日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Potent Competitive Inhibitors of Ecto-5'-nucleotidase (CD73) based on 6‑(Het)aryl-7-deazapurine Ribonucleoside 5'‑O‑Bisphosphonates

基于 6-(杂)芳基-7-脱氮嘌呤核糖核苷 5'-O-双膦酸盐的强效 Ecto-5'-核苷酸酶 (CD73) 竞争性抑制剂

期刊:ACS Pharmacology and Translational Science
影响因子:3.7
doi:10.1021/acsptsci.5c00707
Šinkevičiu̅tė, Ugnė; Šímová, Magdalena; Staník, Radek; Poštová Slavětínská, Lenka; Blažková, Kristýna; Šácha, Pavel; Lepšík, Martin; Řezáč, Jan; Konvalinka, Jan; Ormsby, Tereza; Tichý, Michal; Hocek, Michal
CD73
CD7
发表日期：2026
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Super-Resolution Compatible DNA Labeling Technique Reveals Chromatin Mobility and Organization Changes During Differentiation

超高分辨率兼容的DNA标记技术揭示了分化过程中染色质的迁移率和组织结构变化

期刊:Advanced Science
影响因子:14.1
doi:10.1002/advs.202505955
Pabba, Maruthi K; Kuba, Miroslav; Kraus, Tomáš; Celikay, Kerem; Meyer, Janis; Pradhan, Sunil Kumar; Maiser, Andreas; Harz, Hartmann; Leonhardt, Heinrich; Rohr, Karl; Hocek, Michal; Cardoso, M Cristina
发表日期：2025
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Zwitterionic DNA: enzymatic synthesis of hypermodified DNA bearing four different cationic substituents at all four nucleobases

两性离子DNA：酶促合成在所有四个核碱基上带有四种不同阳离子取代基的超修饰DNA

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkaf155
Kuprikova, Natalia; Ondruš, Marek; Bednárová, Lucie; Kraus, Tomáš; Slavětínská, Lenka Poštová; Sýkorová, Veronika; Hocek, Michal
发表日期：2025
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Enzymatic synthesis of reactive RNA probes containing squaramate-linked cytidine or adenosine for bioconjugations and cross-linking with lysine-containing peptides and proteins

利用酶法合成含有方酸连接胞苷或腺苷的反应性RNA探针，用于与含赖氨酸的肽和蛋白质进行生物偶联和交联。

期刊:Communications Chemistry
影响因子:6.2
doi:10.1038/s42004-024-01399-6
Ivancová, Ivana; Quirante, Tania Sánchez; Ondruš, Marek; Pohl, Radek; Vlková, Marta; Žilecká, Eva; Bouřa, Evžen; Hocek, Michal
发表日期：2025
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Hydrophobic alkyl-linked base-modified pyrimidine and 7-deazapurine 2'-deoxyribonucleoside phosphoramidites: synthesis and application in solid-phase synthesis of modified and hypermodified oligonucleotides

疏水烷基连接的碱基修饰嘧啶和7-脱氮嘌呤2'-脱氧核糖核苷亚磷酰胺：合成及其在修饰和超修饰寡核苷酸固相合成中的应用

期刊:RSC Advances
影响因子:4.6
doi:10.1039/d5ra06147d
Jestřábová, Ivana; Bednárová, Lucie; Poštová Slavětínská, Lenka; Hocek, Michal
发表日期：2025
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Enzymatic Synthesis of Modified RNA Containing 5-Methyl- or 5-Ethylpyrimidines or Substituted 7-Deazapurines and Influence of the Modifications on Stability, Translation, and CRISPR-Cas9 Cleavage

含5-甲基嘧啶或5-乙基嘧啶或取代的7-脱氮嘌呤修饰RNA的酶促合成及其对稳定性、翻译和CRISPR-Cas9切割的影响

期刊:ACS Chemical Biology
影响因子:3.8
doi:10.1021/acschembio.5c00692
Sanchez-Quirante, Tania; Kužmová, Erika; Riopedre-Fernandez, Miguel; Golojuch, Sebastian; Vopálenský, Pavel; Raindlová, Veronika; El-Sagheer, Afaf H; Brown, Tom; Hocek, Michal
发表日期：2025
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Polymerase Synthesis of Hypermodified DNA Displaying a Combination of Thiol, Hydroxyl, Carboxylate, and Imidazole Functional Groups in the Major Groove

聚合酶合成在DNA大沟中具有硫醇、羟基、羧酸和咪唑官能团组合的超修饰DNA

期刊:Chemistry-A European Journal
影响因子:3.7
doi:10.1002/chem.202501034
Kaiser, Lukáš; Ondruš, Marek; Poštová Slavětínská, Lenka; Raindlová, Veronika; Hocek, Michal
发表日期：2025
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Identification of 6‑Aryl-7-Deazapurine Ribonucleoside Phosphonates as Inhibitors of Ecto-5'-Nucleotidase (CD73).

鉴定 6'芳基-7-脱氮嘌呤核糖核苷膦酸酯为外-5'-核苷酸酶 (CD73) 抑制剂

期刊:ACS Pharmacology and Translational Science
影响因子:3.7
doi:10.1021/acsptsci.5c00180
Šímová Magdalena, Ormsby Tereza, Å inkevičiuÌ tė Ugnė, Sirotová Veselovská Lucia, Čermáková Kateřina, Hadzima Martin, Bartoň Lenka, Staňurová Jana, Kramná Anežka, Šácha Pavel, Tichý Michal, Hocek Michal, Konvalinka Jan, Blazkova Kristyna
信号转导
发表日期：2025
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Using environment-sensitive tetramethylated thiophene-BODIPY fluorophores in DNA probes for studying effector-induced conformational changes of protein-DNA complexes

利用环境敏感的四甲基噻吩-BODIPY荧光团作为DNA探针，研究效应物诱导的蛋白质-DNA复合物构象变化

期刊:RSC Chemical Biology
影响因子:3.1
doi:10.1039/d4cb00260a
Šoltysová, Markéta; Güixens-Gallardo, Pedro; Sieglová, Irena; Soldánová, Anna; Krejčiříková, Veronika; Fábry, Milan; Brynda, Jiří; Khoroshyy, Petro; Hocek, Michal; Řezáčová, Pavlína
IF
发表日期：2025
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Synthesis of 2-Substituted Adenosine Triphosphate Derivatives and their use in Enzymatic Synthesis and Postsynthetic Labelling of RNA

2-取代腺苷三磷酸衍生物的合成及其在RNA酶促合成和合成后标记中的应用

期刊:Chembiochem
影响因子:2.8
doi:10.1002/cbic.202500241
Šinkevičiūtė, Ugnė; Sanchez-Quirante, Tania; Rožánková, Samanta; Poštová Slavětínská, Lenka; Raindlová, Veronika; Hocek, Michal
发表日期：2025
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