Stromal reprogramming overcomes resistance to RAS-MAPK inhibition to improve pancreas cancer responses to cytotoxic and immune therapy
基质重编程克服了对RAS-MAPK抑制剂的耐药性,从而改善了胰腺癌对细胞毒性药物和免疫疗法的反应。
期刊:Science Translational Medicine
影响因子:14.6
doi:10.1126/scitranslmed.ado2402
Liu, Xiuting; Baer, John M; Stone, Meredith L; Knolhoff, Brett L; Hogg, Graham D; Turner, Madeleine C; Kao, Yu-Lan; Weinstein, Alyssa G; Ahmad, Faiz; Chen, Jie; Schmidt, Andrew D; Klomp, Jeffrey A; Coho, Heather; Coho, Kayjana S; Coma, Silvia; Pachter, Jonathan A; Bryant, Kirsten L; Kang, Liang-I; Lim, Kian-Huat; Beatty, Gregory L; DeNardo, David G
肿瘤
肿瘤免疫
细胞生物学
MAPK/ERK
胰腺癌
RAS
毒理研究
免疫/内分泌