日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targetable BIRC5 dependency in therapy-resistant TP53 mutated acute myeloid leukemia

治疗耐药性TP53突变急性髓系白血病中可靶向的BIRC5依赖性

Mamdouh, Ahmed M; Lim, Fang Qi; Mi, Yang; Olesinski, Elyse A; Chan, Cheryl Gek Teng; Jasdanwala, Shaista; Lin, Xiao Xian; Wang, Yichen; Tan, Jordan Yong Ming; Bhatia, Karanpreet Singh; Sapozhnikova, Valeriia; Wang, Chuqi; Mahesh, Aarthi Nivasini; Liang, Daniel Tan En; Chitkara, Nishtha; Mertins, Philipp; Hogdal, Leah; Brown, Brandon D; Haferlach, Torsten; Lobry, Camille; Lindsley, Coleman; Puissant, Alexandre; Ho, Han Kiat; Das, Sanjukta; Letai, Anthony; Kornblau, Steven M; Krönke, Jan; Ayoub, Edward; Itahana, Koji; Andreeff, Michael; Bhatt, Shruti

TP53 mutations drive therapy resistance via post-mitochondrial caspase blockade.

TP53 突变通过阻断线粒体后 caspase 导致治疗耐药性

Mamdouh Ahmed M, Olesinski Elyse A, Lim Fang Qi, Jasdanwala Shaista, Mi Yang, Lin Nicole Si En, Liang Daniel Tan En, Chitkara Nishtha, Hogdal Leah, Lindsley R Coleman, Letai Anthony, Itahana Koji, Bhatt Shruti

Pevonedistat and azacitidine upregulate NOXA (PMAIP1) to increase sensitivity to venetoclax in preclinical models of acute myeloid leukemia

Pevonedistat 和阿扎胞苷上调 NOXA (PMAIP1),从而增加急性髓系白血病临床前模型对维奈克拉的敏感性

Dan Cojocari, Brianna N Smith, Julie J Purkal, Maria P Arrate, Jason D Huska, Yu Xiao, Agnieszka Gorska, Leah J Hogdal, Haley E Ramsey, Erwin R Boghaert, Darren C Phillips, Michael R Savona

A Novel MCL1 Inhibitor Combined with Venetoclax Rescues Venetoclax-Resistant Acute Myelogenous Leukemia

一种新型MCL1抑制剂联合维奈托克可挽救维奈托克耐药的急性髓系白血病。

Haley E Ramsey ,Melissa A Fischer ,Taekyu Lee ,Agnieszka E Gorska ,Maria Pia Arrate ,Londa Fuller ,Kelli L Boyd ,Stephen A Strickland ,John Sensintaffar ,Leah J Hogdal ,Gregory D Ayers ,Edward T Olejniczak ,Stephen W Fesik ,Michael R Savona

Diminished apoptotic priming and ATM signalling confer a survival advantage onto aged haematopoietic stem cells in response to DNA damage

凋亡启动和 ATM 信号的减弱使衰老的造血干细胞在 DNA 损伤后具有生存优势

Paula Gutierrez-Martinez, Leah Hogdal, Manavi Nagai, Miriama Kruta, Rumani Singh, Kristopher Sarosiek, Andre Nussenzweig, Isabel Beerman, Anthony Letai, Derrick J Rossi

Blastic Plasmacytoid Dendritic Cell Neoplasm Is Dependent on BCL2 and Sensitive to Venetoclax

浆细胞样树突状细胞肿瘤依赖于 BCL2 且对维奈托克敏感

Joan Montero ,Jason Stephansky ,Tianyu Cai ,Gabriel K Griffin ,Lucia Cabal-Hierro ,Katsuhiro Togami ,Leah J Hogdal ,Ilene Galinsky ,Elizabeth A Morgan ,Jon C Aster ,Matthew S Davids ,Nicole R LeBoeuf ,Richard M Stone ,Marina Konopleva ,Naveen Pemmaraju ,Anthony Letai ,Andrew A Lane

Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways

通过抑制关键通路克服急性髓系白血病的突变复杂性

Yoriko Saito, Yoshiki Mochizuki, Ikuko Ogahara, Takashi Watanabe, Leah Hogdal, Shinsuke Takagi, Kaori Sato, Akiko Kaneko, Hiroshi Kajita, Naoyuki Uchida, Takehiro Fukami, Leonard D Shultz, Shuichi Taniguchi, Osamu Ohara, Anthony G Letai, Fumihiko Ishikawa

Discovery and biological characterization of potent myeloid cell leukemia-1 inhibitors

发现和生物学表征强效髓系细胞白血病-1抑制剂

Taekyu Lee ,Zhiguo Bian ,Bin Zhao ,Leah J Hogdal ,John L Sensintaffar ,Craig M Goodwin ,Johannes Belmar ,Subrata Shaw ,James C Tarr ,Nagarathanam Veerasamy ,Shannon M Matulis ,Brian Koss ,Melissa A Fischer ,Allison L Arnold ,DeMarco V Camper ,Carrie F Browning ,Olivia W Rossanese ,Amit Budhraja ,Joseph Opferman ,Lawrence H Boise ,Michael R Savona ,Anthony Letai ,Edward T Olejniczak ,Stephen W Fesik

Efficacy and Biological Correlates of Response in a Phase II Study of Venetoclax Monotherapy in Patients with Acute Myelogenous Leukemia

维奈克拉单药治疗急性髓性白血病患者的 II 期临床研究的疗效和生物学相关性

Marina Konopleva, Daniel A Pollyea, Jalaja Potluri, Brenda Chyla, Leah Hogdal, Todd Busman, Evelyn McKeegan, Ahmed Hamed Salem, Ming Zhu, Justin L Ricker, William Blum, Courtney D DiNardo, Tapan Kadia, Martin Dunbar, Rachel Kirby, Nancy Falotico, Joel Leverson, Rod Humerickhouse, Mack Mabry, Richard

Functionally identifiable apoptosis-insensitive subpopulations determine chemoresistance in acute myeloid leukemia

功能上可识别的凋亡不敏感亚群决定急性髓系白血病的化学耐药性

Patrick D Bhola, Brenton G Mar, R Coleman Lindsley, Jeremy A Ryan, Leah J Hogdal, Thanh Trang Vo, Daniel J DeAngelo, Ilene Galinsky, Benjamin L Ebert, Anthony Letai