Pharmacokinetic/pharmacodynamic modeling identifies SN30000 and SN29751 as tirapazamine analogues with improved tissue penetration and hypoxic cell killing in tumors
药代动力学/药效学模型确定 SN30000 和 SN29751 为替拉帕明类似物,具有更高的组织渗透性和对肿瘤缺氧细胞的杀伤作用。
期刊:Clinical Cancer Research
影响因子:10.2
doi:10.1158/1078-0432.CCR-10-1439
Hicks, Kevin O; Siim, Bronwyn G; Jaiswal, Jagdish K; Pruijn, Frederik B; Fraser, Annie M; Patel, Rita; Hogg, Alison; Liyanage, H D Sarath; Dorie, Mary Jo; Brown, J Martin; Denny, William A; Hay, Michael P; Wilson, William R