日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells.

B55α和Greatwall表达水平之间的平衡可以预测癌细胞对Greatwall抑制剂的敏感性

Zach Róbert, Annis Michael, Martin-Guerrero Sandra M, Alatawi Abdulrahman, Chia Kim Hou, Meredith Megan, Osborn Kay, Peter Nisha, Pearce William, Booth Jessica, Rajasekaran Mohan, Dias Samantha, Coleman-Evans Lily, Foster William R, Harper Jon A, Herbert Alex D, Tighe Catherine, Reuillon Tristan, West Ryan, Busby Oliver, Burdova Kamila, Crepin Damien, Ortoll Sergi, Vaeteewoottacharn Kulthida, Dejsuphong Donniphat, Spencer John, Patel Hitesh, Le Grand Darren, Hunt Thomas A, Andrews David M, Yamano Hiroyuki, Cutillas Pedro R, Oliver Antony W, Ward Simon E, Hochegger Helfrid

A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct

通过对最小激酶结构域构建体进行结构和功能表征,开发出第一代人长城激酶抑制剂。

Ocasio, Cory A; Rajasekaran, Mohan B; Walker, Sarah; Le Grand, Darren; Spencer, John; Pearl, Frances M G; Ward, Simon E; Savic, Velibor; Pearl, Laurence H; Hochegger, Helfrid; Oliver, Antony W

Aurora at the pole and equator: overlapping functions of Aurora kinases in the mitotic spindle

极光在极地和赤道:极光激酶在有丝分裂纺锤体中的重叠功能

Hochegger, Helfrid; Hégarat, Nadia; Pereira-Leal, Jose B

RAD18 and poly(ADP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair

RAD18 和聚(ADP-核糖)聚合酶各自独立地抑制非同源末端连接对双链断裂的接近,并促进同源重组介导的修复。

Saberi, Alihossein; Hochegger, Helfrid; Szuts, David; Lan, Li; Yasui, Akira; Sale, Julian E; Taniguchi, Yoshihito; Murakawa, Yasuhiro; Zeng, Weihua; Yokomori, Kyoko; Helleday, Thomas; Teraoka, Hirobumi; Arakawa, Hiroshi; Buerstedde, Jean-Marie; Takeda, Shunichi

Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase

聚(ADP-核糖)聚合酶1与聚(ADP-核糖)糖苷水解酶协同作用,加速单链断裂修复。

Fisher, Anna E O; Hochegger, Helfrid; Takeda, Shunichi; Caldecott, Keith W

Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells

在脊椎动物细胞中,Parp-1 可保护同源重组免受 Ku 和连接酶 IV 的干扰。

Hochegger, Helfrid; Dejsuphong, Donniphat; Fukushima, Toru; Morrison, Ciaran; Sonoda, Eiichiro; Schreiber, Valérie; Zhao, Guang Yu; Saberi, Alihossein; Masutani, Mitsuko; Adachi, Noritaka; Koyama, Hideki; de Murcia, Gilbert; Takeda, Shunichi

Fen-1 facilitates homologous recombination by removing divergent sequences at DNA break ends

Fen-1 通过去除 DNA 断裂末端的差异序列来促进同源重组

Kikuchi, Koji; Taniguchi, Yoshihito; Hatanaka, Atsushi; Sonoda, Eiichiro; Hochegger, Helfrid; Adachi, Noritaka; Matsuzaki, Yasuo; Koyama, Hideki; van Gent, Dik C; Jasin, Maria; Takeda, Shunichi