日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

First-in-human phase I/Ib study of NIZ985, a recombinant heterodimer of IL-15 and IL-15Rα, as a single agent and in combination with spartalizumab in patients with advanced and metastatic solid tumors.

首次人体 I/Ib 期研究,评估 NIZ985(IL-15 和 IL-15Rα 的重组异二聚体)作为单药以及与 spartalizumab 联合治疗晚期和转移性实体瘤患者的疗效

Leidner Rom, Conlon Kevin, McNeel Douglas G, Wang-Gillam Andrea, Gupta Sumati, Wesolowski Robert, Chaudhari Monica, Hassounah Nadia, Lee Jong Bong, Ho Lee Lang, O'Keeffe Jessica A, Lewis Nancy, Pavlakis George N, Thompson John A

Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Promotes Macrophage Activation via LDL Receptor-Independent Mechanisms.

前蛋白转化酶枯草杆菌蛋白酶/Kexin 9 (PCSK9) 通过不依赖于 LDL 受体的机制促进巨噬细胞活化

Katsuki Shunsuke, K Jha Prabhash, Lupieri Adrien, Nakano Toshiaki, Passos Livia S A, Rogers Maximillian A, Becker-Greene Dakota, Le Thanh-Dat, Decano Julius L, Ho Lee Lang, Guimaraes Gabriel C, Abdelhamid Ilyes, Halu Arda, Muscoloni Alessandro, V Cannistraci Carlo, Higashi Hideyuki, Zhang Hengmin, Vromman Amélie, Libby Peter, Keith Ozaki C, Sharma Amitabh, Singh Sasha A, Aikawa Elena, Aikawa Masanori

Phase I study of single agent NIZ985, a recombinant heterodimeric IL-15 agonist, in adult patients with metastatic or unresectable solid tumors

一项针对转移性或不可切除实体瘤成年患者的单药 NIZ985(一种重组异二聚体 IL-15 激动剂)的 I 期研究

Conlon, Kevin; Watson, Dionysios C; Waldmann, Thomas A; Valentin, Antonio; Bergamaschi, Cristina; Felber, Barbara K; Peer, Cody J; Figg, William D; Potter, E Lake; Roederer, Mario; McNeel, Douglas G; Thompson, John A; Gupta, Sumati; Leidner, Rom; Wang-Gillam, Andrea; Parikh, Nehal S; Long, Debby; Kurtulus, Sema; Ho Lee, Lang; Chowdhury, Niladri Roy; Bender, Florent; Pavlakis, George N