日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The 4-alkyl chain length of 2,5-dimethoxyamphetamines differentially affects in vitro serotonin receptor actions versus in vivo psychedelic-like effects

2,5-二甲氧基苯丙胺的4-烷基链长度对其体外血清素受体活性和体内迷幻样效应的影响不同。

Luethi, Dino; Glatfelter, Grant C; Pottie, Eline; Sellitti, Francesca; Maitland, Alexander D; Gonzalez, Nicholas R; Kryszak, Lindsay A; Jackson, Shelley N; Hoener, Marius C; Stove, Christophe P; Liechti, Matthias E; Smieško, Martin; Baumann, Michael H; Simmler, Linda D; Rudin, Deborah

Preclinical development of [(18)F]TAAR1-2203 as a PET radioligand for imaging TAAR1 expression and receptor occupancy

[(18)F]TAAR1-2203 作为 PET 放射性配体用于 TAAR1 表达和受体占有率成像的临床前开发

Haider, Achi; Xiao, Zhiwei; Chen, Jiahui; Pfister, Stefanie K; Zhou, Xin; Li, Yinlong; Chaudhary, Ahmad; Zhao, Chunyu; Rong, Jian; Paehler, Axel; Mohr, Susanne; Norcross, Roger D; Honer, Michael; Mu, Linjing; Gobbi, Luca; Schibli, Roger; Hoener, Marius C; Liang, Steven H

Angelman syndrome patient-derived neuron screen leads to clinical ASO rugonersen targeting UBE3A-ATS with long-lasting effect in monkeys.

安格曼综合征患者来源的神经元筛选产生了临床 ASO rugonersen,该药物靶向 UBE3A-ATS,在猴子身上具有持久疗效

Jagasia Ravi, Bon Charlotte, Rasmussen Soren V, Badillo Solveig, Tehler Disa, Buchy Danièle, Berrera Marco, Prasad Megana, Chamberlain Stormy, Terrigno Marco, Pandya Nikhil J, Costa Veronica, Wang Congwei, Pedersen Lykke, Miller Meghan T, Erichsen Kamille Dumong, Joenson Lars, Patsch Christoph, Hipp Joerg F, Bonni Azad, Müller Lutz, Braendli-Baiocco Annamaria, Kremer Thomas, Koller Erich, Hoener Marius C

Receptor interaction profiles of 4-alkoxy-2,6-dimethoxyphenethylamines (Ψ derivatives) and related amphetamines

4-烷氧基-2,6-二甲氧基苯乙胺(Ψ衍生物)及相关苯丙胺的受体相互作用谱

Kolaczynska, Karolina E; Trachsel, Daniel; Hoener, Marius C; Liechti, Matthias E; Luethi, Dino

Wakefulness Induced by TAAR1 Partial Agonism in Mice Is Mediated Through Dopaminergic Neurotransmission

TAAR1部分激动剂诱导小鼠觉醒是通过多巴胺能神经传递介导的。

Park, Sunmee; Heu, Jasmine; Hoener, Marius C; Kilduff, Thomas S

Trace amine-associated receptors (TAARs)2-9 knockout mice exhibit reduced wakefulness and disrupted REM sleep.

微量胺相关受体 (TAARs)2-9 敲除小鼠表现出清醒时间减少和快速眼动睡眠紊乱

Park Sunmee, Heu Jasmine, Scheldrup Gavin, Tisdale Ryan K, Sun Yu, Haire Meghan, Ma Shun-Chieh, Hoener Marius C, Kilduff Thomas S

Effect of the TAAR1 Partial Agonist Ralmitaront on Presynaptic Dopamine Synthesis Capacity Measured Using [(18)F]DOPA PET in Naïve and Cocaine-Treated Mice

TAAR1部分激动剂雷米他隆对未接受过治疗和可卡因处理的小鼠突触前多巴胺合成能力的影响(采用[(18)F]DOPA PET测量)

Bonsall, David R; Kokkinou, Michelle; Halff, Els F; Rutigliano, Grazia; Tang, Sac-Pham; Veronese, Mattia; Irvine, Elaine E; Withers, Dominic J; Wells, Lisa A; Natesan, Sridhar; Gerlach, Irene; Holiga, Štefan; Hoener, Marius C; Howes, Oliver D

Wakefulness Induced by TAAR1 Partial Agonism is Mediated Through Dopaminergic Neurotransmission

TAAR1部分激动剂诱导的觉醒是通过多巴胺能神经传递介导的。

Park, Sunmee; Heu, Jasmine; Hoener, Marius C; Kilduff, Thomas S

Use of the head-twitch response to investigate the structure-activity relationships of 4-thio-substituted 2,5-dimethoxyphenylalkylamines

利用头部抽搐反应研究4-硫代取代的2,5-二甲氧基苯基烷基胺的构效关系

Halberstadt, Adam L; Luethi, Dino; Hoener, Marius C; Trachsel, Daniel; Brandt, Simon D; Liechti, Matthias E

Effects of acute and chronic administration of trace amine-associated receptor 1 (TAAR1) ligands on in vivo excitability of central monoamine-secreting neurons in rats

急性及慢性给予痕量胺相关受体1(TAAR1)配体对大鼠中枢单胺分泌神经元体内兴奋性的影响

Grinchii, Daniil; Hoener, Marius C; Khoury, Talah; Dekhtiarenko, Roman; Nejati Bervanlou, Reyhaneh; Jezova, Daniela; Dremencov, Eliyahu