith D

Genome-wide discovery and validation of diagnostic DNA methylation-based biomarkers for hepatocellular cancer detection in circulating cell free DNA

在循环游离DNA中,基于DNA甲基化的肝细胞癌诊断生物标志物的全基因组发现与验证

Hlady, Ryan A; Zhao, Xia; Pan, Xiaoyu; Yang, Ju Dong; Ahmed, Fowsiyo; Antwi, Samuel O; Giama, Nasra H; Patel, Tushar; Roberts, Lewis R; Liu, Chen; Robertson, Keith D

DNA methylation of individual repetitive elements in hepatitis C virus infection-induced hepatocellular carcinoma

丙型肝炎病毒感染诱发的肝细胞癌中单个重复元件的DNA甲基化

Zheng, Yinan; Hlady, Ryan A; Joyce, Brian T; Robertson, Keith D; He, Chunyan; Nannini, Drew R; Kibbe, Warren A; Achenbach, Chad J; Murphy, Robert L; Roberts, Lewis R; Hou, Lifang

DNA methylation age is accelerated in alcohol dependence

酒精依赖会加速DNA甲基化年龄的增加。

Rosen, Allison D; Robertson, Keith D; Hlady, Ryan A; Muench, Christine; Lee, Jisoo; Philibert, Robert; Horvath, Steve; Kaminsky, Zachary A; Lohoff, Falk W

Epigenetics of gastrointestinal diseases: notes from a workshop

胃肠道疾病的表观遗传学:研讨会笔记

Marks, David L; Olson, Rachel L; Urrutia, Raul; Billadeau, Daniel D; Roy, Nilotpal; Calin, George A; Fabbri, Muller; Koutsioumpa, Marina; Iliopoulos, Dimitrios; Ordog, Tamas; Huebert, Robert; Sarmento, Olga; Bamidele, Adebowale O; Faubion, William; Lomberk, Gwen L; Siveke, Jens; Ahuja, Nita; Iovanna, Juan; Hlady, Ryan A; Robertson, Keith; Kisiel, John; Pin, Christopher L; Fernandez-Zapico, Martin E

High fat diet and exercise lead to a disrupted and pathogenic DNA methylome in mouse liver

高脂肪饮食和运动会导致小鼠肝脏DNA甲基化组紊乱并产生致病性改变。

Zhou, Dan; Hlady, Ryan A; Schafer, Marissa J; White, Thomas A; Liu, Chen; Choi, Jeong-Hyeon; Miller, Jordan D; Roberts, Lewis R; LeBrasseur, Nathan K; Robertson, Keith D

Promoter Hypomethylation and Expression Is Conserved in Mouse Chronic Lymphocytic Leukemia Induced by Decreased or Inactivated Dnmt3a

在Dnmt3a减少或失活诱导的小鼠慢性淋巴细胞白血病中,启动子低甲基化和表达是保守的。

Haney, Staci L; Upchurch, G Michael; Opavska, Jana; Klinkebiel, David; Hlady, Ryan A; Suresh, Abhinav; Pirruccello, Samuel J; Shukla, Vipul; Lu, Runqing; Costinean, Stefan; Rizzino, Angie; Karpf, Adam R; Joshi, Shantaram; Swanson, Patrick; Opavsky, Rene