日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A novel mouse model of diffuse midline glioma initiated in neonatal oligodendrocyte progenitor cells highlights cell-of-origin dependent effects of H3K27M

新生儿少突胶质细胞祖细胞中起始的弥漫性中线胶质瘤新型小鼠模型突出了 H3K27M 的细胞来源依赖性作用

Yusuke Tomita, Yosuke Shimazu, Agila Somasundaram, Yoshihiro Tanaka, Nozomu Takata, Yukitomo Ishi, Samantha Gadd, Rintaro Hashizume, Angelo Angione, Gonzalo Pinero, Dolores Hambardzumyan, Daniel J Brat, Christine M Hoeman, Oren J Becher

A New IRF-1-Driven Apoptotic Pathway Triggered by IL-4/IL-13 Kills Neonatal Th1 Cells and Weakens Protection against Viral Infection

IL-4/IL-13触发的新型IRF-1驱动的细胞凋亡通路会杀死新生儿Th1细胞并削弱其对病毒感染的保护作用

Miller, Mindy M; Barik, Subhasis; Cattin-Roy, Alexis N; Ukah, Tobechukwu K; Hoeman, Christine M; Zaghouani, Habib

A high-throughput in vitro drug screen in a genetically engineered mouse model of diffuse intrinsic pontine glioma identifies BMS-754807 as a promising therapeutic agent

在弥漫性内在性脑桥神经胶质瘤基因工程小鼠模型中进行的高通量体外药物筛选表明 BMS-754807 是一种有前途的治疗药物

Kyle G Halvorson, Kelly L Barton, Kristin Schroeder, Katherine L Misuraca, Christine Hoeman, Alex Chung, Donna M Crabtree, Francisco J Cordero, Raj Singh, Ivan Spasojevic, Noah Berlow, Ranadip Pal, Oren J Becher

IL-13Rα1 is a surface marker for M2 macrophages influencing their differentiation and function

IL-13Rα1 是 M2 巨噬细胞的表面标志物,影响其分化和功能

Mermagya Dhakal, John C Hardaway, Fatma Betul Guloglu, Mindy M Miller, Christine M Hoeman, Adam A Zaghouani, Xiaoxiao Wan, Linda M Rowland, Jason A Cascio, Michael P Sherman, Habib Zaghouani

Recovery from overt type 1 diabetes ensues when immune tolerance and β-cell formation are coupled with regeneration of endothelial cells in the pancreatic islets

当免疫耐受和β细胞生成与胰岛内皮细胞再生同时发生时,1型糖尿病患者便可从明显的1型糖尿病中康复。

Wan, Xiaoxiao; Guloglu, F Betul; Vanmorlan, Amie M; Rowland, Linda M; Zaghouani, Sarah; Cascio, Jason A; Dhakal, Mermagya; Hoeman, Christine M; Zaghouani, Habib

Antigen-free adjuvant assists late effector CD4 T cells to transit to memory in lymphopenic hosts

无抗原佐剂可帮助淋巴细胞减少宿主中的晚期效应CD4 T细胞向记忆细胞转化

Guloglu, F Betul; Ellis, Jason S; Wan, Xiaoxiao; Dhakal, Mermagya; Hoeman, Christine M; Cascio, Jason A; Zaghouani, Habib

Developmental expression of IL-12Rβ2 on murine naive neonatal T cells counters the upregulation of IL-13Rα1 on primary Th1 cells and balances immunity in the newborn.

小鼠幼稚新生儿 T 细胞上 IL-12Rβ2 的发育表达可抵消原代 Th1 细胞上 IL-13Rα1 的上调,从而平衡新生儿的免疫力

Hoeman Christine M, Dhakal Mermagya, Zaghouani Adam A, Cascio Jason A, Wan Xiaoxiao, Khairallah Marie-Therese, Chen Weirong, Zaghouani Habib

Mechanisms underlying antigen-specific tolerance of stable and convertible Th17 cells during suppression of autoimmune diabetes

自身免疫性糖尿病抑制过程中稳定型和可转化型Th17细胞抗原特异性耐受的潜在机制

Wan, Xiaoxiao; Guloglu, F Betul; VanMorlan, Amie M; Rowland, Linda M; Jain, Renu; Haymaker, Cara L; Cascio, Jason A; Dhakal, Mermagya; Hoeman, Christine M; Tartar, Danielle M; Zaghouani, Habib

Bone marrow-derived IL-13Rα1-positive thymic progenitors are restricted to the myeloid lineage

骨髓来源的IL-13Rα1阳性胸腺祖细胞仅限于髓系。

Haymaker, Cara L; Guloglu, F Betul; Cascio, Jason A; Hardaway, John C; Dhakal, Mermagya; Wan, Xiaoxiao; Hoeman, Christine M; Zaghouani, Sarah; Rowland, Linda M; Tartar, Danielle M; VanMorlan, Amie M; Zaghouani, Habib

T cell dynamics during induction of tolerance and suppression of experimental allergic encephalomyelitis

诱导耐受和抑制实验性变应性脑脊髓炎过程中的T细胞动力学

Divekar, Rohit D; Haymaker, Cara L; Cascio, Jason A; Guloglu, Betul F; Ellis, Jason S; Tartar, Danielle M; Hoeman, Christine M; Franklin, Craig L; Zinselmeyer, Bernd H; Lynch, Jennifer N; Miller, Mark J; Zaghouani, Habib