日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Use of a cytochrome P450 humanized mouse model to refine schistosomiasis drug discovery

利用细胞色素P450人源化小鼠模型改进血吸虫病药物研发

Davey, Sarah D; Forde-Thomas, Josephine E; Hulme, Benjamin J; Lees, Kristin; Costain, Alice H; Evans, Mary; Rinaldi, Gabriel; Frame, Laura; Stojanovski, Laste; Simeons, Frederick R C; Tavendale, Amy; MacLeod, A Kenneth; Pichon, Remi; Lee, Yi-Hsuan; Polak, Oktawia; Chalmers, Iain W; Dankwa, Bismark; Odhiambo, Brenda Kisia; Guimaraes, Victor Hugo; Hegarty, Matthew; Swain, Martin T; Aubrey, Wayne; Caldwell, Nicola; MacDonald, Andrew S; Gilbert, Ian H; Baragaña, Beatriz; Read, Kevin D; Hoffmann, Karl F

Novel 1H-1,2,3-Triazole Derivatives of Praziquantel with TRPM(PZQ) Modulatory Activity and Antiparasitic Effects on Larvae, Juvenile, and Adult Worms of Schistosoma mansoni

新型吡喹酮1H-1,2,3-三唑衍生物及其对曼氏血吸虫幼虫、幼虫和成虫的TRPM(PZQ)调节活性和抗寄生虫作用

Junior, Floriano Paes Silva; Dantas, Rafael Ferreira; Park, Sang-Kyu; Whiteland, Helen; Oliveira, Camilla Thomaz da Silva; Rezende-Neto, João M; Reis, Jordano Ferreira; Forde-Thomas, Josephine; Gomes, Luciano Pinho; Valente, Walter C G; Schirato, Giuliana Viegas; Noronha, Frederico Ricardo de Castro Jr; Hoffmann, Karl F; Marchant, Jonathan S; Ferreira, Sabrina Baptista

Use of P450 Enzymes for Late-Stage Functionalization in Drug Discovery

P450酶在药物发现后期功能化中的应用

Poon, Vincent; Bailey, Christopher; Carvalho, Sandra; Patterson, Stephen; Fyfe, James W B; Semenova, Olga; Wrigley, Stephen K; Hopkins, Emily; Manohar, Ravi; Drake, Christopher; Kokubun, Tetsuo; Boyle, John; Kvaerno, Lisbet; Lees, Kristin; Hoffmann, Karl F; Forde-Thomas, Josephine; Wyllie, Susan; Steele, Jonathan; Gilbert, Ian H; Tarver, Gary J

Quinoxaline-based anti-schistosomal compounds have potent anti-plasmodial activity.

喹喔啉类抗血吸虫化合物具有很强的抗疟原虫活性

Rawat Mukul, Padalino Gilda, Adika Edem, Okombo John, Yeo Tomas, Brancale Andrea, Fidock David A, Hoffmann Karl F, Lee Marcus C S

Compounds Containing 2,3-Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin-Resistant Staphylococcus aureus, Enterococcus faecalis, and Their Biofilms

含有2,3-双(苯氨基)喹喔啉的化合物对耐甲氧西林金黄色葡萄球菌、粪肠球菌及其生物膜具有活性

Padalino, Gilda; Duggan, Katrina; Mur, Luis A J; Maillard, Jean-Yves; Brancale, Andrea; Hoffmann, Karl F

Special considerations for studies of extracellular vesicles from parasitic helminths: A community-led roadmap to increase rigour and reproducibility

寄生蠕虫细胞外囊泡研究的特殊考虑因素:一项由社区主导的提高研究严谨性和可重复性的路线图

White, Ruby; Sotillo, Javier; Ancarola, María Eugenia; Borup, Anne; Boysen, Anders Toftegaard; Brindley, Paul J; Buzás, Edit I; Cavallero, Serena; Chaiyadet, Sujittra; Chalmers, Iain W; Cucher, Marcela A; Dagenais, Maude; Davis, Chelsea N; Devaney, Eileen; Duque-Correa, Maria A; Eichenberger, Ramon Marc; Fontenla, Santiago; Gasan, Thomas A; Hokke, Cornelis H; Kosanovic, Maja; Kuipers, Marije E; Laha, Thewarach; Loukas, Alex; Maizels, Rick M; Marcilla, Antonio; Mazanec, Hynek; Morphew, Russell M; Neophytou, Kyriaki; Nguyen, Linh Thuy; Nolte-'t Hoen, Esther; Povelones, Michael; Robinson, Mark W; Rojas, Alicia; Schabussova, Irma; Smits, Hermelijn H; Sungpradit, Sivapong; Tritten, Lucienne; Whitehead, Bradley; Zakeri, Amin; Nejsum, Peter; Buck, Amy H; Hoffmann, Karl F

Modified Hederagenin Derivatives Demonstrate Ex Vivo Anthelmintic Activity against Fasciola hepatica

改性常春藤皂苷衍生物对肝片吸虫表现出体外驱虫活性

Chakroborty, Anand; Pritchard, Deiniol R; Bouillon, Marc E; Cervi, Anna; Kraehenbuehl, Rolf; Wild, Charlotte; Fenn, Caroline; Holdsworth, Peter; Capner, Colin; Padalino, Gilda; Forde-Thomas, Josephine E; Payne, Joseph; Smith, Brendan G; Fisher, Maggie; Lahmann, Martina; Baird, Mark S; Hoffmann, Karl F

Using ChEMBL to Complement Schistosome Drug Discovery

利用ChEMBL辅助血吸虫药物发现

Padalino, Gilda; Coghlan, Avril; Pagliuca, Giampaolo; Forde-Thomas, Josephine E; Berriman, Matthew; Hoffmann, Karl F

Perspective on Schistosomiasis Drug Discovery: Highlights from a Schistosomiasis Drug Discovery Workshop at Wellcome Collection, London, September 2022

血吸虫病药物研发展望:2022年9月在伦敦惠康收藏馆举办的血吸虫病药物研发研讨会亮点

Caldwell, Nicola; Afshar, Rana; Baragaña, Beatriz; Bustinduy, Amaya L; Caffrey, Conor R; Collins, James J; Fusco, Daniela; Garba, Amadou; Gardner, Mark; Gomes, Mireille; Hoffmann, Karl F; Hsieh, Michael; Lo, Nathan C; McNamara, Case W; Nono, Justin Komguep; Padalino, Gilda; Read, Kevin D; Roestenberg, Meta; Spangenberg, Thomas; Specht, Sabine; Gilbert, Ian H

Schistosoma mansoni Larval Extracellular Vesicle protein 1 (SmLEV1) is an immunogenic antigen found in EVs released from pre-acetabular glands of invading cercariae

曼氏血吸虫幼虫胞外囊泡蛋白1 (SmLEV1) 是一种免疫原性抗原,存在于入侵尾蚴的吸盘前腺释放的细胞外囊泡中。

Gasan, Thomas A; Kuipers, Marije E; Roberts, Grisial H; Padalino, Gilda; Forde-Thomas, Josephine E; Wilson, Shona; Wawrzyniak, Jakub; Tukahebwa, Edridah M; Hoffmann, Karl F; Chalmers, Iain W