日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Evaluating the Antiviral Efficacy of Encapsulated PKC Inhibitor BIM-I against influenza A Virus Infection

评估封装型 PKC 抑制剂 BIM-I 对甲型流感病毒感染的抗病毒功效

Klement, Laura; Ismail, Jana; Schroeder, Josefine; Godbole, Amod; Schreiber, Johanna; Weber, Christine; Cseresnyes, Zoltan; Figge, Marc T; Löffler, Bettina; Schubert, Ulrich S; Schubert, Stephanie; Ehrhardt, Christina; Hoffmann, Carsten

Cytoplasmic tail diversity determines the effector bias of the adhesion GPCR ADGRL2.

细胞质尾部的多样性决定了粘附 GPCR ADGRL2 的效应器偏好性。

Garbett Krassimira A, Zheng Chen, Drube Julia, Hoffmann Carsten, Gurevich Vsevolod V, Sando Richard C

Beef-Derived Peptides Mediated Desensitization of Bitter Taste Receptor T2R14 Through GPCR Kinase 2

牛肉来源肽通过GPCR激酶2介导苦味受体T2R14的脱敏

Singh, Nisha; Drube, Julia; Hoffmann, Carsten; Aluko, Rotimi Emmanuel; Chelikani, Prashen

GRK phosphorylation drives β-arrestin-independent internalization of chemokine receptor CXCR5

GRK磷酸化驱动趋化因子受体CXCR5的β-arrestin非依赖性内吞作用

Crecelius, Joseph M; Zhuo, Ya; Manz, Aaren R; Drube, Julia; Schulz, Stefan; Hoffmann, Carsten; Marchese, Adriano

Phosphorylation site topology governs the functional dynamics of arrestin recruitment to GPCRs

磷酸化位点拓扑结构决定了阻遏蛋白募集到GPCR的功能动态

Coin, Irene; Müller, Timo; Lee, Woojin; Alkara, Ammar; Baischew, Asat; Aydin, Yasmin; Lam, Jordy; Nagel, Falko; Hoffmann, Carsten; Schulz, Stefan; Sinz, Andrea; Katritch, Vsevolod

Novel atypical G protein-coupled receptor (GPCR)-arrestin complexes: a structural snapshot of the barcode hypothesis

新型非典型G蛋白偶联受体(GPCR)-arrestin复合物:条形码假说的结构快照

Filor, Jenny C; Matthees, Edda S F; Hoffmann, Carsten

Constitutive activity of an atypical chemokine receptor revealed by inverse agonistic nanobodies

反向激动性纳米抗体揭示非典型趋化因子受体的组成型活性

Perez Almeria, Claudia V; Otun, Omolade; Schlimgen, Roman; Lamme, Thomas D; Di Niro, Lotte; Crudden, Caitrin; Bebelman, Jan Paul; Youssef, Noureldine; Musli, Lejla; Jenjak, Shawn; Bobkov, Vladimir; Drube, Julia; Hoffmann, Carsten; Volkman, Brian F; Granier, Sébastien; Bechara, Cherine; Siderius, Marco; Heukers, Raimond; Schafer, Christopher T; Smit, Martine J

Multi-faceted roles of β-arrestins in G protein-coupled receptor endocytosis

β-arrestin在G蛋白偶联受体内吞作用中的多重作用

Liu, Junke; Xue, Li; Ravier, Magalie A; Eshak, Floriane; Acher, Francine C; Goupil-Lamy, Anne; Cimadevila, Marta; Drube, Julia; Hoffmann, Carsten; Inoue, Asuka; Trinquet, Eric; Dupuis, Elodie; Prézeau, Laurent; Pin, Jean-Philippe; Rondard, Philippe

Helix-bundle and C-terminal GPCR domains differentially influence GRK-specific functions and β-arrestin-mediated regulation.

螺旋束和 C 端 GPCR 结构域对 GRK 特异性功能和 β-arrestin 介导的调节具有不同的影响

Matthees Edda S F, Haider Raphael S, Klement Laura, Reichel Mona, Blum Nina K, Weitzel Verena, Trüpschuch Thimea, Ziegler Carla, Drube Julia, Schulz Stefan, Hoffmann Carsten

High-fat diet impairs microbial metabolite production and aggravates influenza A infection

高脂肪饮食会损害微生物代谢产物的产生,并加重甲型流感病毒感染。

Hornung, Franziska; SureshKumar, Harini K; Klement, Laura; Reisser, Yasmina; Wernike, Christoph; Nischang, Vivien; Jordan, Paul M; Werz, Oliver; Hoffmann, Carsten; Löffler, Bettina; Deinhardt-Emmer, Stefanie