日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Discovery of BI-2493, a Pan-KRAS Inhibitor Showing In Vivo Efficacy.

发现 BI-2493，一种泛 KRAS 抑制剂，显示出体内疗效

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c00576
Bröker Joachim, Waterson Alex G, Hodges Timothy R, Abbott Jason R, Arnold Allison, Böttcher Jark, Braun Nina, Cui Jianwen, Fuchs Julian E, Gerstberger Thomas, Gogg Sebastian, Hanner Sabine, Herdeis Lorenz, Howell Lucas W, Mantoulidis Andreas, Mayer Moriz, Phan Jason, Rocchetti Francesca, Sankar Kyra, Sarkar Dhruba, Schaaf Otmar, Sensintaffar John L, Sun Qi, Wunberg Tobias, Fesik Stephen W
其它
发表日期：2025
文献求助 收藏

Academic-Industrial Collaboration in Synthesis with Real-Time Impact in Medicinal Chemistry: Discovery of Cystic Fibrosis C2 Corrector ABBV-602

产学研合作在药物化学合成领域实现实时影响：囊性纤维化C2矫正剂ABBV-602的发现

期刊:ACS Medicinal Chemistry Letters
影响因子:4
doi:10.1021/acsmedchemlett.5c00456
Voight, Eric A; Gong, Wei; Hardee, David J; Hodges, Timothy R; Schrimpf, Michael R; Lathrop, Stephen P; Sharland, Jack C; Wei, Bo; Davies, Huw M L
发表日期：2025
文献求助 收藏

σ(2)R/TMEM97 in retinal ganglion cell degeneration

σ(2)R/TMEM97 在视网膜神经节细胞退化中的作用

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-022-24537-3
Wang, Hua; Peng, Zhiyou; Li, Yiwen; Sahn, James J; Hodges, Timothy R; Chou, Tsung-Han; Liu, Qiong; Zhou, Xuezhi; Jiao, Shuliang; Porciatti, Vittorio; Liebl, Daniel J; Martin, Stephen F; Wen, Rong
细胞生物学
发表日期：2022
文献求助 收藏

Asymmetric synthesis of pharmaceutically relevant 1-aryl-2-heteroaryl- and 1,2-diheteroarylcyclopropane-1-carboxylates

具有药用价值的1-芳基-2-杂芳基-和1,2-二杂芳基环丙烷-1-羧酸酯的不对称合成

期刊:Chemical Science
影响因子:7.4
doi:10.1039/d1sc02474d
Sharland, Jack C; Wei, Bo; Hardee, David J; Hodges, Timothy R; Gong, Wei; Voight, Eric A; Davies, Huw M L
发表日期：2021
文献求助 收藏

Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS

苯并咪唑衍生物激活剂对 RAS 上 SOS1 介导的核苷酸交换的发现和基于结构的优化

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.8b01108
Hodges, Timothy R; Abbott, Jason R; Little, Andrew J; Sarkar, Dhruba; Salovich, James M; Howes, Jennifer E; Akan, Denis T; Sai, Jiqing; Arnold, Allison L; Browning, Carrie; Burns, Michael C; Sobolik, Tammy; Sun, Qi; Beesetty, Yugandhar; Coker, Jesse A; Scharn, Dirk; Stadtmueller, Heinz; Rossanese, Olivia W; Phan, Jason; Waterson, Alex G; McConnell, Darryl B; Fesik, Stephen W
RAS
发表日期：2018
文献求助 收藏